Clinical and Bacteriological Efficacy of Amoxycillin/Clavulanate (Spektramox) and Cefaclor (Kefolor) in Children with Recurrent aom or Therapy Failure

Jacobsson, S.; Rignér, P; Sydow, C. von; Bondesson, G

doi:10.3109/00016488809106370

Cited by 5 publications

(2 citation statements)

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“…59 The usual dosage for otitis media is 40 mg/kg/day, based on the amoxicillin component. This should be divided into three doses with a maximum single dose of 250 mg 62 and administered for a general course of 10 days. 59 The clavulanate content is not proportional to amoxicillin in the regular tablet preparation only, and amoxicillin-clavulanate is significantly more expensive than amoxicillin.…”

Section: Amoxicillin-clavulanatementioning

confidence: 99%

Pharmacotherapy of Otitis Media

Thoene,

Johnson

1991

Pharmacotherapy

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The clinical manifestations of acute otitis media and otitis media with effusion are the result of abnormal eustachian tube function most often caused by inflammation from infection or allergy. The majority of cases involve bacterial infection of the middle ear caused by Streptococcus pneumoniae, Haemophilus influenzae, or Branhamella catarrhalis. Nearly half of all children will have had at least one episode of acute otitis media by 1 year of age, and over 70% by 3 years of age. The signs and symptoms include pain with rubbing or tugging at the ear, fever, irritability, lethargy, and hearing loss. The primary therapy for acute otitis media and otitis media with effusion is antibiotics with the goal of preventing possible complications and providing symptomatic relief. Amoxicillin remains the initial drug of choice in communities where β‐lactamase‐producing strains of the common middle ear pathogens are infrequently isolated. If resistant organisms are prevalent, cefaclor, amoxicillin‐clavulanate, or cotrimoxazole should be selected. Adjuvant agents such as decongestants have not been shown to provide additional therapeutic benefit. Children who develop chronic otitis media may require prophylactic antibiotic therapy and insertion of typanostomy tubes.

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Section: Amoxicillin-clavulanatementioning

confidence: 99%

Pharmacotherapy of Otitis Media

Thoene,

Johnson

1991

Pharmacotherapy

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“…La eccellente palatabilità delle formulazioni orali di cefaclor ne facilita l'assunzione da parte dei bambini, elevando il livello di compliance [39]. Diverse ricerche cliniche e recenti metaanalisi hanno documentato che l'uso di cefaclor nelle OMA in età pediatrica è associato ad un tasso di guarigione clinica di circa il 90% e ad un tasso di guarigione microbiologica superiore all'80% [59][60][61][62][63][64][65][66].…”

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Pharmacoeconomic evaluation of cefaclor in the pharyngo-tonsillitis and acute otitis in children

Eandi

Giudice²

2006

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Pharyngotonsillitis (FT) and acute otitis media (OMA) are among the most frequent infectious diseases of the childhood and exact a heavy toll on the Italian national health service (INHS), families and society as a whole. In case of established or suspected bacterial origin, current treatment guidelines for FT recommend 5-10 days of oral antibiotics, chosen among available penicillins, cephalosporins, or macrolides. More controversial appears the systematical use of an antibiotic for OMAs, but prevalent expert opinion suggests use of the same agents. In this paper, an economical appraisal of five of the most prescribed oral antibiotics for these indications in Italy (cefaclor, amoxicyllin, amoxicyllin/clavulanate, clarithromycin and azithromycin) is provided. The evaluation was conducted through the development and implementation of two distinct models, constructed to reflect national treatment patterns of these infections. Clinical and economical data were obtained from several sources: literature review, including published meta-analyses, consultation of an expert panel and, most importantly, from the results of a specific questionnaire-based survey completed by 136 pediatricians, based throughout Italy. The models were run to conduct both cost-effectiveness and cost-minimization analyses, that consistently indicated cefaclor and amoxicyllin to be substantially equivalent in terms of total costs to the INHS and the Italian society, but significantly more convenient than amoxicyllin/clavulanate, claritrhomycin or azithromycin. Extensive probabilistic sensitivity analyses confirmed the robustness of this conclusion.

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Comparison of study designs for acute otitis media trials

Pichichero

Casey

2008

International Journal of Pediatric Otorhinolaryngology

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Clinical and Bacteriological Efficacy of Amoxycillin/Clavulanate (Spektramox) and Cefaclor (Kefolor) in Children with Recurrent aom or Therapy Failure

Cited by 5 publications

References 0 publications

Pharmacotherapy of Otitis Media

Pharmacotherapy of Otitis Media

Pharmacoeconomic evaluation of cefaclor in the pharyngo-tonsillitis and acute otitis in children

Comparison of study designs for acute otitis media trials

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