Clinical and angiographic profile of very young adults presenting with first acute myocardial infarction: Data from a tertiary care center in Central India

Deshmukh, Pradeep; Singh, Mohit; Deshpande, Mukund; Rajput, Atulsingh

doi:10.1016/j.ihj.2019.12.004

Cited by 27 publications

(36 citation statements)

References 12 publications

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“…[ 20 ] Hence, young adults with dyslipidaemia are more prone to develop CVDs. [ 21 ] A higher incidence rate (87.1%) of patients with one or multiple comorbidities in the present study suggest the high prevalence of diabetes and/or hypertension among patients with dyslipidaemia. Altogether these comorbidities may contribute to the increased risk of atherosclerotic CVDs.…”

Section: Discussionmentioning

confidence: 53%

Risk factors, comorbiditiEs and Atherogenic dysLipidaemia in Indian YOUNG patients with dyslipidaemia attending hospital/clinic: REAL YOUNG (dyslipidaemia) study

Iyengar

Narasingan

Gandhi³

et al. 2020

J Family Med Prim Care

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Objective: To evaluate the pattern of dyslipidaemia, risk factors, and comorbidities in young Indian adults with dyslipidaemia. Methods: A retrospective, multi-centric real-world study included individuals with dyslipidaemia, aged 18 - 45 years, attending to 623 hospitals/clinics across India. Data were collected retrospectively from medical records to note demographics, risk factors (smoking, alcohol consumption, sedentary lifestyle, family history of dyslipidaemia, diabetes mellitus, and hypertension), and clinical details (height, weight, waist circumference, body mass index (BMI), blood pressure, blood sugar, glycated hemoglobin (HbA1c), triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL-C), and high-density lipoprotein (HDL-C)).A descriptive analysis and comparative analysis (Mann-Whitney U test and Chi-square test) were done. Results: Of the total 8135 patients, the majority were men (65.0%). Overall, 87.1% of population had one or multiple comorbidities which included the presence of dyslipidaemia alone (12.9%), dyslipidaemia with diabetes and hypertension (39.1%), dyslipidaemia with diabetes (33.6%), and dyslipidaemia with hypertension (14.4%). Sedentary lifestyle was prevalent observation in >50% of the population. Youngest age (18 - 25) group had higher prevalence of hypertriglyceridemia (63.2%), high LDL-C levels (56.8%), and low HDL-C levels (64.6%), while patients from the age group >25 to ≤35 years had the highest incidence of hypercholesterolemia (66.6%). Atherogenic dyslipidaemia was observed in 41.9%, 25.5%, and 23.2% of patients from age groups of ≥18 to ≤25, >25 to ≤35, and >35 to ≤45 years, respectively. Patients with HbA1c ≥6.5% had significantly higher levels of TG, TC, LDL-C, and lower HDL-C compared to those with HbA1c <6.5%. Conclusion: Hypertriglyceridemia, high LDL-C, low HDL-C, and atherogenic dyslipidaemia were prevalent in the young Indian cohort and sedentary lifestyle, and HbA1c ≥ 6.5% were the predominant risk factors of dyslipidaemia.

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Section: Discussionmentioning

confidence: 53%

Risk factors, comorbiditiEs and Atherogenic dysLipidaemia in Indian YOUNG patients with dyslipidaemia attending hospital/clinic: REAL YOUNG (dyslipidaemia) study

Iyengar

Narasingan

Gandhi³

et al. 2020

J Family Med Prim Care

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“…Another cross-sectional study evaluated 41 STEMI patients and revealed that anterior wall MI was found in 82.9%, with obstructive CAD in 61% of patients due to involvement of LAD in 46.4% ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Cannabis and Tramadol addiction, do they imply paramount hazardous factors for acute myocardial infarction in young adults below 45 years old?

et al. 2020

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Objective: Acute myocardial infarction (AMI) is the main cause of cardiovascular events worldwide. AMI commonly occurs in elderly patients because of atherosclerotic process related to common risk factors. Consequently, the rupture of atheromatous plaque with deleterious sequela is the common etiology of the disease. However, there are less studied etiological factors in youth compared with the usual population. Therefore, this study aimed to examine the risk profile of Egyptian youth presenting with AMI. Methods: A study was conducted in 106 patients aged ≤45 years admitted with AMI in our university hospital to explore their clinical profile risk factors. Results: In the study, 71 (67%) and 35 (33%) patients presented with ST elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI). Anterior wall MI was predominant in 49 patients (46.2%). Moreover, 93 patients (88%) were smokers, 31 (29.2%) used tramadol, 43 (40.6%) smoked cannabis, 50 (47.2%) had poor sleeping habits, 29 (27.4%) had high stress levels, 37 (34.9%) had hypertension, and 22 (20.8%) had diabetes. Twenty (18.9%) patients had a family history of premature coronary artery disease. High and low high-density lipoprotein (HDL) levels were observed in 20 (18.9%) and 47 (44.3%) patients, respectively. The left anterior descending artery (LAD) was involved in 56% of the studied population associated with tramadol use. A significant association was found between both tramadol use and cannabis smoking and presence of heavy thrombus burden on coronary angiography. Conclusion: AMI in Egyptian youth was predominantly observed in men, with anterior STEMI as the most common presentation. Cannabis and tramadol addiction were high risk factors for AMI in Egyptian youth.

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“…Dyslipidemia was defined as serum total cholesterol (TC) ≥200 mg/dL, triglyceride (TG) >150 mg/dL, low-density lipoprotein (LDL) > 130 mg/dL, high-density lipoprotein (HDL) <50 mg/dL in women and <40 mg/dL in men, and/or those being treated with lipid-lowering therapy. 12 As thrombus load was concerned, if the largest diameter of thrombosis was twice larger than the vessel’s one, it was defined as large thrombosis, otherwise small thrombosis. 13 , 14 Reinfarction was defined as recurrence of ≥0.1 mV ST-segment elevation in at least two contiguous leads, or newly development of pathological Q waves in ECG; and rise of cardiac troponin (cTn) values with at least one value ≥20% of previous one, and the presence of symptoms suggestive of ischemia lasting 20 minutes or more.…”

Section: Methodsmentioning

confidence: 99%

“… 9 Stroke was defined as a focal neurological deficit lasting more than 24 hours due to an ischemic or hemorrhagic event, or a neurological event causing death. 12 Major bleeding was defined as intracranial hemorrhage, cardiac tamponade, hemoglobin value falling more than 5 g/dL even if the bleeding focus could not be determined, and bleeding-related death. Any bleeding was defined by the TIMI criterion.…”

Section: Methodsmentioning

confidence: 99%

Gender differences in clinical characteristics and in-hospital and one-year outcomes of young patients with ST-segment elevation myocardial infarction under the age of 40

Başaran

Kivanc

Dizman

et al. 2021

J Cardiovasc Thorac Res

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Introduction: Although the incidence of acute ST-segment elevation myocardial infarction (STEMI) in the elderly population has decreased in recent years, this is not the case for young people. At the same time, no reduction in hospitalization rate after STEMI was shown in young people. Clinical characteristics, risk factors, angiographic findings, in-hospital and one-year outcomes of patients under the age of 40 and their gender differences were investigated. Methods: This study has been performed retrospectively in two centers. Between January 2015 and April 2019, 212 patients aged 18-40 years with STEMI and who underwent reperfusion therapy were included. The gender differences were compared. Results: The median age of (male 176; 83.0% and female 36; 17.0%) patients included in the study was 36 (33-38) for men and 36 (34-38) for women. Chest pain was the most common complaint for both genders (96.0% vs. 94.4%; P = 0.651). While men presented more often with Killip class 1,women presented more often with Killip class 2. The anterior myocardial infarction (MI) was the most common MI type and it was higher in women than in man (P = 0.027). At one year of follow-up, the prevalence of all-cause hospitalization was 24%, MI 3.8%, coronary angiography 15.1%, cardiovascular death 1.4%, and all-cause death 0.47%, there was no gender difference. Conclusion: Anterior MI was the most common type of MI and it was more common in women than in men. Left anterior descending artery was the most common involved coronary artery. The most common risk factor is smoking. In terms of in-hospital outcome, left ventricular ejection fraction was significantly lower in women. There was no significant difference in one-year outcomes between both genders.

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Clinical and angiographic profile of very young adults presenting with first acute myocardial infarction: Data from a tertiary care center in Central India

Cited by 27 publications

References 12 publications

Risk factors, comorbiditiEs and Atherogenic dysLipidaemia in Indian YOUNG patients with dyslipidaemia attending hospital/clinic: REAL YOUNG (dyslipidaemia) study

Risk factors, comorbiditiEs and Atherogenic dysLipidaemia in Indian YOUNG patients with dyslipidaemia attending hospital/clinic: REAL YOUNG (dyslipidaemia) study

Cannabis and Tramadol addiction, do they imply paramount hazardous factors for acute myocardial infarction in young adults below 45 years old?

Gender differences in clinical characteristics and in-hospital and one-year outcomes of young patients with ST-segment elevation myocardial infarction under the age of 40

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