Clinical and anamnestic features of bronchial asthma in children from an ecologically unfavorable region

Chumachenko, N. G.

doi:10.15574/pp.2016.67.98

Cited by 3 publications

(4 citation statements)

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“…Визначення сезонності проявів БА є важливим, оскільки це передбачає корекцію профілактичного лікування у несприятливий період для зменшення клінічної симптоматики. Проте аналіз літератури виявив, що серед науковців немає чіткої одностайності, щодо періодів загострення БА [14,15].…”

Section: таблиця 1 клінічні прояви бронхіальної астми у дітей різного вікуunclassified

Features of Clinical Symptoms and the Influence of Risk Factors on the Occurrence of Bronchial Asthma in Children of Lviv Region of Different Ages

Трутяк

Lychkovska

Holovyn

et al. 2021

Scientific and practical journal

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Bronchial asthma (BA) is a common chronic pathology of the lower respiratory tract in children. The first manifestations of the disease can begin at any age, but the clinical features, of the course, are different in different periods of childhood. Manifestations and course of asthma may disappear or progress with age. Therefore, it is likely that there are differences in the pathophysiology, inflammatory response of the body and the features of the clinic of asthma in children of different ages, which affects the diagnosis and treatment. The aim of the study was to determine the features of clinical symptoms and the influence of risk factors for asthma on its occurrence in children of different ages. Materials and methods. We analyzed the anamnesis and clinical symptoms of 57 children aged 3 to 18 years, who were treated from September 2020 to June 2021 in the Lviv Regional Children's Clinical Hospital “OHMATDYT” and in the Lviv Municipal City Children's Clinical Hospital. The age groups did not differ statistically in the severity of asthma (P> 0.05). Thus, in group 1 was 1 patient (9.09%) with mild form, 1 patient (9.09%) - moderate persistent form, 8 patients (72.73%) - with severe persistent form. Among patients of age group 2 was 1 patient (3.85%) with mild persistent form, 3 children (11.54%) - moderate and 21 children (80.77%) - with severe persistent form. In group 3 was 1 patient (5%) with a mild persistent form, 6 patients (30%) - moderate and 12 children (80%) - with a severe persistent form. The vast majority of patients were boys (84.21 ± 4.83%). All patients underwent general clinical examinations, spirometry, and allergy tests. We used the clinical-anamnestic method to perform the tasks of the work, which consisted in collecting a detailed somatic and genealogical anamnesis during the parents` questionnaire. Physical development of children was assessed using centile tables. Statistics were evaluated by calculating Student's t-test and Pearson's consistency test. Preschool children with asthma were more likely to experience shortness of breath during exercise and a wet low-yielding cough, and children of primary and secondary school age were more characterized by concomitant allergic rhinitis. Autumn was more unfavorable period for the exacerbation of clinical manifestations of asthma in children of Lviv region was period. We did not find correlation of birth weight on the timing of asthma. However, a burdensome obstetric history contributed to the early development of clinical manifestations of asthma. Preschool children were more likely to be exposed to nicotine during the antenatal period and had a shorter duration of breastfeeding, which may be a probable risk factor for asthma in preschool children. In 77% of children from different age groups were burdened with a history of allergies, with 66% of cases more pronounced in the maternal line. An analysis of physical development revealed that most preschool children were overweight. Conclusions. Asthma has features of clinical symptoms in children of different ages - shortness of breath during exercise and whooping cough are characteristic of preschool children, and concomitant chronic persistent rhinitis - for older age groups. Seasonal exacerbations are characteristic of asthma in children; in particular, the autumn period is more unfavorable, common for asthmatics in children of all ages among patients in Lviv region. Maternal smoking during pregnancy has a significant effect on the risk of developing asthma in children. Also, a burdened maternal allergy history and overweight child contributes to the development of asthma in children.

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Section: таблиця 1 клінічні прояви бронхіальної астми у дітей різного вікуunclassified

Features of Clinical Symptoms and the Influence of Risk Factors on the Occurrence of Bronchial Asthma in Children of Lviv Region of Different Ages

Трутяк

Lychkovska

Holovyn

et al. 2021

Scientific and practical journal

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“…In addition, diseases of the respiratory system that develop in childhood, further lead to disability of patients in adulthood. Among chronic lung diseases in children, the leading positions are occupied by bronchial asthma (40 %) and recurrent bronchitis (40 %) [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Such enzymes are released during the immune response when the lungs are exposed to long-term pathogens. Although these proteolytic enzymes are key to killing pathogens if left unchecked, they can destroy the lung tissue [1].…”

Section: Introductionmentioning

confidence: 99%

Genetic testing of allelic variants of PIZ (GLU342Lys, RS28929474) and PIS (GLU264Val, RS17580) of SERPINA1 gene in children with bronchial asthma

et al. 2022

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According to world publications, mutations in the SERPINA1 gene may be a genetic risk factor for severe chronic obstructive pulmonary disease and, consequently, rapid progression of respiratory dysfunction. This disease leads to a decrease in the level of alpha-1-antitrypsin protein. It is inherited by autosomal recessive type, but there are registered cases of codominance. In the absence of treatment, diseases of the respiratory system become chronic and lead to disability in adulthood. Early diagnosis of AAT deficiency is important to prevent complications and reduce mortality among people with this pathology. Due to these factors, genetic testing of SERPINA1 gene mutations in children with chronic lung diseases is appropriate to detect and prevent severe complications, associated with AATD. The aim of this work is to improve the effectiveness of early diagnosis of AAT deficiency in children with bronchial asthma and recurrent obstructive bronchitis by identifying different genotypes and phenotypes of A1AT deficiency, studying their relationship with the clinical course of respiratory diseases in children

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“…In Ukraine, the number of patients with BA ranges from 2 to 15% among child population and is also growing steadily. Thus, according to official statistics data of the Ministry of Healthcare of Ukraine, 37,422 (0.49%) patients with BA were registered among the child population in 2015 [2]. Today, bronchial asthma is defined as a heterogeneous disease with the development of the most typical clinical sign that is an attack of expiratory suffocation.…”

Section: Introductionmentioning

confidence: 99%

New aspect of studying the mechanisms of development of the lungs ventilation capacity disorders in children with bronchial asthma

Shumna

Fedosieieva

Kamyshnyi

2020

J Educ Health Sport

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Purpose. Study of the pathogenetic role of the polymorphism of the ACTN3 gene (actinin, alpha 3) rs1815739 in the development of lungs ventilation capacity disorders in children with bronchial asthma. 157 pronounced in asthma attacks, which can lead to less pronounced disorders of lungs ventilation capacity. Conclusions. The study of ACTN3 (actinin, alpha 3) rs1815739 gene polymorphism showed that the C / C and C / T genotypes were associated with impaired lung ventilation in children with bronchial asthma.

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Clinical and anamnestic features of bronchial asthma in children from an ecologically unfavorable region

Cited by 3 publications

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Features of Clinical Symptoms and the Influence of Risk Factors on the Occurrence of Bronchial Asthma in Children of Lviv Region of Different Ages

Features of Clinical Symptoms and the Influence of Risk Factors on the Occurrence of Bronchial Asthma in Children of Lviv Region of Different Ages

Genetic testing of allelic variants of PIZ (GLU342Lys, RS28929474) and PIS (GLU264Val, RS17580) of SERPINA1 gene in children with bronchial asthma

New aspect of studying the mechanisms of development of the lungs ventilation capacity disorders in children with bronchial asthma

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