The article is devoted to problems of creation of comfortable microclimate. Identifi es sources of pollution, completed their evaluation. Special att ention is paid to the selection of environmentally friendly building materials. In the production of building materials where toxic components can be industrial waste, replacing natural raw materials and chemical additives regulating the properties. In the operation of many building materials, especially those based on polymers, it is necessary to control the release of toxic substances resulting from degradation. For the assessment of comfort and environmental safety of housing is offered to create «Passports of residential buildings», which should be provided with information about construction materials used to evaluate this parameter, environmental home safety, including chemical safety as its component.
To study the association of polymorphisms of the enzymes genes CYP1A1 (T6235C), first phase, and NAT2 (Ñ481Ò, G590A, G857A), GSTM1 («0»), GSTT1 («0») and GSTP1 (A313G), second phase of the detoxication system, as well as the ADRB2 (C79G) gene variants with the development of bronchial asthma in children. Methods. Polymorphic variants were analyzed using PCR followed by RFLP analysis in 86 healthy individuals and in 114 patients with clinical diagnosis of bronchial asthma. Results. The frequency of gene polymorphic variants of the enzymes of first and second phases of detoxification system as well as the ADRB2 gene was established in the children with bronchial asthma and healthy individuals. Conclusions. Ðolymorphic variants of the genes NAT2 (481Ò), GSTP1 (313G) and ADRB2 (79G) and their combinations in genotype were observed more frequently in the patients with bronchial asthma comparing to the control group, which indicates their involvement in the pathogenesis of asthma in children
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