Clinical Analysis of Preoperative Anti-thyroglobulin Antibody in Papillary Thyroid Cancer Between 2011 and 2015 in Beijing, China: A Retrospective Study

Abstract

The anti-thyroglobulin antibody (TgAb) has been suggested to be more common in patients with papillary thyroid cancer (PTC). Here, we performed a retrospective study investigated the correlation between TgAb level and PTC in Chinese patients between 2011 and 2015. Patients with goiter who underwent thyroidectomy and received a confirmed pathological diagnosis were enrolled into the study. Clinical characteristics and preoperative thyroglobulin antibody (TgAb) level data were collected from all enrolled patients. Based on the preoperative TgAb test results, patients were divided into a TgAb negative (TgAb-) group (<60 IU/mL) and a TgAb positive (TgAb+) group (≧60 IU/mL). Of the 4,046 patients, 671 patients were TgAb+ while 3,375 patients were TgAb-. There were 535 (79.7%) patients with PTC in the TgAb+ group, and 2,154 (63.8%) patients with PTC in the TgAb-group. The prevalance of PTC was significantly higher in TgAb+ patients than in TgAb-patients. TgAb+ patients were stratified into four groups based on the TgAb titer. The prevalence of PTC did not increase with TgAb titer. No significant difference in TgAb level was noted in patients with different clinicopathologies, including TNM stage, lymph node metastasis, and multifocal carcinoma. Regression analysis suggested a higher risk of PTC malignancy among TgAb+ patients. Preoperative TgAb level ≥60 IU/mL might be associated with a higher risk of PTC. However, there was no titer-dependent association between elevated TgAb titer and PTC malignancy.

Longitudinal Change of Postoperative Serum Anti-thyroglobulin Antibody Levels in Patients Without Total Thyroidectomy and Remnant Ablation

“…There were 535 (79.7%) patients with PTC in the TgAb-positive group and 2,154 (63.8%) with PTC in the TgAbnegative group. The prevalence of PTC was signi cantly higher in TgAb-positive patients than in TgAbnegative patients (13). Our result of consistently positive TgAb values of 21.6% and consistently negative TgAb values of 68% was similar to other reports.…”

Relationship Between Thyroid Autoantibodies and Recurrence of Papillary Thyroid Carcinoma in Children and Adolescents

“…Our study showed that thyroid autoantibodies were associated with better clinicopathologic features in children and adolescents with PTC. The possible potential mechanism was that TgAb could specifically recognize epitopes on the Tg of PTC patients to cause tumor epitope-specific immune responses, increase the destruction of cancer cells and exert its protective effect by regulating the tumor microenvironment ( 26 , 27 ). TPOAb may mediate by complement-mediated cell death and/or antibody-dependent cytotoxicity to exert its anti-cancer effect ( 28 ).…”

The prevalence and associated predictors for Bethesda III–VI for reporting thyroid cytopathology in Royal Commission Hospital, Kingdom of Saudi Arabia

“… 9 , 13 – 15 Thyroid FNAC management was cost-effective compared with watchful management. 16 Several factors – such as age, 17 female sex, 18 thyroid status, thyroid hormone level, 19 thyroid autoantibodies, 20 metabolic syndrome components, 21 , 22 smoking and alcohol consumption, 23 environmental factors, 18 , 24 diet and nutritional pattern, 25 and genetic factors 26 – have been reported as risk factors associated with thyroid nodular diseases and cancers.…”