Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia

Zhu, Huaping; Wang, Lin; Fang, Chengzhi; Peng, Sicong; Zhang, Lianhong; Gui-ping, Chang; Xia, Shiwen; Zhou, Wenhao

doi:10.21037/tp.2020.02.06

Cited by 1,221 publications

(1,753 citation statements)

References 11 publications

Supporting

Mentioning

1,454

Contrasting

Unclassified

155

Order By: Relevance

“…13 In our study, 44% and 36% pregnant women presented initial onset of fever in either laboratory-confirmed or clinicallydiagnosed group, which was less common than 87.9% in the nonpregnant population in the study by Guan et al 11 and consistent with the previous study enrolling 9 pregnant women with COVID-19. 17 Currently, fever served as the basic screening flag in China. Absence of typical symptoms increased the difficulty of the surveillance in the pregnant population.…”

Section: Discussionmentioning

confidence: 99%

Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children

Liu¹,

Liu²,

Li³

et al. 2020

Journal of Infection

371

213

View full text Add to dashboard Cite

s u m m a r yBackground: The ongoing outbreak of COVID-19 pneumonia is globally concerning. We aimed to investigate the clinical and CT features in the pregnant women and children with this disease, which have not been well reported. Methods: Clinical and CT data of 59 patients with COVID-19 from January 27 to February 14, 2020 were retrospectively reviewed, including 14 laboratory-confirmed non-pregnant adults, 16 laboratory-confirmed and 25 clinically-diagnosed pregnant women, and 4 laboratory-confirmed children. The clinical and CT features were analyzed and compared. Findings: Compared with the non-pregnant adults group ( n = 14), initial normal body temperature (9 [56%] and 16 [64%]), leukocytosis (8 [50%] and 9 [36%]) and elevated neutrophil ratio (14 [88%] and 20 [80%]), and lymphopenia (9 [56%] and 16 [64%]) were more common in the laboratory-confirmed ( n = 16) and clinically-diagnosed ( n = 25) pregnant groups. Totally 614 lesions were detected with predominantly peripheral and bilateral distributions in 54 (98%) and 37 (67%) patients, respectively. Pure ground-glass opacity (GGO) was the predominant presence in 94/131 (72%) lesions for the non-pregnant adults. Mixed consolidation and complete consolidation were more common in the laboratory-confirmed (70/161 [43%]) and clinically-diagnosed (153/322 [48%]) pregnant groups than 37/131 (28%) in the non-pregnant adults ( P = 0 ·007, P < 0 ·001). GGO with reticulation was less common in 9/161 (6%) and 16/322 (5%) lesions for the two pregnant groups than 24/131 (18%) for the non-pregnant adults ( P = 0 ·001, P < 0 ·001). The pulmonary involvement in children with COVID-19 was mild with a focal GGO or consolidation. Twentythree patients underwent follow-up CT, revealing progression in 9/13 (69%) at 3 days whereas improvement in 8/10 (80%) at 6-9 days after initial CT scans. Interpretation: Atypical clinical findings of pregnant women with COVID-19 could increase the difficulty in initial identification. Consolidation was more common in the pregnant groups. The clinically-diagnosed cases were vulnerable to more pulmonary involvement. CT was the modality of choice for early detection, severity assessment, and timely therapeutic effects evaluation for the cases with epidemic and clinical features of COVID-19 with or without laboratory confirmation. The exposure history and clinical symptoms were more helpful for screening in children versus chest CT.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children

Liu¹,

Liu²,

Li³

et al. 2020

Journal of Infection

371

213

View full text Add to dashboard Cite

show abstract

“…A total of eighteen pregnant women infected with NCP (mean age: 30 years) had one or two common clinical symptoms, such as fever, cough, cholecystitis, sore throat, and diarrhea. The birth weight (BW) of the newborns from these mothers ranged 1,520 g to 3,820 g, and the twin babies had the lowest BW (Zhu et al, 2020;Chen et al, 2020). One-minute Apgar scores ranged 7-10, and 5-min Apgar scores J o u r n a l P r e -p r o o f ranged 8-10 (Zhu et al, 2020;Chen et al, 2020).…”

Section: Clinical Outcomes Of Pregnant Women With Covid-19mentioning

confidence: 98%

“…The birth weight (BW) of the newborns from these mothers ranged 1,520 g to 3,820 g, and the twin babies had the lowest BW (Zhu et al, 2020;Chen et al, 2020). One-minute Apgar scores ranged 7-10, and 5-min Apgar scores J o u r n a l P r e -p r o o f ranged 8-10 (Zhu et al, 2020;Chen et al, 2020). The onset of clinical symptoms to delivery took 1 to 7 days (Chen et al, 2020).…”

Section: Clinical Outcomes Of Pregnant Women With Covid-19mentioning

confidence: 99%

“…However, the impact of COVID-19 on pregnant women has not been studied well and drawn much attention (Favre et al, 2020;Qiao J, 2020) regarding maternal morbidity, mortality, and perinatal outcomes. The currently published two papers analyzed the clinical characteristics of the mothers (total 18 cases) with novel coronavirus pneumonia (NCP) in the third trimester (from 31 to 40 weeks gestation) and their babies (Zhu et al, 2020;Chen et al, 2020). A total of eighteen pregnant women infected with NCP (mean age: 30 years) had one or two common clinical symptoms, such as fever, cough, cholecystitis, sore throat, and diarrhea.…”

Section: Clinical Outcomes Of Pregnant Women With Covid-19mentioning

confidence: 99%

“…Later on, thrombocytopenia with abnormal liver function, gastrointestinal hemorrhage, and refractory shock were manifested. Notably, one of the infected neonates died with an increased heart rate, refractory shock, gastric bleeding, multiple organ failure, and disseminated intravascular coagulation, whose mother underwent vaginal bleeding in the third trimester (Zhu et al, 2020). All the newborns were negative for SARS-CoV-2 (Zhu et al, 2020;Chen et al, 2020).…”

Section: Clinical Outcomes Of Pregnant Women With Covid-19mentioning

confidence: 99%

See 2 more Smart Citations