Clinical Adenocarcinoma of the Prostate in Patients Under 50 Years of Age

Tjaden, H.B.; Gulp, D.A.; Flocks, R.H.

doi:10.1016/s0022-5347(17)63840-0

Cited by 90 publications

(32 citation statements)

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“…This is important for two reasons; firstly it suggests that prostate cancer in young men undergoing radical prostatectomy is probably no worse than disease found in the older patient, contrary to earlier beliefs. 2,17,18 Secondly, it may support the claim that there is no difference in outcome following radical surgery across all age ranges. It also shows that older men in the UK do not have significantly more advanced disease compared to their younger counterparts, and that they do just as well after radical surgery with regards to biochemical recurrence.…”

Section: Discussionmentioning

confidence: 90%

PSA recurrence following radical prostatectomy is comparable for all age groups in the UK

Khan

Kaisary

Boustead

et al. 2005

Prostate Cancer Prostatic Dis

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Increasing numbers of men are being diagnosed with prostate cancer and undergo operative curative treatment. It has been suggested that outcome after radical prostatectomy (RP) may vary for different age groups. Objective: To investigate whether PSA recurrence-free survival after RP is related to age at operation for a cohort of English men. Methods: A total of 854 patients notes from four Urology units were audited for preoperative staging parameters and follow-up data obtained. The relationship of PSA, age, biopsy Gleason grade, clinical stage, era and institution on PSA recurrence-free survival was competitively assessed with a multivariate model. Results: Only preoperative PSA (Po0.0001) and biopsy Gleason grade (Po0.0001) were found to be strongly associated with PSA recurrence-free survival on multivariate analysis. PSA recurrence-free survival probabilities at 5 y for patients respectively. No significant difference of PSA recurrence-free survival between any of the age groups was found (Log-rank, P ¼ 0.8567). Conclusion: No significant difference of pathological variables or biochemical recurrence across the age groups was found. The widely held belief of poorer outcome in younger men selected for RP does not seem to be borne out by this study.

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Section: Discussionmentioning

confidence: 90%

PSA recurrence following radical prostatectomy is comparable for all age groups in the UK

Khan

Kaisary

Boustead

et al. 2005

Prostate Cancer Prostatic Dis

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“…In the pre-PSA era, younger patients with prostate cancer were reported to have a more aggressive disease, leading to the conclusion that a young age at diagnosis is associated with a worse disease outcome. 7,8 However, more recent studies demonstrated trends of older patients having worse prognoses or patient age not having any prognostic significance among RP cohorts. Freedland et al 11 reported that men of 50 years old or younger had significantly lower biochemical recurrence rates after RP than did older men after RP, based on multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports have demonstrated that younger men tend to have more aggressive prostate cancer and poorer outcomes after RP, whereas others have reported the contrary or indicated that age is not a significant prognostic factor regarding prostate cancer. 4,[7][8][9][10][11][12][13][14][15][16] We hypothesized that the prognostic significance of patient age may differ according to the clinicopathological profile of the tumour. Thus, we investigated the prognostic significance of patient age according to tumour aggressiveness in men who underwent RP for prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

Younger patients have poorer biochemical outcome after radical prostatectomy in high-risk prostate cancer

Hong¹,

Nam²,

Na³

et al. 2011

Asian J Androl

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The aim of this study was to investigate the prognostic significance of patient age with respect to tumour aggressiveness in men who underwent radical prostatectomy (RP) for prostate cancer. In this study, we reviewed the records of 743 patients who received RP without neoadjuvant or adjuvant therapy at our institution and were followed up for .2 years postoperatively. For our analyses, the patients were divided into two groups according to age: younger (,60 years) and older (o60 years). Through uni-and multivariate analyses, associations of various clinicopathological parameters, including biochemical recurrence-free survival, with patient age, were evaluated among all patients, and the patients were stratified according to their D'Amico risk classification. Among all subjects, younger (n5126) and older (n5617) patients showed no significant differences regarding pathological parameters and biochemical recurrence-free survival (P50.288). For the high-risk group (n5206), younger patients had a lower rate of biochemical recurrence-free survival following surgery than older patients (P50.017), despite the fact that no significant differences were observed regarding various known prognostic parameters between the two age groups. In addition, multivariate analysis revealed that age was an independent predictor of biochemical recurrence-free survival among the high-risk group (P50.003). Our results showed that relatively younger patients have a comparable biochemical outcome compared with their older counterparts following RP performed for prostate cancer. However, among patients with high-risk disease, younger patients have a worse biochemical outcome following RP compared with older patients.

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“…Studies performed before the PSA era point to a relationship between younger patients and more aggressive tumors (4,5). Other authors have found no differences in recurrence rates of the disease among younger patients.…”

Section: Commentsmentioning

confidence: 96%

“…Though most studies have historically demonstrated that younger men have more aggressive and lethal tumors (4,5), more recently other authors have pointed to a relationship between advanced age and highgrade, more voluminous lesions (6,7).…”

Section: Introductionmentioning

confidence: 99%

Prostate biopsy: is age important for determining the pathological features in prostate cancer?

et al. 2005

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Introduction: The influence of age on the aggressiveness of prostate cancer (PCa) is controversial. This study aims to assess the influence of age in determining the pathological features of biopsies from patients diagnosed with PCa.Patients and Methods: We selected 1422 patients with clinical suspicion of PCa; among them, 547 (38.5%) had received a diagnosis of adenocarcinoma. Patients were categorized into the following age groups: up to 50 years old, 51 to 60 years, 61 to 70 years, 71 to 80 years, and over 80 years. The evaluated variables were histological grade, presence of perineural invasion and estimate of tumor volume through measurement of the maximum percentage of tissue with cancer in one fragment and total percentage of tissue with cancer in the sample.Results: The mean age of patients was 66.4 years, with age range from 32 to 94 years. The estimate of tumor volume by maximum percentage of tissue with cancer in one fragment (p = 0.064), total percentage of tissue with cancer in the sample (p = 0.443), and Gleason score (p = 0.485) were not statistically different in relation to the age groups under study. The presence of perineural invasion occurred more frequently among the 50 years and 81 years age groups when compared with patients aged from 51 to 60 and from 61 to 80 years (p = 0.005).Conclusions: Age did not represent a determining factor for pathological findings concerning Gleason score and estimate of tumor volume by the variables in use.

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Clinical Adenocarcinoma of the Prostate in Patients Under 50 Years of Age

Cited by 90 publications

References 0 publications

PSA recurrence following radical prostatectomy is comparable for all age groups in the UK

PSA recurrence following radical prostatectomy is comparable for all age groups in the UK

Younger patients have poorer biochemical outcome after radical prostatectomy in high-risk prostate cancer

Prostate biopsy: is age important for determining the pathological features in prostate cancer?

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