Clindamycin colitis following Clindamycin therapy

Fibrin thrombi, a cause of clindamycin-associated colitis?

“…On the other hand, Butsch (1975) described vasculitis and capillary thrombosis in the submucosa in his case report of one patient. According to Steer (1975), electron microscopy showed fibrin within the WA~w ' vessels, at the site of ulceration, in four cases of clindamycin-associated pseudomembranous colitis.…”

A rapid blood lactate assay using a centrifugal analyser and 3-acetylpyridine-adenine dinucleotide.

“…In a recent study undertaken in our department (Bogomoletz, 1976), the presence of capillary fibrin thrombi was demonstrated in rectal biopsies from five patients with clindamycin-associated colitis, three with pseudomembranous colitis, and two with non-specific colitis (the latter form appears to be an even earlier lesion than 'type 1 lesion'). Furthermore, capillary thrombosis with vasculitis has been described in rectal biopsies of other cases of clindamycinassociated colitis (Butsch et al, 1975).…”

Crohn’s disease

“…Furthermore, capillary thrombosis with vasculitis has been described in rectal biopsies of other cases of clindamycinassociated colitis (Butsch et al, 1975 Sumner and Tedesco (1975) and also the series of Goulston and McGovern (1965). A cause of the discrepancy might be the interpretation of the eosinophilic exudate and the dilated capillaries seen just beneath the surface epithelium.…”