Clincopathological characteristics and treatment outcomes of oral leukoplakia by carbon dioxide laser excision in the elderly patients

Yang, Shih‐Wei; Lee, Yun‐Shien; Chang, Liang‐Che; Hwang, Cheng‐Cheng; Chen, Tai-An

doi:10.1002/hed.26074

Cited by 7 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean area of the OL with postoperative recurrence (4.81 ± 4.18 cm 2 ) was significantly larger than that of non-recurrent lesions (1.79 ± 2.40 cm 2 ). Not only in the present study, size of area was also a significant factor associated with postoperative recurrence in the studies of oral tongue leukoplakia [58], elderly patients with OL [59], and patients with oral erythroplakia [21]. In addition to being a critical factor related to recurrence, the area of OL was reported to be a risk factor affiliated with malignant change of OL in several studies [11,60,61].…”

Section: Discussionsupporting

confidence: 57%

A Retrospective Cohort Study of Oral Leukoplakia in Female Patients—Analysis of Risk Factors Related to Treatment Outcomes

Yang

Lee

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

Background: The aim of this study was to make a comparison of clinicopathological characteristics of oral leukoplakia between male and female patients following carbon dioxide laser excision for oral leukoplakia and analyze the factors associated with the treatment outcomes in female patients. Methods: Medical records of patients with oral leukoplakia receiving laser surgery from 2002 to 2020 were retrospectively reviewed and analyzed statistically. Results: A total of 485 patients were enrolled, including 412 male (84.95%) and 73 female (15.05%). Regarding the locations, the predilection site of oral leukoplakia in male patients was buccal mucosa (p = 0.0001) and that for women patients was tongue (p = 0.033). The differences of recurrence and malignant transformation between both sexes were not significant (p > 0.05). Among female patients, area of oral leukoplakia was the risk factor related to recurrence (p < 0.05). Clinical morphology and postoperative recurrence were the risk factors related to malignant transformation (p < 0.05). Conclusions: In comparison with male patients, there was no significant difference of the postoperative recurrence and malignant transformation of oral leukoplakia in female patients. Among the female patients, clinicians should pay more attention to large-sized and non-homogeneous leukoplakia, and postoperative recurrent lesions.

show abstract

Section: Discussionsupporting

confidence: 57%

A Retrospective Cohort Study of Oral Leukoplakia in Female Patients—Analysis of Risk Factors Related to Treatment Outcomes

Yang

Lee

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our previous work on the elderly patients (> 65 years) with OLK found that lesion area was one of the independent factors for postoperative recurrence. The cut-off area was 2.95 cm 2 [ 49 ]. In a retrospective cohort study of 144 patients with OLK in Amsterdam, treatment with CO 2 laser vaporization was done in 95 patients and observation in 49.…”

Section: Discussionmentioning

confidence: 99%

“…Pathological demonstration of dysplasia is another important issue for OLK. The occurrence of dysplasia in an OLK lesion indicates a high probability of postoperative recurrence [ 23 , 49 ] or malignant transformation [ 21 , 54 , 55 , 57 ] in several studies. However, there were results contradictory to the concept, and those authors thought that the presence of any degree of epithelial dysplasia did not have any influence on the risk of postoperative recurrence [ 35 , 36 , 38 ] or malignant development [ 17 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

et al. 2021

Self Cite

View full text Add to dashboard Cite

Objectives The tongue is identified as a high-risk site for oral leukoplakia and malignant transformation. The purpose of this study is to investigate the clinicopathological characteristics and treatment outcomes of tongue leukoplakia and assess the factors related to recurrence and malignant transformation. Materials and methods One hundred and forty-four patients who received carbon dioxide laser surgery for tongue leukoplakia from 2002 to 2019 were analyzed statistically. Results The follow-up period was 54.90 ± 54.41 months. Thirty patients showed postoperative recurrence (20.83%), and 12 patients developed malignant transformation (8.33%). The annual transformation rate was 2.28%. Univariate analysis showed that a history of head and neck cancer, size of lesion area, clinical appearance, and pathology were significant factors for both recurrence and malignant transformation. In the multivariate logistic regression, a history of head and neck cancer and size of lesion area were independent prognostic factors for recurrence, and a history of head and neck cancer was the only independent factor for postoperative malignant change. Conclusions Clinicians should adopt more aggressive strategies for tongue leukoplakia patients with a history of head and neck cancer. Clinical relevance These results may help clinicians gain a better understanding of oral tongue leukoplakia.

show abstract

“…Yang et al [35] performed a retrospective study on elderly patients (older than 65 years) suffering from oral leukoplakia (OL) who received surgical excision of OL lesions with CO 2 laser. A total of 69 subjects were included in the study, with a mean age of 71.2 ± 4.9.…”

Section: Co 2 Laser Treatment In the Case Of Oral Leukoplakiamentioning

confidence: 99%

A Review of CO2 Laser-Mediated Therapy for Oral Mucosal Lesions

Condor

Culcitchi²,

Blum

et al. 2021

Applied Sciences

View full text Add to dashboard Cite

(1) Background: Several studies investigating the clinical outcomes of potentially premalignant oral epithelial lesions treated with CO2 lasers have been published over the last decades. (2) Methods: A systematic research review was performed for studies published between 2011 and 2021 in the PubMed, Science Direct, and Google Scholar databases. (3) Results: Initially, the search identified 52 relevant articles. The primary analysis of the titles and abstracts eliminated 22 articles, leaving 30 articles whose full texts were examined. A total of 22 articles met the inclusion criteria. The studies were classified into 3 categories. (4) Conclusions: After evaluating the results of all the studies included in this review, an initial general statement can be made, namely that CO2 lasers are a treatment option worth taking into consideration when approaching oral mucosal lesions. When compared to other types of lasers used in dental practice, the CO2 laser stands out due to its many advantages.

show abstract

Clincopathological characteristics and treatment outcomes of oral leukoplakia by carbon dioxide laser excision in the elderly patients

Cited by 7 publications

References 45 publications

A Retrospective Cohort Study of Oral Leukoplakia in Female Patients—Analysis of Risk Factors Related to Treatment Outcomes

A Retrospective Cohort Study of Oral Leukoplakia in Female Patients—Analysis of Risk Factors Related to Treatment Outcomes

Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

A Review of CO2 Laser-Mediated Therapy for Oral Mucosal Lesions

Contact Info

Product

Resources

About