Climatic factors and lower respiratory tract infection due to respiratory syncytial virus in hospitalised infants in northern Spain

Lapeña, Santiago; Robles, Mariá Belén; Castañón, Leticia; Martínez, Juan Pablo; Reguero, Sofiá; Alonso, María Paz; Fernández, Isabel

doi:10.1007/s10654-004-4539-6

Cited by 38 publications

(32 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, regression models using mean temperature in the preceding month model were not established. In general, the trend of associations between climate factors and respiratory pathogen activity varies with geographic location [35,[48][49][50][51][52][53]. In this study, RSV and HMPV had similar seasonal distribution patterns, and both were negatively correlated with sunshine duration ( Table 2, Fig.…”

Section: Discussionmentioning

confidence: 50%

Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey

Liu

Chen

Tan

et al. 2019

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

To investigate the features of paramyxovirus respiratory syncytial virus (RSV), parainfluenza virus (PIV), and human metapneumovirus (HMPV) infection and determine the effect of meteorological conditions in Guangzhou, a subtropical region of southern China. We collected 11,398 respiratory samples from hospitalized pediatric patients with acute respiratory illness between July 2009 and June 2016 in Guangzhou. The samples were tested simultaneously for 18 respiratory pathogens using real-time PCR. Local meteorological data were also collected for correlation analysis. Of 11,398 patients tested, 5606 (49.2%) patients tested positive for one or more pathogens; RSV, PIV, and HMPV were the first, sixth, and ninth most frequently detected pathogens, in 1690 (14.8%), 502 (4.4%), and 321 (2.8%) patients, respectively. A total 17.9% (4605/5606) of patients with positive results had coinfection with other pathogens. Significant differences were found in the prevalence of RSV, PIV, and HMPV among all age groups (p < 0.001). RSV and HMPV had similar seasonal patterns, with two prevalence peaks every year. PIV appeared alternatively with RSV and HMPV. Multiple linear regression models were established for RSV, PIV, and HMPV prevalence and meteorological factors (p < 0.05). RSV and PIV incidence was negatively correlated with monthly mean relative humidity; RSV and HMPV incidence was negatively correlated with sunshine duration; PIV incidence was positively correlated with mean temperature. We described the features of paramyxovirus infection in a subtropical region of China and highlighted the correlation with meteorological factors. These findings will assist public health authorities and clinicians in improving strategies for controlling paramyxovirus infection.

show abstract

Section: Discussionmentioning

confidence: 50%

Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey

Liu

Chen

Tan

et al. 2019

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

show abstract

“…However, a variety of factors could influence either the viral survival or infectivity of respiratory viruses, such as meteorological factors, seasonal variations in social behavior, air pollution, and subgroup-specific immune responses throughout (11,13,22,39). Indirectly such factors are important in the rate of detection of respiratory viruses from infants with lower respiratory tract illnesses.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression of Nucleic Acid-Sensing Pattern Recognition Receptors in Children Hospitalized for Respiratory Syncytial Virus-Associated Acute Bronchiolitis

Scagnolari

Midulla

Pierangeli

et al. 2009

Clin Vaccine Immunol

View full text Add to dashboard Cite

Given the critical role of pattern recognition receptors (PRRs) in acid nucleic recognition in the initiation of innate immunity and the orchestration of adaptive immunity, the aim of this study was to determine whether any heterogeneity of PRR expression in the airway tracts of infants with respiratory syncytial virus (RSV) infection might explain the broad clinical spectrum of RSV-associated bronchiolitis in infants. For this purpose, the levels of melanoma differentiation-associated protein-5 (MDA-5), retinoic acid inducible gene-1 (RIG-1), and Toll-like receptor 3 (TLR-3), TLR-7, TLR-8, and TLR-9 mRNAs were evaluated, using TaqMan quantitative reverse transcription-PCR, in cells from nasopharyngeal washes collected from 157 infants suffering from acute bronchiolitis whether or not they were associated with respiratory viruses. High interindividual variability was observed in both virus-positive and -negative infants; however, the relative gene expression levels of MDA-5, RIG-1, TLR-7, and TLR-8 were significantly higher in the virus-infected group, whereas the expression levels of TLR-3 and TLR-9 were not significantly different. The differences in the gene expression of MDA-5, RIG-1, TLR-7, and TLR-8 were more evident in infants with RSV infection than in those with bocavirus or rhinovirus infection. In RSV-infected infants, PRR-mRNA levels also were analyzed in relation to interferon protein levels, viral load, clinical severity, days of hospitalization, age, and body weight. A significant positive correlation was observed only between RSV viral load and RIG-1 mRNA levels. These findings provide the first direct evidence that, in infants with respiratory virus-associated bronchiolitis, especially RSV, there are substantial changes in PRR gene expression; this likely is an important determinant of the clinical outcome of bronchiolitis.

show abstract

“…A study performed in Spain (Lapena et al, 2005) indicated that low temperature and low absolute humidity were positively associated with the number of RSV cases and low absolute humidity was independently related to RSV infection. Worldwide, RSV peaks at two temperature intervals: between 2-6°C in temperate regions and 24-30°C in tropical regions.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Diagnosis of Human Respiratory Syncytial Virus Infections

Akhter¹,

Johani²

2011

Human Respiratory Syncytial Virus Infection

View full text Add to dashboard Cite

Climatic factors and lower respiratory tract infection due to respiratory syncytial virus in hospitalised infants in northern Spain

Abstract: Low absolute humidity was independently associated with hospital admission of infants with lower respiratory tract infection due to RSV.

Cited by 38 publications

References 24 publications

Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey

Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey

Gene Expression of Nucleic Acid-Sensing Pattern Recognition Receptors in Children Hospitalized for Respiratory Syncytial Virus-Associated Acute Bronchiolitis

Epidemiology and Diagnosis of Human Respiratory Syncytial Virus Infections

Contact Info

Product

Resources

About