Based on sea surface height anomaly (SSHA) from satellite altimeter and microwave radiometer datasets, this study investigates atmospheric responses to oceanic eddies in four subdomains of the North Pacific Ocean with strongest eddy activity: Kuroshio Extension (KE), Subtropical Front (SF), California Coastal Current (CC) and Aleutian Islands (AI). Analyses show that anticyclonic eddies cause sea surface temperature, surface wind speed and precipitation rate to increase in all four subdomains, and vice versa. Through a further examination of the regional dependence of atmospheric responses to oceanic eddies, it is found that the strongest and the weakest surface wind speed responses (in winter and summer) are observed in the KE and AI region, respectively. For precipitation rate, seasonal variation of the atmospheric responses to oceanic eddies is strongest in winter and weakest in summer in the KE, CC and AI regions, but stronger in summer in the SF area. The reasons for such regional dependence and seasonality are the differences in the strength of SST anomalies, the vertical kinetic energy flux and atmospheric instability in the four subdomains. 149 the 90-day high pass-filtered surface EKE averaged from 2002 to 2010 in the North Pacific. The highest 150 EKE occurs in the KE and SF regions [42-43]. In addition, compared with adjacent areas, EKE is also 151 high in the AI and CC regions. The largest EKE in the KE region is primarily caused by the strong 152 horizontal shear and the meandering of the Kuroshio path [42]. The higher EKE in the SF region is 153 predominantly modulated by the baroclinic instability of the background currents [44]. The CC 154 region is characterized by strong eddy activity where the persistent equatorward wind causes coastal 155 upwelling fronts. Instability of these upwelling fronts results in eddy generation. The instability of 156 the coast shelf trapped jet causes the eddy formation in the AI region. One can see that the eddy 157 generation mechanisms are varied in the four subdomains, which could cause a difference in 158 mesoscale air-sea interaction characteristics in the four regions.159 160 Figure 2. 90-day high pass-filtered eddy kinetic energy (EKE; shaded) averaged from January 2002 to 161 December 2010. The black dashed lines delineate the four subdomains in this study.Remote Sens. 2020. 4 of 18 0.05 °C (for anticyclonic eddies), and radii larger than 20 km, are selected. As a result, there are about 138 14677, 19636, 16684 and 12220 cyclonic eddies, and 14469, 22043, 16747 and 13195 anticyclonic eddies 139 in the KE, SF, CC and AI regions, respectively. The matching method is adopted from Ma et al. [24]. 157 generation mechanisms are varied in the four subdomains, which could cause a difference in 158 mesoscale air-sea interaction characteristics in the four regions. Remote Sens. 2020. 5 of 18 Satellite altimetry data provides an opportunity to characterize eddies in terms of their basic 163 parameters such as polarity, lifetime, size, vorticity and moving speed in the ...