Climate change and epilepsy: Insights from clinical and basic science studies

Gulcebi, Medine I.; Bartolini, Emanuele; Lee, Omay; Lisgaras, Christos Panagiotis; Onat, Filiz; Mifsud, Janet; Striano, Pasquale; Vezzani, Annamaria; Hildebrand, Michael S.; Jiménez‐Jiménez, Diego; Junck, Larry; Lewis-Smith, David; Scheffer, Ingrid E.; Thijs, Roland D.; Zuberi, Sameer M.; Blenkinsop, Stephen; Fowler, Hayley J.; Foley, Aideen; Sisodiya, Sanjay M.

doi:10.1016/j.yebeh.2021.107791

Cited by 34 publications

(17 citation statements)

References 157 publications

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Section: Discussionmentioning

confidence: 99%

“…Body temperature plays a critical role in determining seizure threshold and seizure-related brain damage [23]. High-grade fever and febrile illnesses are often known to worsen seizure control (for most convulsive seizure types) by lowering the seizure threshold [23]. In this context, epileptic spasm is a unique seizure semiology where spontaneous resolution has been reported after fever (pyretotherapy) [10,24].…”

Section: Discussionmentioning

confidence: 99%

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COVID-19 in Children with West Syndrome: An Ambispective Study

et al. 2022

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ObjectivesTo study the course of West syndrome (WS) and coronavirus disease-19 in children with WS who contracted SARS-CoV-2 infection. Methods This ambispective study was conducted at a tertiary-care center in North India between December 2020 and August 2021 after approval from the Institute Ethics Committee. Five children with WS, positive for COVID-19 based on RT-PCR, fulfilled the inclusion criteria. Results One child with COVID-19 during the first wave was retrospectively included while four children (of the 70 children screened) were prospectively enrolled. The median age at onset of epileptic spasms was 7 mo (2 boys), and that at presentation with COVID-19 was 18.5 mo. Three had underlying acquired structural etiology. Three were in remission following standard therapy, while two had ongoing spasms at the time of COVID-19 illness. During the illness, two of those in remission continued to be in remission while one child had a relapse. The children with ongoing epileptic spasms had variable course [one had persistent spasms and other had transient cessation lasting 3 wk from day 2 of COVID-19 illness, but electroencephalography (on day 8 of COVID-19 illness) continued to show hypsarrhythmia]. Fever was the most typical symptom (and sometimes the only symptom) of COVID-19, with a duration ranging from 1-8 d. Two children had moderate COVID-19 illness requiring hospitalization, while the rest had a mild illness. All the affected children had complete recovery from COVID-19. ConclusionThe severity of COVID-19 illness in children with WS is often mild, while the subsequent course of WS is variable.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

COVID-19 in Children with West Syndrome: An Ambispective Study

et al. 2022

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“…Second, cold-related changes in autonomic nervous function may influence the onset of epileptic seizures [35]. Third, hypothermia directly affects a person's physiological state, but it may also indirectly cause socioeconomic status changes due to increased social stress, fatigue, and sleep deprivation, which are common triggers of epilepsy [36]. Fourth, low temperatures increase air pressure because cold air is denser than warm air.…”

Section: Discussionmentioning

confidence: 99%

Low apparent temperature increases the number of epilepsy-related clinic visits in a humid subtropical region: a time-series study

Sun

Zhang²,

Wang³

et al. 2022

Environ. Res. Commun.

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Background: At present, the effect of apparent temperature (AT) on epilepsy has not been confirmed. Therefore, we conducted this study in Hefei, China, a city in a humid subtropical region, to investigate the effects of AT on the daily number of epilepsy-related clinic visits. Methods: A time-series analysis of the number of daily epilepsy clinic visits during 2015-2020 was performed using a quasi-Poisson regression model combined with a distributed lag nonlinear model (DLNM). Time trends, days of the week, relative humidity, and PM2.5 concentration were adjusted for in the model. Subgroup analyses were performed by sex and age. Results: A total of 28,020 epilepsy-related clinic visits were reported by the hospital during the study period. Low AT showed significant negative and delayed effects on the number of epilepsy clinic visits, but no such effects were observed with high AT. The median apparent temperature (17 °C) was used as the reference, and the single-day lag effect of low AT (5th percentile, -1.5 °C) on the number of epilepsy clinic visits peaked on lag day 1, with a relative risk (RR) of 1.055 (95% CI: 1.015–1.097). The cumulative effect of low AT was most obvious on lag days 0-12, with a maximum RR of 1.451 (95% CI: 1.180–1.783). Males and young adults (0-14 years and 15-29 years) were more likely to be affected by low AT. Conclusions: We found that low AT led to an increase in the number of epilepsy-related clinic visits. This result provides an important scientific basis for the allocation of outpatient medical resources and the development of interventions.

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“…The global mean surface temperature (GMST) in 2020 was 1.2 ± 0.1 °C warmer than the pre-industrial baseline, making 2020 one of the three warmest years on record [1] . Global warming has had serious impacts on the ecosystem and human society [2][3][4] . The Paris Agreement proposes that the rise of GMST in this century should be limited to 2 °C above the pre-industrial baseline and that more efforts should be made to limit the rise in temperature to 1.5 °C [5] .…”

Section: Introductionmentioning

confidence: 99%

Assessment of operational carbon emission reduction potential of green building technologies

Yumin¹,

Liang²,

Pan³

et al. 2021

Preprint

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The concept of green building plays an important role in carbon emission reduction. This paper focuses on the energy conservation in the building operational phase to assess the carbon emission reduction potential of several major green building technologies. Energy use intensity is simulated using EnergyPlus with prototypical models of various green building scenarios for office buildings and hotels in Shanghai and Harbin. The carbon emission factor is calculated according to the energy structure in the building sector in China. Results shows that passive technologies such as daylighting and natural ventilation can bring significant reductions in carbon emissions followed by retrofitting of building envelopes and energy efficiency improvement of HVAC equipment. Covering all green building technologies considered, the total operational carbon emission reduction rate can reach nearly 19% for office buildings and 25% for hotels.

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Climate change and epilepsy: Insights from clinical and basic science studies

Cited by 34 publications

References 157 publications

COVID-19 in Children with West Syndrome: An Ambispective Study

COVID-19 in Children with West Syndrome: An Ambispective Study

Low apparent temperature increases the number of epilepsy-related clinic visits in a humid subtropical region: a time-series study

Assessment of operational carbon emission reduction potential of green building technologies

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