Click Synthesis of Some mono/bis 1,2,3-Triazoles with Ester Linkage and their Microbicidal Activity

Kaushik, C. P.; Pahwa, Ashima

doi:10.14233/ajchem.2017.20671

Cited by 3 publications

(2 citation statements)

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“…Keeping these observations in mind and in continuation of our enduring research on synthesis and biological studies of 1,4‐disubstituted 1,2,3‐triazoles , herein, we focused on synthesis of a series of (1‐(2‐(benzyloxy)‐2‐oxoethyl)‐1 H ‐1,2,3‐triazol‐4‐yl)methyl benzoate analogues ( 5a – 5t ) with ester functionality via Cu(I) catalyzed click reaction between prop‐2‐yn‐1‐yl benzoates and benzyl 2‐azidoacetates. All the synthesized compounds were characterized by spectral techniques FT‐IR, 1 H NMR, 13 C NMR spectroscopy, and high‐resolution mass spectrometry (HRMS) and also examined for antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Evaluation of (1‐(2‐(Benzyloxy)‐2‐oxoethyl)‐1H‐1,2,3‐triazol‐4‐yl)methyl Benzoate Analogues

Kaushik

Pahwa

Kumar

et al. 2018

Journal of Heterocyclic Chem

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A convenient one pot synthesis of 20 (1‐(2‐(benzyloxy)‐2‐oxoethyl)‐1H‐1,2,3‐triazol‐4‐yl)methyl benzoate analogues (5a–5t) with ester functionality was carried out via Cu(I) catalyzed click reaction between prop‐2‐yn‐1‐yl benzoates and benzyl 2‐azidoacetates. The structure of synthesized triazoles were explicated by various spectral techniques like FT‐IR, 1H NMR, 13C NMR, and high‐resolution mass spectrometry and evaluated for in vitro antimicrobial potential against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Candida albicans, and Aspergillus niger. Most of synthesized triazole derivatives exhibited average to excellent activity against tested microbial strains.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Evaluation of (1‐(2‐(Benzyloxy)‐2‐oxoethyl)‐1H‐1,2,3‐triazol‐4‐yl)methyl Benzoate Analogues

Kaushik

Pahwa

Kumar

et al. 2018

Journal of Heterocyclic Chem

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“…It helps to envisage the biological spectrum of newly designed compounds from structural and electronic parameters, contributing for the drug discovery processes. Encouraged from above considerations, for the development of effective microbicidal substituted 1,2,3-triazoles [23][24][25], herein, we describe the QSAR studies of 20 ester linked 1,4-disubstituted 1,2,3-triazoles (1a-1t) possessing antimicrobial activities reported earlier [26].…”

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confidence: 99%

QSAR Studies on Microbicidal Activity of Disubstituted 1,2,3-Triazoles having Ester Linkages

Kaushik¹,

Pahwa²,

Kumar³

et al. 2018

Asian J. Chem.

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Over the past few years, continuous emergence of resistance in microorganisms along with side effects towards existing antimicrobials has become major health concern for the community. Various types of infections are increasing day by day due to these multidrug resistant bacteria and fungi. Owing to this, design and development of new structural leads has become major challenge for medicinal researchers. This justifies the attempt for synthesis of new, effective and safer antibacterial and antifungal agents with novel mode of action to combat newer microbial infections [1,2]. Triazoles correspond to class of bioactive heterocycles and have been recognized as key structural entity in several molecules of pharmaceutical importance [3]. These scaffolds reflected their role as antibacterial [4,5], antifungal [6], anti-HIV [7], anticancer [8,9], antitubercular [10,11], anticonvulsant [12], antiallergic [13], antioxidant [14], antiviral [15], antimalarial [16] agents etc., in the field of medicinal chemistry. Inspite of the pharmaceutical applications, these triazole derivatives also found to possess industrial importance as optical brighteners, dyestuffs, photostabilizers, agrochemicals and corrosion inhibitors [17,18]. In the past, various synthetic approaches have been developed for the synthesis of 1,2,3triazoles, however, Cu(I) catalyzed cycloaddition between

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Efficient synthesis, antitubercular and antimicrobial evaluation of 1,4-disubstituted 1,2,3-triazoles with amide functionality

et al. 2019

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Click Synthesis of Some mono/bis 1,2,3-Triazoles with Ester Linkage and their Microbicidal Activity

Cited by 3 publications

References 2 publications

Synthesis and Antimicrobial Evaluation of (1‐(2‐(Benzyloxy)‐2‐oxoethyl)‐1H‐1,2,3‐triazol‐4‐yl)methyl Benzoate Analogues

Synthesis and Antimicrobial Evaluation of (1‐(2‐(Benzyloxy)‐2‐oxoethyl)‐1H‐1,2,3‐triazol‐4‐yl)methyl Benzoate Analogues

QSAR Studies on Microbicidal Activity of Disubstituted 1,2,3-Triazoles having Ester Linkages

Efficient synthesis, antitubercular and antimicrobial evaluation of 1,4-disubstituted 1,2,3-triazoles with amide functionality

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