QSAR Studies on Microbicidal Activity of Disubstituted 1,2,3-Triazoles having Ester Linkages

Abstract

Over the past few years, continuous emergence of resistance in microorganisms along with side effects towards existing antimicrobials has become major health concern for the community. Various types of infections are increasing day by day due to these multidrug resistant bacteria and fungi. Owing to this, design and development of new structural leads has become major challenge for medicinal researchers. This justifies the attempt for synthesis of new, effective and safer antibacterial and antifungal agents with novel mode of action to combat newer microbial infections [1,2]. Triazoles correspond to class of bioactive heterocycles and have been recognized as key structural entity in several molecules of pharmaceutical importance [3]. These scaffolds reflected their role as antibacterial [4,5], antifungal [6], anti-HIV [7], anticancer [8,9], antitubercular [10,11], anticonvulsant [12], antiallergic [13], antioxidant [14], antiviral [15], antimalarial [16] agents etc., in the field of medicinal chemistry. Inspite of the pharmaceutical applications, these triazole derivatives also found to possess industrial importance as optical brighteners, dyestuffs, photostabilizers, agrochemicals and corrosion inhibitors [17,18]. In the past, various synthetic approaches have been developed for the synthesis of 1,2,3triazoles, however, Cu(I) catalyzed cycloaddition between