Click‐evoked auditory brainstem responses and autism spectrum disorder: A meta‐analytic review

Talge, Nicole M.; Tudor, Brooke M.; Kileny, Paul R.

doi:10.1002/aur.1946

Cited by 27 publications

(21 citation statements)

References 78 publications

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“…The ABR has provided the most insight into the function of brainstem centers in ASD. The majority of studies of the ABR in subjects with ASD over the past 40 years provide evidence that subjects with ASD have smaller amplitudes in waves I, II, III, IV, and V (Ornitz et al, 1972 ; Gillberg et al, 1983 ; Martineau et al, 1987 , 1992 ; Klin, 1993 ), longer latencies between waves I-III and waves I-V (Taylor et al, 1982 ), and longer latencies/slower responses (Ornitz, 1969 ; Student and Sohmer, 1978 ; Rosenblum et al, 1980 ; Sohmer, 1982 ; Tanguay et al, 1982 ; Gillberg et al, 1983 ; Sersen et al, 1990 ; Thivierge et al, 1990 ; Wong and Wong, 1991 ; Maziade et al, 2000 ; Kwon et al, 2007 ; Roth et al, 2012 ; Azouz et al, 2014 ; Taş et al, 2017 ; Miron et al, 2018 , 2021 ; Ramezani et al, 2019 ; Delgado et al, 2021 ; reviewed in Talge et al, 2018 ). These longer latency and lower amplitude responses have been attributed to the immaturity of brainstem circuits (Li et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Mansour

Burchell

Kulesza

2021

Front. Integr. Neurosci.

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by repetitive behaviors, poor social skills, and difficulties with communication. Beyond these core signs and symptoms, the majority of subjects with ASD have some degree of auditory and vestibular dysfunction. Dysfunction in these sensory modalities is significant as normal cognitive development depends on an accurate representation of our environment. The hearing difficulties in ASD range from deafness to hypersensitivity and subjects with ASD have abnormal sound-evoked brainstem reflexes and brainstem auditory evoked potentials. Vestibular dysfunction in ASD includes postural instability, gait dysfunction, and impaired gaze. Untreated vestibular dysfunction in children can lead to delayed milestones such as sitting and walking and poor motor coordination later in life. Histopathological studies have revealed that subjects with ASD have significantly fewer neurons in the auditory hindbrain and surviving neurons are smaller and dysmorphic. These findings are consistent with auditory dysfunction. Further, the cerebellum was one of the first brain structures implicated in ASD and studies have revealed loss of Purkinje cells and the presence of ectopic neurons. Together, these studies suggest that normal auditory and vestibular function play major roles in the development of language and social abilities, and dysfunction in these systems may contribute to the core symptoms of ASD. Further, auditory and vestibular dysfunction in children may be overlooked or attributed to other neurodevelopmental disorders. Herein we review the literature on auditory and vestibular dysfunction in ASD. Based on these results we developed a brainstem model of central auditory and vestibular dysfunction in ASD and propose that simple, non-invasive but quantitative testing of hearing and vestibular function be added to newborn screening protocols.

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Section: Introductionmentioning

confidence: 99%

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Mansour

Burchell

Kulesza

2021

Front. Integr. Neurosci.

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“…A number of studies have reported abnormal auditory processing in ASD and/or other disorders such as schizophrenia, measured by magnetoencephalography (MEG), electroencephalography (EEG), and auditory brainstem responses (ABR). Previous electrophysiology studies have also observed prolonged latencies of other components in clinical populations compared to neurotypically developing controls, with delayed auditory responses observed at mid-brainstem levels as well as primary/secondary auditory cortex [Oram Cardy et al, 2005, Roberts et al, 2012, Rojas., 2014, Kikuchi et al, 2015, Damaso et al, 2015, Berman et al, 2016, Schwartz et al, 2018, Talge et al, 2018, Matsuzaki et al, 2019]. The ability to detect an auditory change (e.g., pitch, frequency, syllable) is an important feature of the auditory system, with impaired change detection likely contributing to downstream language and communication impairment [Schwartz et al, 2018].…”

Section: Introductionmentioning

confidence: 99%

Abnormal auditory mismatch fields are associated with communication impairment in both verbal and minimally verbal/nonverbal children who have autism spectrum disorder

et al. 2019

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Abnormal auditory discrimination neural processes, indexed by mismatch fields (MMFs) recorded by magnetoencephalography (MEG), have been reported in verbal children with ASD. Association with clinical measures indicates that delayed MMF components are associated with poorer language and communication performance. At present, little is known about neural correlates of language and communication skills in extremely language impaired (minimally-verbal/non-verbal) children who have ASD: ASD-MVNV. It is hypothesized that MMF delays observed in language-impaired but nonetheless verbal children with ASD will be exacerbated in ASD-MVNV. The present study investigated this hypothesis, examining MMF responses bilaterally during an auditory oddball paradigm with vowel stimuli in ASD-MVNV, in a verbal ASD cohort without cognitive impairment and in typically developing (TD) children. The verbal ASD cohort without cognitive impairment was split into those demonstrating considerable language impairment (CELF core language index <85; “ASD-LI”) versus those with less or no language impairment (CELF CLI >85; “ASD-V”). Eighty-four participants (8-12years) were included in final analysis: ASD-MVNV: n=9, 9.67±1.41years, ASD: n=48, (ASD-V: n=27, 10.55±1.21years, ASD-LI: n=21, 10.67±1.20years) and TD: n=27, 10.14±1.38years. Delayed MMF latencies were found bilaterally in ASD-MVNV compared to verbal ASD (both ASD-V and ASD-LI) and TD children. Delayed MMF responses were associated with diminished language and communication skills. Furthermore, whereas the TD children showed leftward lateralization of MMF amplitude, ASD-MVNV and verbal ASD (ASD-V and ASD-LI) showed abnormal rightward lateralization. Findings suggest delayed auditory discrimination processes and abnormal rightward laterality as objective markers of language/communication skills in both verbal and MVNV children who have ASD.

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“…Many studies have demonstrated auditory processing differences in ASD in terms of both response amplitude and timing that are seen from the earliest brainstem responses [e.g., Talge, Tudor, & Kileny, ] to late cortical responses [see Bomba & Pang, ; Jeste & Nelson, ; O'connor, for reviews]. Tharpe et al [] showed that, despite normal auditory thresholds, brain stem responses were more variable in ASD.…”

Section: Introductionmentioning

confidence: 99%

Differential Altered Auditory Event‐Related Potential Responses in Young Boys on the Autism Spectrum With and Without Disproportionate Megalencephaly

et al. 2019

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Autism spectrum disorder (ASD), characterized by impairments in social communication and repetitive behaviors, often includes altered responses to sensory inputs as part of its phenotype. The neurobiological basis for altered sensory processing is not well understood. The UC Davis Medical Investigation of Neurodevelopmental Disorders Institute Autism Phenome Project is a longitudinal, multidisciplinary study of young children with ASD and age-matched typically developing (TD) controls. Previous analyses of the magnetic resonance imaging data from this cohort have shown that $15% of boys with ASD have disproportionate megalencephaly (DM) or brain size to height ratio, that is 1.5 standard deviations above the TD mean. Here, we investigated electrophysiological responses to auditory stimuli of increasing intensity (50-80 dB) in young toddlers (27-48 months old). Analyses included data from 36 age-matched boys, of which 24 were diagnosed with ASD (12 with and 12 without DM; ASD-DM and ASD-N) and 12 TD controls. We found that the two ASD subgroups differed in their electrophysiological response patterns to sounds of increasing intensity. At early latencies (55-115 ms), ASD-N does not show a loudness-dependent response like TD and ASD-DM, but tends to group intensities by soft vs. loud sounds, suggesting differences in sensory sensitivity in this group. At later latencies (145-195 ms), only the ASD-DM group shows significantly higher amplitudes for loud sounds. Because no similar effects were found in ASD-N and TD groups, this may be related to their altered neuroanatomy. These results contribute to the effort to delineate ASD subgroups and further characterize physiological responses associated with observable phenotypes.Lay summary: Approximately 15% of boys with ASD have much bigger brains when compared to individuals with typical development. By recording brain waves (electroencephalography) we compared how autistic children, with or without big brains, react to sounds compared to typically developing controls. We found that brain responses in the big-brained group are different from the two other groups, suggesting that they represent a specific autism subgroup.

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Click‐evoked auditory brainstem responses and autism spectrum disorder: A meta‐analytic review

Cited by 27 publications

References 78 publications

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Abnormal auditory mismatch fields are associated with communication impairment in both verbal and minimally verbal/nonverbal children who have autism spectrum disorder

Differential Altered Auditory Event‐Related Potential Responses in Young Boys on the Autism Spectrum With and Without Disproportionate Megalencephaly

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