Clenbuterol attenuates immune reaction to lipopolysaccharide and its relationship to anhedonia in adolescents

Nguyen, Tai D.; Pick, Danielle; Patel, Manishkumar; Xie, Hui; Kim‐Schulze, Seunghee; Gabbay, Vilma

doi:10.1016/j.bbi.2022.07.163

Cited by 7 publications

(6 citation statements)

References 100 publications

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“… Qu et al (2022) observed that LPS-containing taxa, such as Proteobacteria , Gammaproteobacteria , Enterobacteriaceae , and Escherichia–Shigella , were positively associated with NCDs. Lipopolysaccharide (LPS), an endotoxin generated by G-bacteria, has previously been identified its relationship with the production of gut inflammation cytokines ( Gao et al, 2022 ; Nguyen et al, 2022 ). On the contrary, they also determined that SCFA-producing bacteria, which Prevotella represents, decreased significantly in patients with NCDs.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota-generated short-chain fatty acids are involved in para-chlorophenylalanine-induced cognitive disorders

Liu

Sun

et al. 2022

Front. Microbiol.

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Neurocognitive disorders (NCDs) include complex and multifactorial diseases that affect many patients. The 5-hydroxytryptamine (5-HT) neuron system plays an important role in NCDs. Existing studies have reported that para-chlorophenylalanine (PCPA), a 5-HT scavenger, has a negative effect on cognitive function. However, we believe that PCPA may result in NCDs through other pathways. To explore this possibility, behavioral tests were performed to evaluate the cognitive function of PCPA-treated mice, suggesting the appearance of cognitive dysfunction and depression-like behavior. Furthermore, 16S rRNA and metabolomic analyses revealed that dysbiosis and acetate alternation could be related to PCPA-induced NCDs. Our results suggest that not only 5-HT depletion but also dysbiosis and acetate alternation contributed to PCPA-related NCDs. Specifically, the latter promotes NCDs by reducing short-chain fatty acid levels. Together, these findings provide an alternative perspective on PCPA-induced NCDs.

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Section: Discussionmentioning

confidence: 99%

Gut microbiota-generated short-chain fatty acids are involved in para-chlorophenylalanine-induced cognitive disorders

Liu

Sun

et al. 2022

Front. Microbiol.

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“…Second, this study was a cross-sectional design and was unable to explore dynamic changes in inflammatory factors and brain structure, precluding causal inferences. Third, although the distinctions of different aspects of anhedonia on brain structure and inflammation have been revealed ( 64 , 65 ), the present study did not investigate the effects of different aspects of anhedonia due to the modest sample size. Finally, only three inflammatory cytokines, including IL-1β, IL-6, and TNF-α, were measured in this study, consequently, the findings of inflammatory characteristics in MDD patients with anhedonia were quite limited.…”

Section: Limitationmentioning

confidence: 86%

Increased plasma levels of IL-6 are associated with striatal structural atrophy in major depressive disorder patients with anhedonia

Jia

et al. 2022

Front. Psychiatry

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BackgroundAnhedonia, as the core endophenotype of major depressive disorder (MDD), is closely related to poor prognosis, but the mechanism of this feature remains to be understood. The aim of this study was to investigate the inflammatory factors and brain structural alterations in MDD patients with anhedonia and evaluate the relationship between these factors.MethodsWe assessed the plasma levels of interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in MDD patients with anhedonia (n = 22), MDD patients without anhedonia (n = 20), and age- and sex-matched healthy controls (HCs, n = 20) by enzyme-linked immunosorbent assay kits. All participants underwent high-resolution brain magnetic resonance imaging (MRI) scans, and voxel-based morphometry (VBM) was used to evaluate their gray matter volume (GMV). We compared inflammatory factors and GMV among the three groups and explored their relationships in MDD patients with anhedonia.ResultsCompared with those of HCs, plasma levels of IL-1β were increased in patients with MDD independent of anhedonia features, while plasma levels of IL-6 were elevated in MDD patients with anhedonia only. Meanwhile, MDD patients with anhedonia exhibited reduced GMV in the left striatal structures compared to MDD patients without anhedonia and HCs. Moreover, a significant association was observed between increased plasma levels of IL-6 and decreased GMV of the left putamen in MDD patients with anhedonia.ConclusionsThe present research outcomes suggest that anhedonia is associated with increased plasma levels of IL-6 and decreased GMV in the left striatal structures. In addition, this study demonstrates that GMV loss in the left putamen is related to increased plasma levels of IL-6 in MDD with anhedonia, which provides further insights into the possible mechanisms of anhedonia.

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“…It is possible that anhedonia represents disruptions of mechanisms less in uenced by psychosocial factors such as family functioning. Previously, we documented that immune dysregulations and alterations in the reward circuitry predicted anhedonia severity (31,33,(66)(67)(68), suggesting anhedonia to be a clinical re ection of chronically dysfunctional biological processes (69). Altogether, further investigation is needed to better understand how depressive symptoms separately and combinedly contribute to adolescent perceptions of unhealthy family functioning.…”

Section: Anhedoniamentioning

confidence: 95%

“…Building and expanding upon the above observations, here we sought to examine the relationships between subconstructs of family dysfunction and symptomatology in a diverse sample of adolescents who presented predominantly with mood and anxiety symptoms. We speci cally assessed levels of anhedonia, depression, and anxiety as they often co-manifest clinically but likely represent distinct underlying mechanisms (25,(28)(29)(30)(31)(32)(33). We used the McMaster Family Assessment Device (FAD; (34)) to systemically evaluate family functioning by capturing seven complementary family domains.…”

Section: Introductionmentioning

confidence: 99%

Depression, Anxiety, and Anhedonia as Correlates of Distinct Family Functioning Domains among Adolescents

Nguyen,

Chance,

Chase

et al. 2023

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Background The bi-directional relationships between family dynamics and psychopathology have been documented, yet how aspects of family functioning relate to specific symptoms remains elusive. Such work is important in adolescence as it represents a vulnerable developmental period when psychiatric symptoms often emerge. Critically, most research on family functioning has focused on categorical clinical diagnoses and has not accounted for the inter-individual variability of symptom severity. Therefore, we aimed to study the associations between well-validated domains of family functioning and depression, anxiety, and anhedonia in youth using a dimensional approach. Methods We comprehensively evaluated 59 adolescents with diverse mood and anxiety symptoms and 17 controls with semi-structured diagnostic interviews and self-reported measures for depression, anxiety, and anticipatory and consummatory anhedonia. Adolescents’ perception of seven aspects of family life was assessed with the McMaster Family Assessment Device (FAD). Following bivariate assessments of associations between FAD subscales and symptom measures, linear regression models were employed to further investigate their relationships accounting for variations in age, sex, race, and ethnicity. Results were corrected for multiple comparisons. Results As hypothesized, more severe depression was implicated across most family domains, including Problem Solving, Communication, Roles, Affective Responsiveness, and General Functioning. Elevated anxiety was associated with worse family Problem Solving, Roles, and General Functioning. Interestingly, anhedonia showed no relationship with family domains following adjustment for multiple comparisons and depression severity, suggesting a different etiological pathway. Conclusions Our findings further support the intertwined relationships between family factors and adolescent mood processes and the need for specialized interventions addressing multiple family dimensions simultaneously.

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Clenbuterol attenuates immune reaction to lipopolysaccharide and its relationship to anhedonia in adolescents

Cited by 7 publications

References 100 publications

Gut microbiota-generated short-chain fatty acids are involved in para-chlorophenylalanine-induced cognitive disorders

Gut microbiota-generated short-chain fatty acids are involved in para-chlorophenylalanine-induced cognitive disorders

Increased plasma levels of IL-6 are associated with striatal structural atrophy in major depressive disorder patients with anhedonia

Depression, Anxiety, and Anhedonia as Correlates of Distinct Family Functioning Domains among Adolescents

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