Increased plasma levels of IL-6 are associated with striatal structural atrophy in major depressive disorder patients with anhedonia

Lu, Shengyong; Wu, Congchong; Jia, Lili; Fang, Zhe; Lu, Joan; Mou, Tingting; Hu, Shaohua; He, Hongjian; Huang, Manli; Xu, Yi

doi:10.3389/fpsyt.2022.1016735

Cited by 11 publications

(6 citation statements)

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“…The general exclusion criteria were as follows: (1) existence of any major medical disease, including cardiovascular, respiratory, endocrine and neurological diseases (e.g., epilepsy, brain trauma and stroke); (2) current use of any medication that might affect the central nervous system; (3) drug or alcohol dependence or abuse; (4) female with pregnancy; (5) with histories of psychotherapy and physical therapy, such as transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and electroconvulsive therapy (ECT); and (6) contraindications to MRI scan, including retractors or braces, metallic implants, and claustrophobia. The present study is one of our serial investigations focusing on MDD, and the recruitment of participants has been described in our previous studies [ 33 – 35 ]. This study was approved by the local Medical Ethics Committee of The First Affiliated Hospital, Zhejiang University School of Medicine.…”

Section: Methodsmentioning

confidence: 99%

“…Namely, “agree” or “strongly agree” was recorded as a score of 0, while “disagree” or “strongly disagree” was recorded as 1. The total score after conversion to > 5 could distinguish the presence or absence of severe anhedonia, which was used in some previous studies [ 35 , 39 ]. In this study, we defined severe anhedonia as a dichotomous variable with a SHAPS score > 5 and calculated the raw total scores of the SHAPS scale for MDD patients to assess the severity of anhedonia.…”

Section: Methodsmentioning

confidence: 99%

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Altered hippocampal subfield volumes in major depressive disorder with and without anhedonia

Wu,

Jia,

et al. 2023

BMC Psychiatry

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Background Previous neuroimaging findings have demonstrated the association between anhedonia and the hippocampus. However, few studies have focused on the structural changes in the hippocampus in major depressive disorder (MDD) patients with anhedonia. Meanwhile, considering that multiple and functionally specialized subfields of the hippocampus have their own signatures, the present study aimed to investigate the volumetric alterations of the hippocampus as well as its subfields in MDD patients with and without anhedonia. Methods A total of 113 subjects, including 30 MDD patients with anhedonia, 40 MDD patients without anhedonia, and 43 healthy controls (HCs), were recruited in the study. All participants underwent high-resolution brain magnetic resonance imaging (MRI) scans, and the automated hippocampal substructure module in FreeSurfer 6.0 was used to evaluate the volumes of hippocampal subfields. We compared the volumetric differences in hippocampal subfields among the three groups by analysis of variance (ANOVA, post hoc Bonferroni), and partial correlation was used to explore the association between hippocampal subregion volumes and clinical characteristics. Results ANOVA showed significant volumetric differences in the hippocampal subfields among the three groups in the left hippocampus head, mainly in the cornu ammonis (CA) 1, granule cell layer of the dentate gyrus (GC-ML-DG), and molecular layer (ML). Compared with HCs, both groups of MDD patients showed significantly smaller volumes in the whole left hippocampus head. Interestingly, further exploration revealed that only MDD patients with anhedonia had significantly reduced volumes in the left CA1, GC-ML-DG and ML when compared with HCs. No significant difference was found in the volumes of the hippocampal subfields between MDD patients without anhedonia and HCs, either the two groups of MDD patients. However, no association between hippocampal subfield volumes and clinical characteristics was found in either the subset of patients with anhedonia or in the patient group as a whole. Conclusions These preliminary findings suggest that MDD patients with anhedonia exhibit unique atrophy of the hippocampus and that subfield abnormalities in the left CA1 and DG might be associated with anhedonia in MDD.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Altered hippocampal subfield volumes in major depressive disorder with and without anhedonia

Wu,

Jia,

et al. 2023

BMC Psychiatry

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“…The general exclusion criteria for all subjects were as follows: (1) existence of any major medical disease including cardiovascular, respiratory, endocrine and neurological diseases (e.g., epilepsy, brain trauma, and stroke); (2) current use of any medication that might affect the central nervous system, (3) drug or alcohol dependence or abuse; (4) female with pregnancy; (5) with histories of psychotherapy and physical therapy, such as transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and electroconvulsive therapy (ECT); 6) contraindications to MRI scan, including retractors or braces, metallic implants, and claustrophobia. The present study is one of our serial investigations focusing on MDD and the recruitment of participants has been described in our previous studies [ 33 – 35 ]. This study was approved by the local Medical Ethics Committee of The First Affiliated Hospital, Zhejiang University School of Medicine.…”

Section: Methodsmentioning

confidence: 99%

Alterations of brainstem volume in patients with first-episode and recurrent major depressive disorder

Chen,

Jia,

Gao

et al. 2023

BMC Psychiatry

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Background Major depressive disorder (MDD) is a prevalent mental health condition characterized by recurrent episodes in a substantial proportion of patients. The number of previous episodes is one of the most crucial predictors of depression recurrence. However, the underlying neural mechanisms remain unclear. To date, there have been limited neuroimaging studies investigating morphological changes of the brainstem in patients with first-episode MDD (FMDD) and recurrent MDD (RMDD). This study aimed to examine volumetric changes of individual brainstem regions in relation to the number of previous episodes and disease duration. Method A total of 111 individuals including 36 FMDD, 25 RMDD, and 50 healthy controls (HCs) underwent T1-weighted structural magnetic resonance imaging scans. A Bayesian segmentation algorithm was used to analyze the volume of each brainstem region, including the medulla oblongata, pons, midbrain, and superior cerebellar peduncle (SCP), as well as the whole brainstem volume. Analyses of variance (ANOVA) were performed to obtain brain regions with significant differences among three groups and then post hoc tests were calculated for inter-group comparisons. Partial correlation analyses were further conducted to identify associations between regional volumes and clinical features. Results The ANOVA revealed significant brainstem volumetric differences among three groups in the pons, midbrain, SCP, and the whole brainstem (F = 3.996 ~ 5.886, adjusted p = 0.015 ~ 0.028). As compared with HCs, both groups of MDD patients showed decreased volumes in the pons as well as the entire brainstem (p = 0.002 ~ 0.034), however, only the FMDD group demonstrated a significantly reduced volume in the midbrain (p = 0.003). Specifically, the RMDD group exhibited significantly decreased SCP volume when comparing to both FMDD (p = 0.021) group and HCs (p = 0.008). Correlation analyses revealed that the SCP volumes were negatively associated with the number of depressive episodes (r=-0.36, p < 0.01) and illness duration (r=-0.28, p = 0.035) in patients with MDD. Conclusion The present findings provided evidence of decreased brainstem volume involving in the pathophysiology of MDD, particularly, volumetric reduction in the SCP might represent a neurobiological marker for RMDD. Further research is needed to confirm our observations and deepen our understanding of the neural mechanisms underlying depression recurrence.

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“…Boufidou et al demonstrated a relationship between the levels of IL-6 in the cerebrospinal fluid and symptoms of depression within the first 4 days after childbirth (p = 0.035) (39). Other authors reported elevated serum IL-6 levels in patients with anhedonia and a major depressive episode (40).…”

Section: Interleukins and Depressionmentioning

confidence: 98%

Depression, anxiety, insomnia and interleukins in the early postpartum period

Drozdowicz-Jastrzębska,

Mach,

Skalski

et al. 2023

Front. Psychiatry

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BackgroundSome new mothers have been shown to suffer from anxiety and depression associated with insomnia during the postpartum period. Our study assessed the impact of demographic, psychopathological, and biochemical factors on the incidence of depression in women during the early postpartum period.MethodsA total of 119 women were evaluated at 24–48 h postpartum with the following psychometric scales: Hamilton Depression Rating Scale (HDRS), Edinburgh Postnatal Depression Scale (EPDS), Hamilton Anxiety Rating Scale (HARS) and Athens Insomnia Scale (AIS). In addition, blood was drawn to assay interleukin 6 (IL-6) and interleukin 10 (IL-10).ResultsThe factors that had the greatest impact on the risk of postpartum depression detected with the HDRS were high HARS scores and evidence of insomnia in the AIS. There were no significant differences in IL-6 or IL-10 levels in women with and without depression (based on either HDRS or EPDS scores) and insomnia (based on AIS) after childbirth. Considering demographic factors, divorced and single women were shown to be at higher risk of postpartum depression (based on EPDS scores).LimitationsSmall sample size and short observation span.ConclusionThis study highlights the relationship between postpartum depression and both anxiety and insomnia and emphasises the importance to assess symptoms of anxiety and sleep quality as part of screening in women at risk of postpartum depression.

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Increased plasma levels of IL-6 are associated with striatal structural atrophy in major depressive disorder patients with anhedonia

Cited by 11 publications

References 66 publications

Altered hippocampal subfield volumes in major depressive disorder with and without anhedonia

Altered hippocampal subfield volumes in major depressive disorder with and without anhedonia

Alterations of brainstem volume in patients with first-episode and recurrent major depressive disorder

Depression, anxiety, insomnia and interleukins in the early postpartum period

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