Clearance of mucus by simulated cough

King, M.; Brock, Glenn A.; Lundell, C.

doi:10.1152/jappl.1985.58.6.1776

Cited by 191 publications

(125 citation statements)

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“…The in vitro representation of cough was performed using a simulated cough machine, (22) consisting of a simple airway model (a PVC tube), measuring 4 mm in internal diameter and 30 cm in length, within which the sputum samples were placed. This model was connected to a latex tube that linked it to a solenoid valve, which was connected to a timing system.…”

Section: Introductionmentioning

confidence: 99%

Influência da técnica de pressão expiratória positiva oscilante utilizando pressões expiratórias pré-determinadas na viscosidade e na transportabilidade do escarro em pacientes com bronquiectasia

Ramos

Iyomasa³

et al. 2009

J. bras. pneumol.

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OBJETIVO: Verificar a efetividade da técnica de pressão expiratória positiva oscilante (PEPO) utilizando pressões expiratórias pré-determinadas sobre a viscosidade e a transportabilidade do escarro em pacientes com bronquiectasia. MÉTODOS: Foram incluídos no estudo 15 pacientes estáveis com bronquiectasia (7 homens; média de idade = 53 ± 16 anos), submetidos a duas intervenções PEPO consecutivas, com 24 h de intervalo entre si, utilizando pressões expiratórias de 15 cmH2O (P15) e 25 cmH2O (P25). O protocolo consistiu de tosse voluntária; nova expectoração voluntária após 20 min, denominado tempo zero (T0); repouso de 10 min; e utilização da técnica em duas séries de 10 min (S1 e S2) de PEPO em P15 e P25, com intervalo de 10 min entre si. A viscosidade e transportabilidade do escarro foram avaliadas pela viscosimetria, velocidade relativa de transporte no palato de rã, deslocamento em máquina simuladora de tosse e ângulo de adesão. As amostras de escarro foram coletadas em T0, após S1 e após S2. Testes estatísticos específicos foram aplicados de acordo com a distribuição dos dados. RESULTADOS: Houve diminuição significante da viscosidade do escarro após S1 em P15 e após S2 em P25. Não houve diferenças significantes entre todas as amostras para a transportabilidade. CONCLUSÕES: Houve diminuição da viscosidade do escarro quando a PEPO foi realizada em P15 e P25, o que sugere que não seja necessário gerar alta pressão expiratória para obter o resultado desejado.

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Section: Introductionmentioning

confidence: 99%

Influência da técnica de pressão expiratória positiva oscilante utilizando pressões expiratórias pré-determinadas na viscosidade e na transportabilidade do escarro em pacientes com bronquiectasia

Ramos

Iyomasa³

et al. 2009

J. bras. pneumol.

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“…Analysis of the cough machine mucus transport was completed according to the model described by King et al 13 The model was composed of a pressure source (oxygen cylinder), a solenoid valve, and a simple scheme of airways, represented by a dry acrylic cylinder measuring 30 cm in length and 4 mm in internal diameter, with the 3 elements connected in a series. 14 When the cough simulator machine was activated, the timing device controlled the opening of the solenoid for one second, allowing the exit of air at 4.2 kgf/cm 2 of pressure, thus moving the secretion sample.…”

Section: Simulated Cough Machine Transportmentioning

confidence: 99%

The Influence of Purulence on Ciliary and Cough Transport in Bronchiectasis

et al. 2013

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BACKGROUND: Individuals with bronchiectasis exhibit colonization and infection of the respiratory system, with a consequent alteration of the macroscopic appearance of secretions, which ranges from mucoid to purulent. Purulence is related to the structural conformation, rheological profile, and transport indexes of mucus. We analyzed and compared the transport properties of respiratory secretions with mucoid appearance versus those with purulent appearance in patients with bronchiectasis and in subjects without lung disease. METHODS: In a simulated cough machine we assessed the mucociliary transport and contact angle of 32 mucoid and 19 purulent samples from subjects with bronchiectasis, and 21 samples from subjects without lung disease. RESULTS: Mucociliary transport was lower in the mucoid samples (0.78 ؎ 0.22) and in the purulent samples (0.73 ؎ 0.22) than in the samples from subjects without lung disease (1 ؎ 0.19). The purulent samples had less displacement in the simulated cough machine (7.57 ؎ 3 cm) than did the mucoid samples (23 ؎ 15 cm) or the samples from subjects without lung disease (34 ؎ 8.4 cm), as did the mucoid samples compared to the samples from subjects without lung disease. The purulent samples had a higher contact angle (25 ؎ 6.1°) than the mucoid samples (17 ؎ 7.8°) or the samples from subjects without lung disease (10 ؎ 2.5°), as did the mucoid samples compared to the samples from subjects without lung disease. CONCLUSIONS: Respiratory secretions in individuals with bronchiectasis have poor transport properties, which manifest as reduced mucociliary transport, reduced mucus transport by cough, and higher contact angle. These features were more accentuated in the purulent samples. This simple classification can be used by therapists to plan treatments, and by researchers to obtain more homogeneity between groups of subjects.

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“…The in vitro analysis of transportation by cough and sneeze uses an equipment called "cough simulator", adapted from King et al 29 . It is made up of a compressed air reservoir which predicts air flow and is controlled by a solenoid valve, followed by a resistance which provides the turbulent flow -similar to that of cough and sneeze 1 .…”

Section: Transportation By Cough and Sneezing -Cough And Sneezing Simmentioning

confidence: 99%

Métodos de estudo do transporte mucociliar

Trindade

Júnior

Mion

et al. 2007

Rev. Bras. Otorrinolaringol.

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Mucoci liary transport dysfunctions can impair the quality of life of patients suffering from chronic rhinossinusitis and lead to severe consequences such as alterations in respiratory physiology or even death as in cases of cystic fibrosis and primary ciliary dyskinesia. Therefore, it is crucial to understand the physiology of the mucociliary apparatus and how its components (cilia, mucus-periciliary layer and its interaction) affect the clearance of respiratory secretions. Aims: This paper aims to review and to discuss different techniques for studying mucociliary transport and their clinical and experimental applicability. Conclusions: The methods listed in this revision provide us with valuable information about different aspects of the mucociliary transport. Some of the methods listed are more suitable for clinical practice and present reproducible results. Others, show only applicability in experimental settings due to technical difficulties or financial limitations. However, it is important to emphasize that up to now there is no method that can evaluate ciliary beating frequency (CBF) in vivo and in situ. Such a method would become a valuable tool in the scientific scenario and in the clinical practice, supporting the diagnosis of ciliary dyskinesias and avoiding the use of invasive procedures to corroborate the clinical suspicion

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Clearance of mucus by simulated cough

Cited by 191 publications

References 0 publications

Influência da técnica de pressão expiratória positiva oscilante utilizando pressões expiratórias pré-determinadas na viscosidade e na transportabilidade do escarro em pacientes com bronquiectasia

Influência da técnica de pressão expiratória positiva oscilante utilizando pressões expiratórias pré-determinadas na viscosidade e na transportabilidade do escarro em pacientes com bronquiectasia

The Influence of Purulence on Ciliary and Cough Transport in Bronchiectasis

Métodos de estudo do transporte mucociliar

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