Clearance of Cervical Human Papillomavirus Infection by Topical Application of Curcumin and Curcumin Containing Polyherbal Cream: A Phase II Randomized Controlled Study

Basu, Partha; Dutta, Sankhadeep; Begum, Rakiba; Mittal, Srabani; Dutta, Paromita Das; Bharti, Alok C.; Panda, Chinmay Kumar; Biswas, Jaydip; Dey, Bindu; Talwar, G. P.; Das, Bhudev C.

doi:10.7314/apjcp.2013.14.10.5753

Cited by 66 publications

(61 citation statements)

References 15 publications

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“…Roy and Mukherjee (2014) recently demonstrated the reversal of resistance to cisplatin by adding curcumin in cisplatin resistance SiHa cervical cancer cell lines. Basu et al (2013) evaluated the positive therapeutic response of HPV infection in 289 HPV positive women with use of curcumin containing polyherbal vaginal cream as well as curcumin containing vaginal capsules for a period of 1 month. However they have not correlated response with cytokine levels.…”

Section: Interleukin-6mentioning

confidence: 99%

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

Paradkar¹,

Joshi²,

Mertia³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cytokine research is currently at the forefront in cancer research. Deciphering the functions of these multiple small molecules, discovered within the cell and in intercellular spaces, with their abundance and pleotrophism, was initially a great challenge. Advances in analytical chemistry and molecular biology have made it possible to unravel the pathophysiological functions of these polypeptides/proteins which are called interleukins, chemokines, monokines, lymphokines and growth factors. With more than 5 million women contracting cervical cancer every year this cancer is a major cause of mortality and morbidity the world over, particularly in the developing countries. In more than 95% of cases it is associated with human papilloma virus (HPV) infection which is persistent, particularly in those with a defective immune system. Although preventable, the mere magnitude of prevalence of HPV in the world population makes it a dominating current health hazard. The discovery of cytokine dysregulation in cervical cancer has spurted investigation into the possibility of using them as biomarkers in the early diagnosis of cases at high risk of developing cancer. Their critical role in carcinogenesis and progression of cervical cancer is now being revealed to a great extent. From diagnostics to prognosis, and now with a possible role in therapeutics and prevention of cervical cancer, the cytokines are being evaluated in all anticancer approaches. This review endeavours to capture the essence of the astonishing journey of cytokine research in cervical neoplasia.

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Section: Interleukin-6mentioning

confidence: 99%

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

Paradkar¹,

Joshi²,

Mertia³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Curcumin, a polyphenolic compound extracted from the rhizome part of the plant Curcuma longa is an Indian spice exhibiting chemopreventive properties (Biswas et al, 2010). Several preclinical and clinical studies indicated the anticancer potential of curcumin (Basu et al, 2013;Dai et al, 2013;Yin et al, 2013). Curcumin exhibited its antitumor action in HPV associated cervical cancer (Basu et al, 2013) by restoring p53 and pRb (Maher et al, 2011) and by reducing the level of cyclin D1 and activation of tumor suppressor proteins (Singh and Singh, 2011).…”

Section: Introductionmentioning

confidence: 99%

Reversal of Resistance towards Cisplatin by Curcumin in Cervical Cancer Cells

Roy¹,

Mukherjee²

2014

Asian Pacific Journal of Cancer Prevention

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Epigenetic regulators like histone deacetylases (1 and 2), and viral onco-proteins (E6/E7) are known to be overexpressed in cervical cancer cells. The present study was designed to investigate the effect of curcumin on HDACs (1 and 2) and HPV E6/E7 in the cervical cancer cell line SiHa and a drug resistant clone SiHa R (derived from SiHa). It was further intended to investigate whether curcumin could sensitize the cells towards cisplatin induced cell killing by modulation of multi drug resistant proteins like MRP1 and Pgp1. Curcumin inhibited HDACs, HPV expression and differentially increased acetylation and up-regulation of p53 in SiHa and SiHa R , leading to cell cycle arrest at G1-S phase. Up-regulation of pRb, p21, p27 and corresponding inhibition of cyclin D1 and CDK4 were observed. Cisplatin resistance in SiHa R due to over-expression of MRP1 and Pgp1 was overcome by curcumin. Curcumin also sensitized both the cervical cancer cells towards cisplatin induced cell killing. Inhibition of HDACs and HPVs led to cell cycle arrest at G1/S phase by alteration of cell cycle regulatory proteins. Suppression of MRP1 and Pgp1 by curcumin resulted in sensitization of cervical cancer cells, lowering the chemotherapeutic dose of the drug cisplatin.

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“…In a large study of 287 HPV-positive women, the efficacy of Basant polyherbal vaginal cream (containing extracts of curcumin, reetha, amla, and aloe vera) and of curcumin vaginal capsules to eliminate HPV infection from cervix were tested [24]. The women were randomized to four intervention arms to be treated with vaginal Basant cream, vaginal placebo cream, curcumin vaginal capsules, and placebo vaginal capsules, respectively.…”

Section: Vaginal Human Papillomavirusmentioning

confidence: 99%