An update on Curcuma as a functional food in the control of cancer and inflammation

Schaffer, Moshe; Schaffer, Pamela; Bar-Sela, Gil

doi:10.1097/mco.0000000000000227

Cited by 34 publications

(16 citation statements)

References 42 publications

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“…W., Booth, J., 2004;Daily, Yang, & Park, 2016;EMA, 2017;Ghalaut et al, 2012;Gupta et al, 2013;Khajehdehi et al, 2012;Kuptniratsaikul et al, 2014;Kuttan, Sudheeran, & Josph, 1987;Schaffer, Schaffer, & Bar-Sela, 2015). W., Booth, J., 2004;Daily, Yang, & Park, 2016;EMA, 2017;Ghalaut et al, 2012;Gupta et al, 2013;Khajehdehi et al, 2012;Kuptniratsaikul et al, 2014;Kuttan, Sudheeran, & Josph, 1987;Schaffer, Schaffer, & Bar-Sela, 2015).…”

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Toxicological safety evaluation of a novel highly bioavailable turmeric extract formulation

Phipps

Quesnot²,

Privat³

et al. 2019

J of Applied Toxicology

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Turmeric (Curcuma longa L.) extracts have a long history of use worldwide, but a major limitation of these extracts is their extremely low oral bioavailability, caused by low absorption, rapid metabolism and rapid excretion following ingestion. Thus, a new highly bioavailable turmeric extract formulation (comprising turmeric extract, acacia gum, sunflower oil and quillaia extract) has been developed and is intended for use as a food ingredient. Safety of this novel extract was evaluated using the standard Tier 1 battery of in vitro genotoxicity tests (bacterial reverse mutation test and an in vitro mammalian cell micronucleus test) followed by repeated‐dose 28‐ and 90‐day oral toxicity studies in rats. In the 90‐day study, male and female Sprague‐Dawley rats were dosed once daily, by oral gavage, either with the vehicle or the test item at 500, 1500 or 3000 mg/kg body weight/day. Clinical examinations were conducted regularly, and body weights and food consumption were recorded weekly throughout the study. At the end of the study, blood samples were analyzed for clinical pathology parameters, before a macroscopic necropsy was conducted and a full list of tissues were examined histopathologically. There was no evidence of genotoxicity in vitro. No test item‐related adverse effects were observed in the 28‐ or 90‐day studies; therefore, 3000 mg/kg body weight/day (the maximum feasible dose and highest dose tested in rats) was established as the no‐observed‐adverse‐effect level.

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“…R. W., Booth, J., 2004;Daily, Yang, & Park, 2016;EMA, 2017;Ghalaut et al, 2012;Gupta et al, 2013;Khajehdehi et al, 2012;Kuptniratsaikul et al, 2014;Kuttan, Sudheeran, & Josph, 1987;Schaffer, Schaffer, & Bar-Sela, 2015).…”

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confidence: 99%

Toxicological safety evaluation of a novel highly bioavailable turmeric extract formulation

Phipps

Quesnot²,

Privat³

et al. 2019

J of Applied Toxicology

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“…Free radicals usually attack several cell components, such as the polyunsaturated fatty acid (PUFA), deoxyribonucleic acid (DNA) and proteins (Schaffer et al, 2015). An increase in free radicals causes overproduction of Malondialdehyde (MDA), a final product of polyunsaturated fatty acids peroxidation in cells (Ewing et al, 2007).…”

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confidence: 99%

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Coneac

Orăsan

Leucuţa

et al. 2017

Not Bot Horti Agrobo

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Curcumin, a natural phenolic compound is an anti-tumor agent with anti-inflammatory and anti-oxidant properties. The aim of this research was to evaluate oxidative stress levels, the antioxidant activity and Curcumin concentrations by high performance liquid chromatography (HPLC) in an acute experimental inflammation induced by Turpentine oil (intramuscular 0.6 mg kg -1 body weight) and to compare a prophylactic versus a therapeutic regimen of Curcumin (oral suspension of 150 mg Curcumin kg -1 rat weight). Sixteen adult male Wistar rats were assigned to four groups: Control, Group I (Curcumin only), Group II (Curcumin administration, then induced inflammation after 1 hour) and Group III (induced inflammation then Curcumin administration after 2 hours). Oxidative stress was assessed by measuring serum malondialdehide and carbonylated proteins, while systemic and local total antioxidant capacity was determined by ABTS. Local tissue changes (muscle, kidney, liver) were analysed using histopathology. Results showed that acute inflammation significantly increased lipid peroxidation in Groups II and III compared to Control and Group I. A significantly reduced total antioxidant capacity (ATBS) was present in serum and kidney in Group II, also in muscle and kidney in Group III. ABTS levels were significantly increased only in the liver tissue of the animals in Groups II and III with induced inflammation as compared to Group I. This study proved the potential of Curcumin in reducing oxidative stress in both prophylactic and therapeutic regimens.

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“…Pharmacological studies of this herb resulted in reports on the antiinflammatory effects of the extract and sesquiterpenes were reported. [47][48][49][50] In our previous studies, we reported the hepatoprotective, vasodilative, and nitric oxide production-inhibitory activities of various sesquiterpenes and curcuminoids isolated from the rhizomes of C. zedoaria cultivated in China. [51][52][53][54][55][56] In our study, the 80% aqueous acetone extract of the dried rhizomes of C. zedoaria cultivated in Thailand (Thai zedoary) 57) was found to inhibit the release of β-hexosaminidase induced by the antigen in sensitized RBL-2H3 cells and ear PCA reactions in mice.…”

Section: Curcuminoidsmentioning

confidence: 99%

Degranulation Inhibitors from Medicinal Plants in Antigen-Stimulated Rat Basophilic Leukemia (RBL-2H3) Cells

2016

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Mast cells and basophils play important roles in both immediate-and late-phase reactions of type 1 allergy. Histamine, which is released from mast cells and basophils stimulated by an antigen or degranulation inducers, is usually determined as a degranulation marker in experiments on immediate allergic reactions in vitro. β-Hexosaminidase is also stored in secretory granules of the cells and is released concomitantly with histamine when the cells are immunologically activated, and recently this enzyme activity in the medium has been used as a marker of the degranulation. In this paper, we review our studies on the search for degranulation inhibitors, such as flavonoids, stilbenes, and curcuminoids, from medicinal plants using rat basophilic leukemia (RBL-2H3) cells.

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An update on Curcuma as a functional food in the control of cancer and inflammation

Abstract: The laboratory and the clinical studies until 2011 were summarized in a review published in this journal. An update of the new studies and knowledge from 2011 to March 2015 focuses on new ways to overcome its low bioavailability and data from clinical trials.

Cited by 34 publications

References 42 publications

Toxicological safety evaluation of a novel highly bioavailable turmeric extract formulation

Toxicological safety evaluation of a novel highly bioavailable turmeric extract formulation

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Degranulation Inhibitors from Medicinal Plants in Antigen-Stimulated Rat Basophilic Leukemia (RBL-2H3) Cells

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