Clearance Capacity of Rat Liver Kupffer, Endothelial, and Parenchymal Cells

Dalen, Danielle P. Praaning-Van; Brouwer, A.; Knook, D.L.

doi:10.1016/s0016-5085(81)80009-1

Cited by 172 publications

(49 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…22 KC represent the largest population of the body' s tissue macrophages localized in the sinusoidal space of the liver which have been implicated in the complex process of clearance and disposal of LPS from the portal blood. 23 The goal of the current study was to investigate the basal and the LPS-dependent gene expression of HBP23 in comparison to that of HO-1 in cultured KC of the rat.…”

Section: Heme-binding Protein 23 (Hbp23) Is a Cytosolic Protein That mentioning

confidence: 99%

Up-regulation of heme-binding protein 23 (HBP23) gene expression by lipopolysaccharide is mediated via a nitric oxide-dependent signaling pathway in rat Kupffer cells

et al. 1999

View full text Add to dashboard Cite

Section: Heme-binding Protein 23 (Hbp23) Is a Cytosolic Protein That mentioning

confidence: 99%

Up-regulation of heme-binding protein 23 (HBP23) gene expression by lipopolysaccharide is mediated via a nitric oxide-dependent signaling pathway in rat Kupffer cells

et al. 1999

View full text Add to dashboard Cite

“…The fatty change of the hepatocytes could result in a similar effect. It has recently been shown in animal experiments that not only Kupffer cells, but also parenchymal cells and endothelial cells of the liver take part in the clearance of antigens (14,15). However, as discussed below, the theory of excessive antigen stimuli as the cause of the increased humoral immune response in patients with liver disease has not been definitely proved.…”

Section: Discussionmentioning

confidence: 99%

Autoantibodies and Immunoglobulins in Alcoholic Steatosis and Cirrhosis

Gluud

Tage-Jensen

1983

Journal of Internal Medicine

View full text Add to dashboard Cite

ABSTRACT. Antinuclear antibodies were significantly more prevalent (p<0.01) in 143 patients with alcoholic cirrhosis than in 64 patients with alcoholic steatosis and in 94 controls. Smooth muscle antibodies were significantly more prevalent (p<0.05) in patients with alcoholic steatosis and cirrhosis than in controls. The prevalence of antimitochondrial antibodies and IgG liver membrane antibodies did not differ significantly between the three groups. Immunoglobulin G, A, and M concentrations were only occasionally increased in patients with steatosis. Patients with cirrhosis had significantly increased (p<0.005) concentrations of immunoglobulins G, A, and M when compared to patients with steatosis. These results indicate that the degree of liver damage has more effect than chronic alcoholism on the humoral immune system. Whether this influence is direct or indirect remains to be established.

show abstract

“…[19][20][21][22] In the normal animal a small amount of LPS may enter the portal circulation, however most is rapidly neutralised by circulating anti-LPS antibodies while the remainder is transported on specific proteins (LPSbinding protein) and cleared by the mononuclear phagocytic system of the liver. [23][24][25][26][27] LPS may enter the systemic circulation by one of several ways. Firstly, if the amount of LPS entering the portal circulation is large enough, the clearance capacity of the liver can be overwhelmed.…”

Section: General Pathophysiologymentioning

confidence: 99%

Equine endotoxaemia ‐ A state‐of‐the‐art review of therapy

2005

Aust Veterinary J

View full text Add to dashboard Cite

The pathophysiology of endotoxaemia, a leading cause of death in the horse, is beginning to be understood in greater detail. Endotoxin may be absorbed into the systemic circulation in a number of different ways: most commonly the body's normal defense mechanisms are disrupted or bypassed, or the normal clearance mechanisms overwhelmed. Following this wide-spread effects are observed, although the most significant are seen in the cardiovascular system. Fever, arterial hypoxaemia and signs of abdominal pain are also common. With increased understanding of the disease new therapeutic agents have become available, however, while the newer agents offer some advantages it is important to recognise that supportive care is the mainstay of treatment for endotoxaemia. Supportive care consists of aggressive fluid therapy (crystalloid, colloid and hypertonic), the administration of non-steroidal antiinflammatory drugs and, where appropriate, antimicrobials. The principles of supportive care are discussed in detail. Other therapies such as hyperimmune plasma, polymyxin B, pentoxifylline, dimethyl sulfoxide and heparin are commonly used in the treatment of equine endotoxaemia and their use is reviewed here. Furthermore, newer agents such as anti-tumour necrosis factor antibodies, detergent, activated protein C and insulin, which have yet to gain widespread acceptance but may have an important role in the treatment of endotoxaemia in the future, are examined.

show abstract

Clearance Capacity of Rat Liver Kupffer, Endothelial, and Parenchymal Cells

Cited by 172 publications

References 28 publications

Up-regulation of heme-binding protein 23 (HBP23) gene expression by lipopolysaccharide is mediated via a nitric oxide-dependent signaling pathway in rat Kupffer cells

Up-regulation of heme-binding protein 23 (HBP23) gene expression by lipopolysaccharide is mediated via a nitric oxide-dependent signaling pathway in rat Kupffer cells

Autoantibodies and Immunoglobulins in Alcoholic Steatosis and Cirrhosis

Equine endotoxaemia ‐ A state‐of‐the‐art review of therapy

Contact Info

Product

Resources

About