Autoantibodies and Immunoglobulins in Alcoholic Steatosis and Cirrhosis

Gluud, Christian; Tage-Jensen, U

doi:10.1111/j.0954-6820.1983.tb08571.x

Cited by 16 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum IgA levels tended to increase with alcohol consumption, being higher in heavy drinkers than in light‐to‐moderate drinkers and abstainers. It is known that serum IgA levels are higher in alcoholic cirrhosis than in non‐cirrhotic alcoholic liver disease [5,15–17], suggesting that alcoholic liver disease per se plays a role in IgA elevation. In fact, alcoholic liver disease has been defined as an IgA‐associated disorder [38].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities

Gonzalez-Quintela¹,

Alende²,

Gudé³

et al. 2007

Clinical and Experimental Immunology

536

412

View full text Add to dashboard Cite

SummaryThe present study investigated serum immunoglobulin (Ig) concentrations in relation to demographic factors, common habits (alcohol consumption and smoking) and metabolic abnormalities in an adult population-based survey including 460 individuals. Serum levels of interleukin (IL)-6, a marker of inflammation, were also determined. After adjusting for confounders, male sex was associated positively with IgA levels and negatively with IgM levels. Age was associated positively with IgA and IgG levels. Smoking was associated negatively with IgG levels. Heavy drinking was associated positively with IgA levels. Metabolic abnormalities (obesity and metabolic syndrome) were associated positively with IgA levels. Abdominal obesity and hypertriglyceridaemia were the components of metabolic syndrome associated most strongly with serum IgA. Heavy drinkers with metabolic syndrome showed particularly high serum IgA levels. Serum IL-6 levels were correlated positively with IgA and IgG concentrations. It is concluded that sex, age, alcohol consumption, smoking and common metabolic abnormalities should be taken into account when interpreting serum levels of IgA, IgG and IgM.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Also, serum immunoglobulin concentrations tend to increase with age [11,14]. It is well known that heavy drinkers with advanced liver disease often present with high IgA values [5,15–17], but fewer studies have addressed the effects of smoking and alcohol intake (from light to heavy) per se on serum IgA, IgG or IgM [18].…”

Section: Introductionmentioning

confidence: 99%

Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities

Gonzalez-Quintela¹,

Alende²,

Gudé³

et al. 2007

Clinical and Experimental Immunology

536

412

View full text Add to dashboard Cite

show abstract

“…Gluud et al in their study on patients with alcoholic cirrhosis have also shown occasionally increased levels of IgG, IgA, and IgM [6]. Gonzalez et al reported deranged IgG and IgM levels and statistically significant rise in IgA levels in alcoholics [8].…”

Section: Resultsmentioning

confidence: 91%

“…It has been documented in the past that chronic alcohol consumption may alter B cell numbers and causes hypergammaglobulinemia possibly due to antigenic stimulation of B lymphocytes [4]. However, except total IgE, conflicting results have been shown regarding individual immunoglobulins [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Immunoglobulins IgG, IgA, IgM and Total IgE in Chronic Alcoholics: A Community-based Study

Kumar¹

2015

Immunochem Immunopathol

View full text Add to dashboard Cite

Long-term intake of alcohol affects virtually every organ in the body including the immune system. The relation between alcohol abuse and immunoglobulin production has not been studied in Indian population. Serum levels of immunoglobulins (total IgE, IgG, IgM, and IgA) therefore, were analyzed in adult chronic alcoholics and were correlated with different epidemiological and alcohol-related parameters. The results showed that 98% of alcoholics had abnormal immunoglobulin levels and 92% showed high or very high total serum IgE levels compared to 24% of the control group. Long term and moderate consumption of alcohol were also associated with frequent infections. Serum immunoglobulin assay including total IgE may be helpful in screening and assessment of chronicity of alcohol abuse.

show abstract

“…Alternatively, liver disease in the fetus may induce autoimmunity in the mother. It is noteworthy that adults who have a variety of liver diseases may have a positive ANA (23)(24)(25). In some liver diseases, autoimmune processes are clearly involved and a positive ANA is not unexpected.…”

Section: Discussionmentioning

confidence: 99%

Autoantibodies in Mothers of Children with Neonatal Liver Disease

Burch,

Sokol,

Narkewicz

et al. 2003

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

ObjectivesNeonatal lupus erythematosus (NLE) is associated with maternal anti‐Ro/La autoantibodies. It is characterized by heart block and/or cutaneous skin lesions, and occasionally liver disease. This study was performed to determine whether idiopathic neonatal cholestasis (INC) represents NLE without its cardiac or cutaneous findings.MethodsSera were obtained for autoantibody analysis from mothers of children with INC (N = 11), biliary atresia (N = 25), other liver disease excluding viral hepatitis (liver disease control subjects, N = 14), and healthy children (normal control subjects [NC], N = 22).ResultsThe characteristic serologic findings of NLE, high titer antibodies to Ro and/or La, were absent in mothers from all groups. An unexpected finding was the prevalence of autoantibodies in mothers of infants with liver disease of any type. The frequency of maternal antinuclear antibodies at ≥ 1:120 dilution was greater than the estimated frequency in the general population (22% vs. 9%, P = 0.044). The frequency of maternal low titer autoantibodies to 52 kD Ro detected by ELISA was significantly greater than in the NC group (31% vs. 5%, P = 0.014).ConclusionsThe majority of cases of INC do not represent NLE. The frequent presence of autoantibodies in mothers of infants in all neonatal liver disease groups raises the possibility that maternal serologic autoimmunity is associated with neonatal liver disease.

show abstract

Autoantibodies and Immunoglobulins in Alcoholic Steatosis and Cirrhosis

Cited by 16 publications

References 18 publications

Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities

Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities

Evaluation of Serum Immunoglobulins IgG, IgA, IgM and Total IgE in Chronic Alcoholics: A Community-based Study

Autoantibodies in Mothers of Children with Neonatal Liver Disease

Contact Info

Product

Resources

About