Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities

Abstract

SummaryThe present study investigated serum immunoglobulin (Ig) concentrations in relation to demographic factors, common habits (alcohol consumption and smoking) and metabolic abnormalities in an adult population-based survey including 460 individuals. Serum levels of interleukin (IL)-6, a marker of inflammation, were also determined. After adjusting for confounders, male sex was associated positively with IgA levels and negatively with IgM levels. Age was associated positively with IgA and IgG levels. Smoking was associated negatively with IgG levels. Heavy drinking was associated positively with IgA levels. Metabolic abnormalities (obesity and metabolic syndrome) were associated positively with IgA levels. Abdominal obesity and hypertriglyceridaemia were the components of metabolic syndrome associated most strongly with serum IgA. Heavy drinkers with metabolic syndrome showed particularly high serum IgA levels. Serum IL-6 levels were correlated positively with IgA and IgG concentrations. It is concluded that sex, age, alcohol consumption, smoking and common metabolic abnormalities should be taken into account when interpreting serum levels of IgA, IgG and IgM.

Genome-wide association study identifies common variants at TNFRSF13B associated with IgG level in a healthy Chinese male population

“…31 Besides, the interactions between smoking and genetic effects on the IgG subclasses (IgG1, IgG2 and IG3) have been demonstrated in previous study. 7 Although in our two-stage GWA study, serum IgG level in smokers is significantly lower than that in non-smokers, which is consistent with previous studies; 7,9 there is no significant interaction between smoking and any of the three identified SNPs in determining the serum level of IgG. Nevertheless, the suggestion that the phenotype of TNFRSF13B mutations is affected by geneenvironment factors has been proposed by several studies.…”

“…6 Multitudinous environmental factors including infections, smoking and chemical compounds can contribute to this variation. [7][8][9] Reports of pedigree studies or twin studies 10,11 have shown that genetic factors are more important than environmental exposures in determining serum immunoglobulin level in human. 12,13 The values of genetic heritability was h 2 ¼ 0.617 þ 0.020 for IgG.…”

Determination of the Effect of the Elimination Diet Applied for Overweight and Obese People with Food Intolerance on Body Composition and Biochemical Parameters

“…Identification of food specific IgG has been emphasized as a significant factor in chronic inflammatory diseases, recently. IgG is also claimed to play a role in development of obesity [ 40,41 ]. In a previous study carried out to analyze the correlation between early aterosclerotic lesions in obese and normal-weight children, good antigens, C-reactive protein (CRP) and carotid artery intima media thickness (IMT) were measured and IgG antibodies were evaluated.…”

Plasma biomarkers of mouse aging

“…The significance of this is not clear. Interestingly, older people tend to have higher serum concentrations of immunoglobulins A and G (Gonzalez-Quintela et al 2008). It is possible that increased immunoglobulins indicate an increased inflammatory state at old age.…”