Clearance and elimination of 125I-Rose bengal in the sub-totally nephrectomized chronically uremic rat

The chronic uremic condition was induced in male Wistar rats by long term maintenance of the animals following sequential sub-total and contralateral nephrectomies. Hepatic reticuloendothelial (RES) activity was estimated by non-invasive measurement of blood clearance rates and hepatic uptake of 99Tcm sulfur colloid administered intravenously. The blood half-time, and the blood clearance rate constants for normals and chronic uremics were 78 +/- 10 s and 49.5 +/- 5 s, and 7.51 +/- 1.04 x 10(-3) s-1 and 10.81 +/- 1.17 x 10(-3) s-1 respectively. The normal hepatic uptake rate constant was 9.03 +/- 1.25 x 10(-3) s-1, compared with a uremic uptake rate constant of 14.34 +/- 1.51 s-1. Measurement of total liver radioactivity upon termination, 15 min after injection, showed significantly increased total uptake in uremia, whereas no change in spleen radioactivity was observed. The clinical implications of these data are discussed.

show abstract

Hepatic reticuloendothelial function in the sub-totally nephrectomized rat model of chronic uremia

Tse

Wiebe

Shysh

1979

Eur J Nucl Med

View full text Add to dashboard Cite

show abstract

Bone fluoride in chronically uremic rats

Wiebe

Shysh

Apps

et al. 1983

J. Radioanal. Chem.

View full text Add to dashboard Cite

The effect of acute renal failure on the pharmacokinetics of indocyanine green in the rat

Bowmer

Yats

Emmerson

1982

Biochemical Pharmacology

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Clearance and elimination of 125I-Rose bengal in the sub-totally nephrectomized chronically uremic rat

Cited by 17 publications

References 11 publications

Hepatic reticuloendothelial function in the sub-totally nephrectomized rat model of chronic uremia

Hepatic reticuloendothelial function in the sub-totally nephrectomized rat model of chronic uremia

Bone fluoride in chronically uremic rats

The effect of acute renal failure on the pharmacokinetics of indocyanine green in the rat

Contact Info

Product

Resources

About