The effect of acute renal failure on the pharmacokinetics of indocyanine green in the rat

Bowmer, C J; Yats, Michel S.; Emmerson, Jane

doi:10.1016/0006-2952(82)90065-x

Cited by 34 publications

(17 citation statements)

References 23 publications

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“…When 3 mg/ kg indocyanine green was infused into the inferior vena cava, the removal of indocyanine green resulted in a decrease in aortic blood concentrations in a pattern previously described (12) (Fig. 3).…”

Section: Portal Venous and Aortic Catheterized Rat 237supporting

confidence: 58%

“…Approximately 3 mg/kg body weight of indocyanine green was infused into the inferior vena cava and 0.15-ml blood samples were withdrawn at 0, 3, 6, 12, 18, 24, and 30 min after the bolus infusion. Indocyanine green concentrations in plasma was determined spectrophotometrically using a wave length of 800 nm (1 1 as described by Bowmer et al (12) All data are expressed as mean k SEM. The statistical significance of differences between samples was assessed using Student's t test with the Bonferroni corrections for multiple t test.…”

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confidence: 99%

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Portal Venous and Aortic Glucose and Lactate Changes in a Chronically Catheterized Rat

1988

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ABSTRACI'. A method for portal venous, aortic, and gastric cannulation in the rat is described. Changes in mean portal venous and aortic blood glucose and lactate concentrations after an intragastric infusion of d-glucose to chronically catheterized rats (after regaining preoperative weight) were compared to those of acutely catheterized rats (1 h after catheter placement). Both portal venous and aortic catheters were patent for blood sampling in 67% of rats 8 days after catheter placement and 42% after 14 days. After intragastric infusion of 10 ml of 0.29 M dextrose, mean aortic blood glucose and lactate concentrations in chronically catheterized rats increased 80 and 73%, respectively, 15 min after infusion and decreased to preinfusion concentrations by 60 min. In acutely catheterized rats, mean aortic glucose and lactate concentrations increased linearly for 60 min. The concentration differences between portal venous and aortic blood glucose and lactate concentrations in chronically catheterized rats were not significantly different than baseline differences. The portal venous glucose concentrations were significantly greater than aortic concentrations in acutely catheterized rats 15, 30, and 45 min after the glucose infusion when compared to baseline differences. These data suggest that the rate of glucose uptake and metabolism to lactate is significantly altered in acutely catheterized rats when compared to chronically catheterized animals. (Pediatr Res 23: 235-240,1988) Abbreviation AVC, area under the curve.(4); manual manipulation of the bowel can alter mesenteric blood flow and anesthesia can alter mesenteric blood flow and intestinal perfusion (5). These factors can alter intestinal perfusion and oxygen delivery. In contrast, studies that use the technique of chronic catheterization avoid these artifacts (6).We have developed a rat model in which the portal vein, aorta, and stomach are catheterized chronically. Using this preparation, we serially determined in vivo portal venous and aortic blood concentrations of glucose, lactate, and alanine after a bolus intragastric infusion of glucose in nonstressed animals. We also determined the effects of surgery and anesthesia on portal venous and aortic blood glucose, lactate, and alanine concentrations. MATERIALS AND METHODS Animals.All experiments were performed in vivo using adult male albino Sprague-Dawley rats (200-300 g body weight). These animals were obtained from Simonsen Labs (Gilroy, CA) and allowed free access to water and rat food.Catheters. The portal vein catheter consisted of two 1.5 cm segments of PE 60 tubing (Clay Adams, Parsippany, NJ; ID 0.76 mm, OD 1.22 mm) connected to the ends of a 4.5-cm silastic tube (Dow Corning, Midland, MI; silastic ID 0.64 mm, OD 1.19 mm). The silastic tubing was stretched securely over the segment of PE 60 tubing. The ends of the PE 60 tubing were cut to a sharp point at an angle of approximately 45". The catheter was then placed over an 8.89-cm 25-gauge spinal needle (Becton Dickinson, Rutherford, NJ) which s...

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Section: Portal Venous and Aortic Catheterized Rat 237supporting

confidence: 58%

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confidence: 99%

Portal Venous and Aortic Glucose and Lactate Changes in a Chronically Catheterized Rat

1988

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“…The method for the production of ARF has been described in detail (Bowmer et al, 1982). Male Wistar albino rats (220-330 g) were dehydrated for 24 h and ARF was produced by intramuscular injection of 50% v/v glycerol in sterile saline (0.9% w/v NaCI), 10ml kg-' body weight.…”

Section: Induction Ofacute Renalfailurementioning

confidence: 99%

Effect of the adenosine antagonist 8‐phenyltheophylline on glycerol‐induced acute renal failure in the rat

Bowmer¹,

Collis²,

Yates³

1986

British J Pharmacology

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8‐Phenyltheophylline (8‐PT) (10 mg kg−1) or its vehicle (1 ml kg−1) were administered intravenously or intraperitoneally twice daily over 48 h to rats with acute renal failure (ARF) induced by intramuscular (i.m.) injection of glycerol. Rats treated with 8‐PT i.v. had significantly lower plasma urea and creatinine levels at 24 and 48 h compared to untreated animals. The vehicle also reduced plasma urea and creatinine when compared to untreated controls. However, plasma urea levels in 8‐PT‐treated rats were significantly lower than in vehicle‐treated animals at 24 and 48 h after both i.v. and i.p. administration. Plasma creatinine concentrations also tended to be lower in the 8‐PT‐treated group. [3H]‐inulin clearance at 48 h after i.m. glycerol was significantly greater in rats dosed i.p. with 8‐PT compared to either untreated or vehicle treated rats. Examination of kidneys taken from rats 48 h after i.m. glycerol showed that 8‐PT treatment significantly reduced renal damage and kidney weight compared to the untreated or vehicle‐treated groups. In a 7 day study all the rats which received 8‐PT i.p. survived whilst in the vehicle and untreated groups the mortality rates were 12 and 21% respectively. In a separate series of experiments 8‐PT (10 mg kg−1; i.v. or i.p.) was found to antagonize adenosine‐induced bradycardia in conscious rats for up to 5 h. There is no clear explanation for the partial protection afforded by the vehicle but it may be related to either its alkalinity or an osmotic effect produced by the polyethylene glycol component. The protective effect of 8‐PT in rats with ARF was probably the result of adenosine antagonism.

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“…Ouabain and TChA were also chosen because they are not biotransformed in the rat (Cox et al, 1959;Hoffman et al, 1975). A preliminary account of some of this work has been given (Bowmer et al, 1982b;1983b).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and biliary excretion of bromosulphophthalein, [³H]‐ouabain and [³H]‐taurocholic acid in rats with glycerol‐induced acute renal failure

Bowmer

Yates

1984

British J Pharmacology

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1 The pharmacokinetics and biliary excretion of bromosulphophthalein (BSP), ouabain and taurocholic acid (TChA) have been studied in rats with glycerol-induced acute renal failure (ARF). 2 In rats with ARF, the hepatic uptake and initial biliary excretion of BSP were decreased. In addition, the rate of BSP conjugation with glutathione by rat liver homogenates was also decreased. This latter change may contribute to the initial decrease in the biliary excretion of BSP. 3 No change was found in the hepatic uptake and biliary excretion of ouabain, but the area under the concentration-time curve was increased and the plasma clearance (Clp) decreased in rats with ARF. This decrease in Clp was not due to reduced renal excretion. 4 The decreased Clp of ouabain in rats with ARF may come from reduced tissue binding and a concomitant decrease in its volume of distribution (Vd). 5The hepatic handling of TChA appeared unaltered in ARF, but the rate constant for the terminal part of the concentration-time curve (f) was decreased. This change probably resulted from a large increase in Vd in rats with ARF. 6 It is concluded that the decreased uptake of BSP was not due to a non-specific disturbance of hepatocyte function in ARF because the hepatic handling of ouabain and TChA were unaltered.

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The effect of acute renal failure on the pharmacokinetics of indocyanine green in the rat

Cited by 34 publications

References 23 publications

Portal Venous and Aortic Glucose and Lactate Changes in a Chronically Catheterized Rat

Portal Venous and Aortic Glucose and Lactate Changes in a Chronically Catheterized Rat

Effect of the adenosine antagonist 8‐phenyltheophylline on glycerol‐induced acute renal failure in the rat

Pharmacokinetics and biliary excretion of bromosulphophthalein, [³H]‐ouabain and [³H]‐taurocholic acid in rats with glycerol‐induced acute renal failure

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The effect of acute renal failure on the pharmacokinetics of indocyanine green in the rat

Cited by 34 publications

References 23 publications

Portal Venous and Aortic Glucose and Lactate Changes in a Chronically Catheterized Rat

Portal Venous and Aortic Glucose and Lactate Changes in a Chronically Catheterized Rat

Effect of the adenosine antagonist 8‐phenyltheophylline on glycerol‐induced acute renal failure in the rat

Pharmacokinetics and biliary excretion of bromosulphophthalein, [3H]‐ouabain and [3H]‐taurocholic acid in rats with glycerol‐induced acute renal failure

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Pharmacokinetics and biliary excretion of bromosulphophthalein, [³H]‐ouabain and [³H]‐taurocholic acid in rats with glycerol‐induced acute renal failure