Clear cell syringofibroadenoma (of Mascaro) of the nail

Fouilloux, B.; Perrin, Christophe; Dutoit, Martine; Cambazard, F.

doi:10.1046/j.1365-2133.2001.04099.x

Cited by 16 publications

(7 citation statements)

References 9 publications

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“…There is typically an intimately associated fibrovascular stroma and inflammatory infiltrate including prominent mast cells and plasma cells. Similar to CCA, ultrastructural analysis has revealed the presence of accumulated glycogen within keratinocytes, although a ‘clear cell’ variant of ESFA has been relatively rarely reported . Immunohistochemical analysis of ESFA has shown a pattern that most closely resembles the dermal portion of the eccrine duct .…”

Section: Discussionmentioning

confidence: 92%

Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?

Shalin

Rinaldi²,

Horn

2013

J Cutan Pathol

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We observed two patients with solitary lesions showing features of clear cell acanthoma with underlying eccrine syringofibroadenoma-like changes. The pathogenesis of these entities has been debated since their original descriptions, with most recent literature suggesting that both may represent reactive phenomena rather than true neoplasms. Our observation prompted us to perform a retrospective review of clear cell acanthoma cases to determine the frequency of such associated eccrine syringofibroadenoma changes. Of 47 examined cases of clear cell acanthoma, 9 (19%) showed associated changes of eccrine syringofibroadenoma. Immunohistochemical evaluation performed on a subset of cases identified similar but slightly divergent differentiation patterns within the lesions. While epithelial membrane antigen and PAS expression were similar in both components (although slightly different in intensity), the regions resembling eccrine syringofibroadenoma displayed additional immunoreactivities, supporting the presence of two distinct components. We have found that the concurrence of clear cell acanthoma with syringofibroadenomatous changes is more frequent than generally appreciated and suggest that these entities may share derivation from the eccrine apparatus.

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Section: Discussionmentioning

confidence: 92%

Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?

Shalin

Rinaldi²,

Horn

2013

J Cutan Pathol

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“…Spiradenomas can rarely be associated with Brooke-Spiegler syndrome, a rare autosomal dominant inherited disorder, characterised by the development of multiple skin adnexal tumours. 40 Microscopically, they involve a well-circumscribed nodular tumour in the dermis and subcutaneous tissue, Richly vascular stroma with occasional thrombi, foci of squamous differentiation, fibrosis and cystic degenerative changes are commonly seen. Apocrine differentiation has also been reported in spiradenomas, leading some authors to suggest that not all spiradenomas are of eccrine origin.…”

Section: Syringofibroadenoma (Acrosyringeal Adenomatosis)mentioning

confidence: 99%

Skin adnexal neoplasms—part 2: An approach to tumours of cutaneous sweat glands

2006

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Tumours of cutaneous sweat glands are uncommon, with a wide histological spectrum, complex classification and many different terms often used to describe the same tumour. Furthermore, many eccrine/apocrine lesions coexist within hamartomas or within lesions with composite/mixed differentiation. In addition to the eccrine and apocrine glands, two other skin sweat glands have recently been described: the apoeccrine and the mammary-like glands of the anogenital area. In this review (the second of two articles on skin adnexal neoplasms), common as well as important benign and malignant lesions of cutaneous sweat glands are described, and a summary for differentiating primary adnexal neoplasms from metastatic carcinoma is outlined, striving to maintain a common and acceptable terminology in this complex subject. Composite/mixed adnexal tumours are also discussed briefly.

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“…The secondary nail involvement that was seen has been rarely reported. [ 12 13 ] The lesion was subsequently excised by the general surgeon and there was no evidence of any recurrence during 1-year follow up. There are reports of carcinomatous transformation of ESFA; hence, every case should be followed in view of this risk of developing carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Solitary eccrine syringofibroadenoma with nail involvement: A rare entity

et al. 2015

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Eccrine syringofibroadenoma (ESFA) is a rare, benign tumor of eccrine sweat gland origin that usually presents as a nodule on the extremities of an elderly person. It can also present as an ulcerative plaque, verrucous lesion, papular or nodular lesion or as palmoplantar keratoderma. Although the clinical features are variable, histology is characteristic in the form of anastomosing strands, cords and columns of epithelial cells embedded in a fibrovascular stroma. We report the case of a 62-year-old male with a nodular lesion on the extremity that caused secondary involvement of the nail in the form of complete nail dystrophy. The histology showed features consistent with ESFA. Nail involvement by ESFA is a rare presentation and is rarely described in the literature.

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Clear cell syringofibroadenoma (of Mascaro) of the nail

Cited by 16 publications

References 9 publications

Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?

Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?

Skin adnexal neoplasms—part 2: An approach to tumours of cutaneous sweat glands

Solitary eccrine syringofibroadenoma with nail involvement: A rare entity

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