Clear Cell Papillary Renal Cell Carcinoma and Renal Angiomyoadenomatous Tumor

Deml, Karl-Friedrich; Schildhaus, Hans–Ulrich; Compérat, Éva; Teichman, Adriana von; Storz, Martina; Schraml, Peter; Bonventre, Joseph V.; Fend, Falko; Fleige, Barbara; Nerlich, Andreas G.; Gabbert, Helmut E.; GaBler, Nikolaus; Grobholz, Rainer; Hailemariam, Seife; Hinze, Raoul; Knüchel, Ruth; Lhermitte, Benoît; Nesi, Gabriella; Rüdiger, Thomas; Sauter, Guido; Moch, Holger

doi:10.1097/pas.0000000000000456

Cited by 62 publications

(24 citation statements)

References 51 publications

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“…It consists of variable papillary structures lined by cells with clear cytoplasm and low grade nuclei with a characteristic linear arrangement away from the basal aspect of cells (17). Despite its denomination, clear cell papillary RCC is genetically distinct from either conventional clear cell or papillary RCC (18,19). There is limited information regarding its clinical behaviour, especially for higher stage tumours, which have not been reported previously (20–22).…”

Section: Discussionmentioning

confidence: 99%

Histological subtype of renal cell carcinoma significantly affects survival in the era of partial nephrectomy

Nguyen

Vertosick

Corradi

et al. 2016

Urologic Oncology: Seminars and Original Investigations

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Summary Objectives To analyse whether the histological subtype of renal cell carcinoma (RCC) impacts survival post-surgical resection in contemporary patients, and if so, whether prognostic significance differs according to type of surgical resection or tumour stage. Materials and methods From 2006 to 2014, 2237 patients underwent surgical resection (25% radical nephrectomy [RN], 75% partial nephrectomy [PN]) for non-metastatic RCC at a tertiary referral centre. Estimated survival function curves and Cox regression models evaluated impact of histological subtype on recurrence-free survival (RFS) and overall survival (OS). Interaction analyses tested whether the impact of histological subtype depends on type of surgical resection or tumour stage. Results Patients with RCC stage T2 or lower, and those with low-grade conventional clear cell, papillary or chromophobe RCC of any stage had 5-yr RFS probabilities > 90%. Patients with clear cell papillary RCC stage T3 or greater had predicted 5-yr RFS of 81%. However, 5-yr OS probabilities were >94% for clear cell papillary RCC of any stage. High-grade conventional clear cell and papillary RCC stage T2 or lower, low-grade conventional clear cell and chromophobe RCC of any stage conferred 5-yr OS probabilities of > 93%. Unclassified RCC demonstrated the lowest OS probabilities at any stage. In multivariable analyses, histological subtype impacted RFS (p<0.0001) and OS (p=0.026) following surgical resection, with no differences in this association for RN versus PN (RFS p=0.2, OS p=0.4), and across pathologic stages (RFS p=0.1, OS p=0.3). Compared to low-grade conventional clear cell RCC, chromophobe (hazard ratio [HR] 0.72, 95% confidence interval [CI] 0.30, 1.75) and papillary RCC (HR 0.30, 95% CI 0.09, 0.97) conferred lower risk of recurrence. Chromophobe (HR 0.67, 95% CI 0.30, 1.52) and clear cell papillary RCC (HR 0.91, 95% CI 0.12, 6.78) conferred the lowest risk of all-cause mortality. Conclusions In the era of PN for RCC, histological subtype remained a significant predictor of survival, regardless of type of surgical resection or tumour stage.

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Section: Discussionmentioning

confidence: 99%

Histological subtype of renal cell carcinoma significantly affects survival in the era of partial nephrectomy

Nguyen

Vertosick

Corradi

et al. 2016

Urologic Oncology: Seminars and Original Investigations

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“…Punches were taken from tumor areas displaying >90% cancer cells which were marked previously on Hematoxylin and Eosin stained slides. DNA extraction from FFPE tissue was done as previously described [14,15,60]. The double-strand DNA (dsDNA) was quantified by the fluorescence-based Qubit dsDNA HS Assay Kit (Thermo Fisher Scientific, Inc., Waltham, MA, USA) according to manufacturer's instructions.…”

Section: Oncoscan Assaymentioning

confidence: 99%

Loss of CDKN1A mRNA and Protein Expression Are Independent Predictors of Poor Outcome in Chromophobe Renal Cell Carcinoma Patients

Ohashi

Angori

Batavia

et al. 2020

Cancers

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Chromophobe renal cell carcinoma (chRCC) patients have good prognosis. Only 5%–10% patients die of metastatic disease after tumorectomy, but tumor progression cannot be predicted by histopathological parameters alone. chRCC are characterized by losses of many chromosomes, whereas gene mutations are rare. In this study, we aim at identifying genes indicating chRCC progression. A bioinformatic approach was used to correlate chromosomal loss and mRNA expression from 15287 genes from The Cancer Genome Atlas (TCGA) database. All genes in TCGA chromophobe renal cancer dataset (KICH) for which a significant correlation between chromosomal loss and mRNA expression was shown, were identified and their associations with outcome was assessed. Genome-wide DNA copy-number alterations were analyzed by Affymetrix OncoScan® CNV FFPE Microarrays in a second cohort of Swiss chRCC. In both cohorts, tumors with loss of chromosomes 2, 6, 10, 13, 17 and 21 had signs of tumor progression. There were 4654 genes located on these chromosomes, and 13 of these genes had reduced mRNA levels, which was associated with poor outcome in chRCC. Decreased CDKN1A expression at mRNA (p = 0.02) and protein levels (p = 0.02) were associated with short overall survival and were independent predictors of prognosis (p < 0.01 and <0.05 respectively). CDKN1A expression status is a prognostic biomarker independent of tumor stage. CDKN1A immunohistochemistry may be used to identify chRCC patients at greater risk of disease progression.

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“… 1 CCTP-RCC has been recognized for its distinctive clinicopathologic and immunohistochemical features and its lack of molecular alterations, especially compared to other RCC subtypes. 2 , 3 We report a case of bilateral CCTP-RCC mimicking PKD.…”

Section: Introductionmentioning

confidence: 95%

Clear cell tubopapillary renal cell carcinoma mimicking polycystic kidney disease: A case report

Gomez

Althaus

Gruessner

et al. 2018

Urology Case Reports

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Clear cell tubopapillary renal cell carcinoma (CCTP-RCC) is a distinct histologic subtype of RCC recognized for its unique clinicopathologic and immunohistochemical features. A 72-year-old man with presumed polycystic kidney disease (PKD) and bilateral clear cell RCC (CC-RCC) underwent left radical nephrectomy and right partial nephrectomy 20 years ago at an outside hospital. On surveillance imaging, RCC recurrence was suspected and right radical nephrectomy was performed. Histologic and gross examination of the right remaining kidney was consistent with CCTP-RCC. Review of his original pathology report revealed both kidneys in fact represented CCTP-RCC, mimicking PKD.

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Clear Cell Papillary Renal Cell Carcinoma and Renal Angiomyoadenomatous Tumor

Cited by 62 publications

References 51 publications

Histological subtype of renal cell carcinoma significantly affects survival in the era of partial nephrectomy

Histological subtype of renal cell carcinoma significantly affects survival in the era of partial nephrectomy

Loss of CDKN1A mRNA and Protein Expression Are Independent Predictors of Poor Outcome in Chromophobe Renal Cell Carcinoma Patients

Clear cell tubopapillary renal cell carcinoma mimicking polycystic kidney disease: A case report

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