Clear cell tubopapillary renal cell carcinoma mimicking polycystic kidney disease: A case report

Abstract

Clear cell tubopapillary renal cell carcinoma (CCTP-RCC) is a distinct histologic subtype of RCC recognized for its unique clinicopathologic and immunohistochemical features. A 72-year-old man with presumed polycystic kidney disease (PKD) and bilateral clear cell RCC (CC-RCC) underwent left radical nephrectomy and right partial nephrectomy 20 years ago at an outside hospital. On surveillance imaging, RCC recurrence was suspected and right radical nephrectomy was performed. Histologic and gross examination of the right remaining kidney was consistent with CCTP-RCC. Review of his original pathology report revealed both kidneys in fact represented CCTP-RCC, mimicking PKD.

Vascular, adipose tissue, and/or calyceal invasion in clear cell tubulopapillary renal cell tumour: potentially problematic diagnostic scenarios

“…Seventy-eight percent (7/9) of the cases were radical nephrectomy specimens versus 22% (2/ 9) partial nephrectomy specimens, with near equal laterality. Most cases (8/9, 89%) consisted of a single dominant tumour (median size: 2.4 cm; range: 0.8 to 6.7 cm), with one case showing numerous clear cell tubulopapillary renal cell tumours (range: 0.1-3.7 cm) (this case has been previously reported 16 ). Of the 'pT3a' features, adipose tissue involvement predominated (eight cases; four into perinephric adipose tissue and four into hilar adipose tissue); the majority of which demonstrated 'bulging' extension into the adipose tissue (i.e.…”