Clear-Cell Meningioma in a 22-Month-Old Male

Carra, S; Drigo, Paola; Gardiman, Marina Paola; Perilongo, Giorgio; Rigobello, Luca

doi:10.1159/000056035

Cited by 38 publications

(9 citation statements)

References 14 publications

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“…Clear cell meningiomas exhibit a predilection for pediatric patients and typically arise in the lumbosacral spine. [3][4][5][6]8,9,11,12,18,21 The molecular underpinnings of CCM tumorigenesis and progression remain poorly defined. Recently, heterozygous loss-of-function mutations in the SWI/SNF chromatin remodeling complex subunit SMARCE1 were found in 4 individuals with familial multiple spinal meningiomas.…”

Section: Pediatricsmentioning

confidence: 99%

SMARCE1 mutations in pediatric clear cell meningioma: case report

Evans¹,

Hoff

Hickey

et al. 2015

PED

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Clear cell meningioma (CCM) is an uncommon variant of meningioma. The authors describe a case of a pediatric CCM localized to the lumbar spine. After resection, sequencing revealed an inactivating mutation in the SWI/SNF chromatin remodeling complex subunit SMARCE1, with loss of the second allele in the tumor. The authors present a literature review of this mutation that is associated with CCM and a family history of spine tumors.

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Section: Pediatricsmentioning

confidence: 99%

SMARCE1 mutations in pediatric clear cell meningioma: case report

Evans¹,

Hoff

Hickey

et al. 2015

PED

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“…have reported a case showing extension into the intervertebral foramen. [ 27 ] Our patient's MRI image showed anterior scalloping of the vertebral body and posterior thinning of the lamina with the intervertebral foramen extension. Dural tail sign, classically seen in the meningioma on imaging, was absent in our patient.…”

Section: Discussionmentioning

confidence: 84%

A giant nondural-based lumbosacral clear cell meningioma mimicking schwannoma: A case report and review of the literature

et al. 2021

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Spinal clear cell meningiomas (CCMs) are rare and dural-based lesion usually affecting the younger population. We report the rare case of giant nondural-based spinal CCM mimicking schwannoma and review the literature. A literature search was performed at PubMed and Embase until January 1, 2020. A total of 19 cases of nondural-based spinal CCM was reported. The following relevant data were extracted: authors, publication year, patient and tumor characteristics, treatment, and outcome. The mean age of the presentation was 20.58 years. Twelve (63.16%) were female and seven patients (36.84%) were male. The most common location was lumbosacral region 15 (79%). Fifteen (79%) tumors had cranio-caudal dimension ≤2 vertebral level, and only four (21%) tumors had dimension ≥2 vertebral level. Gross total resection (GTR) was performed in 18 (95%) patients and subtotal resection (STR) in 1 patient. Recurrences were reported in five (26.14%) patients. Four of them showed recurrences within 6 months; earliest at 2.3 months in the patient had undergone STR. Our patient is 19-year-old male diagnosed with a lumbosacral intradural lesion. Craniocaudal dimension is ≥2 vertebral level shows the foraminal extension and vertebral scalloping. GTR is performed. Intraoperatively, the tumor has foraminal extension and shows attachment with right S1S2 nerve root. No dural attachment is found. Six-month follow-up magnetic resonance image shows no evidence of disease. Nondural-based spinal CCMs are extremely rare and should be kept as a differential diagnosis in young patients with giant intradural tumor, and whose radiological features suggesting of schwannoma. It affects young patients and usually involves more than one vertebral level. The chances of recurrences and metastasis are always high even after GTR; hence, close follow-up of the entire neuraxis is warranted.

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“…Spinal meningiomas typically attach to the dura, and non-dural spinal meningiomas are rare 1 , 7 , 10 , 12) . Eighteen cases of non-dural based spinal meningiomas have been reported to date ( Table 1 ) 2 , 3 , 4 , 6 , 8 , 9 , 11 , 13 , 14 , 16 , 17 , 18 , 19 , 20 , 21 , 22) . Most tumors in these cases occur in the lumbo-sacral region (16 cases), including the thoraco-lumbar junction (two cases) 2 , 3 , 4 , 6 , 8 , 9 , 11 , 13 , 14 , 16 , 17 , 18 , 19 , 20 , 22) .…”

Section: Discussionmentioning

confidence: 99%

“…Most of histopathologic subtype of non-dural-based spinal meningiomas was clear cell meningioma (15 cases) 2 , 3 , 4 , 6 , 8 , 11 , 13 , 14 , 16 , 18 , 20 , 21 , 22) , whereas the remaining three cases were angiomatous, transitional, and meningotheliomatous meningiomas 9 , 17 , 19) . The clear cell meningiomas were quite predominant, as high as approximately 83.3%.…”

Section: Discussionmentioning

confidence: 99%

Non-Dural-Based Spinal Meningioma : The First Case Report of a Fibrous Subtype and a Review of the Literature

Lee

Moon

Kim

et al. 2014

J Korean Neurosurg Soc

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Spinal meningiomas typically adhere to the dura matter. Non-dural based spinal meningiomas are rare and most are clear cell meningiomas. We report here the first case of a fibrous meningioma with non-dural attachment. The patient was a 49-year-old female, who complained of numbness in the legs and a gait disturbance. Magnetic resonance imaging revealed a 1.7×1.4-cm mass in the C7-T1 intra-dural extramedullary space, showing peripheral gadolinium enhancement without a "dural tail sign". A complete microsurgical resection was performed. The mass was covered with a white membrane but was not adhered to the dura, and its appearance was consistent with a neurilemmoma. The histopathological diagnosis was fibrous-type meningioma. The recovery of the patient was uneventful. No surgical complications and no recurrence of the tumor had occurred at the 6-month follow-up.

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Clear-Cell Meningioma in a 22-Month-Old Male

Cited by 38 publications

References 14 publications

SMARCE1 mutations in pediatric clear cell meningioma: case report

SMARCE1 mutations in pediatric clear cell meningioma: case report

A giant nondural-based lumbosacral clear cell meningioma mimicking schwannoma: A case report and review of the literature

Non-Dural-Based Spinal Meningioma : The First Case Report of a Fibrous Subtype and a Review of the Literature

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