Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease

Kuo, Kang-Ling; Lo, Chi-Shou; Lee, Li‐Yu; Yang, Chih‐Hsun; Kuo, Tseng‐Tong

doi:10.1016/j.jaad.2016.07.032

Cited by 11 publications

(11 citation statements)

References 11 publications

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“…Histologisch findet man in der Biopsie typischerweise eine blockartige Akanthose mit leichter Parakeratose, Spongiose und perivaskulärem lymphohistiozytärem Infiltrat mitvereinzelten Eosinophilen im oberen Korium. Die Veränderungen können einem Klarzellakanthom der Mamille ähneln [28].…”

Section: Mamillenekzemunclassified

Pathologie der Mamillenregion

Streng

Gutjahr

Aulmann³

et al. 2020

Pathologe

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ZusammenfassungDer klassische M. Paget der Mamille ist histologisch charakterisiert durch eine intraepidermale Tumorinfiltration, die von einem intraduktalen oder invasiven Mammakarzinom ausgeht, immunhistologisch durch eine regelhafte Überexpression von HER2 und klinisch durch ekzemartige Veränderungen von Mamille und Areola. Zu den Varianten mit davon abweichenden histologischen, immunhistologischen und klinischen Erscheinungsformen gehören der isolierte M. Paget der Mamille, der anaplastische M. Paget, der M. Paget mit Invasion und der pigmentierte M. Paget der Mamille. Differenzialdiagnostisch ist der M. Paget der Mamille abzugrenzen gegenüber benignen Veränderungen, insbesondere der Toker-Zell-Hyperplasie, dem Mamillenekzem und seltenen Dermatosen.

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Section: Mamillenekzemunclassified

Pathologie der Mamillenregion

Streng

Gutjahr

Aulmann³

et al. 2020

Pathologe

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“…• Prognosis and treatment: Mild-to-moderate potency topical corticosteroids and topical tacrolimus are used for the treatment. • Differential diagnosis: Allergic contact dermatitis (Kim et al 2014), cracked nipple (Santos et al 2016), Paget's disease (Aguayo-Carreras et al 2017;Dubar et al 2017), erosive adenomatosis (Kumar and Thomas 2013), and clear cell acanthoma (Kuo et al 2019;Kim et al 1999). • Prognosis and treatment: Topical and systemic corticosteroids, topical calcineurin inhibitors, and punch skin graft are used for the treatment.…”

Section: Gynecomastiamentioning

confidence: 99%

“…lower legs. However, other sites as the face, scalp, scrotum, and nipple and multiple lesions are also described (Kuo et al 2019;Borda et al 2018). Characteristic lesion is an erythematous papule or nodule with peripheral scaling ( Fig.…”

Section: Cutaneous Larva Migrans (Creeping Eruption)mentioning

confidence: 99%

Cutaneous Disorders of the Breast

Ranawaka¹,

Madarasinghe²,

Kannangara³

et al. 2020

Atlas of Dermatology, Dermatopathology and Venereology

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“…Clinically, CCA manifests as a well-circumscribed, firm, elevated, dome-shaped papule or nodule with a brown or erythematous surface, measuring between 0.5 and 2.0 cm [2,6,7]. The red overlying surface of CCA can often appear crusted, exudative, and hemorrhagic upon minor trauma [2].…”

Section: Introductionmentioning

confidence: 99%

“…As indicated by its nomenclature, the histopathologic hallmark of CCA is the presence of a well-demarcated psoriasiform acanthotic lesion with abundant, large, pale (clear) epithelial cells, especially in the spinous cell layer [1-4, 12, 13]. These pale cells show high intracellular glycogen content, secondary to decreased or absent respiratory enzymes such as phosphorylase, cytochrome oxidase, and succinic dehydrogenase [2,3,6,7,9,14]. Neutrophilic exocytosis, parakeratotic microabscesses, and vasodilatation are usually seen [2,7,8,12,13,15,16].…”

Section: Introductionmentioning

confidence: 99%

Pale (Clear) Cell Acanthoma of the Palate

Argyris

Nelson

et al. 2019

Head and Neck Pathol

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Clear cell acanthoma (CCA), also known as pale cell acanthoma, represents a rare benign epidermal tumor with strong predilection for the lower extremities of middle-aged individuals and no frank gender preference. The etiology of CCA is poorly understood, although a localized psoriasiform reaction is favored. Herein, we report on the clinicopathologic and immunohistochemical features, and HPV status of an apparent example of oral CCA. A 58-year-old female presented with a well-circumscribed, asymptomatic, exophytic, sessile and erythematous nodule of the right hard palate, measuring 0.7 cm in greatest dimension. Microscopically, the lesion featured parakeratosis and acanthosis with neutrophilic microabscesses and broad elongated rete pegs. In areas, spinous epithelial cells exhibited pale or clear cytoplasm without nuclear pleomorphism, mitoses or cytologic atypia. The supporting connective tissue revealed mild chronic inflammation with few scattered neutrophils and numerous capillary vessels. PAS histochemical stain with and without diastase disclosed the presence of cytoplasmic glycogen in the pale cells. The majority of glycogen-rich epithelial cells stained strongly for EMA and were negative for D2-40. Ki-67 immunostaining was confined only to the basal cell layer of the epithelium. A diagnosis of CCA was rendered. The lesion was negative for human papillomavirus (HPV) infection, as assessed by HPV-DNA PCR using the MY09/11 primers for the L1 conserved region, thus HPV infection does not appear to contribute to the pathogenesis of oral CCA. In conclusion, we report an intraoral example of CCA in order to raise awareness about this entity. KeywordsClear cell acanthoma • Pale cell acanthoma • Glycogen-rich acanthoma • Oral cavity • Clear cell acanthosis • EMA • HPV-PCR * Prokopios P. Argyris

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Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease

Cited by 11 publications

References 11 publications

Pathologie der Mamillenregion

Pathologie der Mamillenregion

Cutaneous Disorders of the Breast

Pale (Clear) Cell Acanthoma of the Palate

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