Clean Synthesis and Antibacterial Activities of Spiro[pyrimido[4,5-b]quinoline-5,5'-pyrrolo[2,3-d]pyrimidine]-pentaones

Three‐component synthesis of spiro[indoline‐3,5′‐pyrimido[4,5‐b]quinoline]‐triones in water

“…Considering the important biological properties of spirooxindoles fused heterocycles, and as part of our program aimed at developing new selective and environmentally friendly methodologies for the preparation of heterocyclic compounds [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36], we report herein an efficient and clean synthesis of spiro[indoline-3,5 0 -pyrimido [4,5-b]quinoline]-triones 4 through a one-pot, threecomponent condensation reaction of isatins 1, 2,6-diaminopyrimidin-4(3H)-one 2, and cyclohexane-1,3-diones 3 in water (Scheme 1).…”

Synthesis of heterocyclic scaffolds through 6-aminouracil-involved multicomponent reactions

“…80 Some novel 5-arylamino-pyrrolo[2,3-d]pyrimidine derivatives 90 were synthesized via microwave-assisted three-component reaction of N,N-dimethyl-6-aminouracil 1, aryl glyoxal monohydrates 88 and aryl amines 80 (Scheme 33). 81 The proposed 83 The products were evaluated in vitro for their antibacterial activities. Similarly, another reaction was reported by Dabiri and coworkers 84 in reuxing EtOH for 5-7 h affording products with 70-81% yield.…”

Advances in the Synthesis of 5- and 6-Substituted Uracil Derivatives

“…The complex polyheterocyclic compounds 154 were obtained in very good yields (78-90%). 75 Although a mechanism could not be established with certainty, a possible route was proposed as depicted in Scheme 68.…”