Advances in the Synthesis of 5- and 6-Substituted Uracil Derivatives

Bardagi, Javier Ivan; Rossi, Roberto A.

doi:10.1080/00304940903378776

Cited by 19 publications

(10 citation statements)

References 75 publications

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“…We also showed that the N , N ‐phenobarbital‐derived hemiaminal undergoes an unprecedented 1,2‐aryl shift (see the Supporting Information). These results bode well for accessing a wide range of biologically active uracil derivatives 21…”

Section: Reduction Of Barbituric Acids Using Smi2[a]mentioning

confidence: 99%

Selective Reduction of Barbituric Acids Using SmI₂/H₂O: Synthesis, Reactivity, and Structural Analysis of Tetrahedral Adducts

et al. 2013

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Section: Reduction Of Barbituric Acids Using Smi2[a]mentioning

confidence: 99%

Selective Reduction of Barbituric Acids Using SmI₂/H₂O: Synthesis, Reactivity, and Structural Analysis of Tetrahedral Adducts

et al. 2013

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“…35,36 On the other hand, uracil derivatives exhibit antiviral and antitumor activities and show herbicidal, insecticidal and bactericidal properties. 37,38 This paper presents a new nanocarrier for the DOX delivery into cancer cells (p(MVCA-AlT), Scheme 2). The nanocarrier consists of three active components: DADS, viologen and thymine.…”

Section: Introductionmentioning

confidence: 99%

A glutathione responsive nanocarrier based on viologen resorcinarene cavitand and 1-allylthymine

et al. 2022

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“…Second, they are well recognized as integral components of a great number of pharmaceuticals mostly having antiviral and/or antitumoral activity as well as acting as antibacterial, antiparasitic, or vasodilator/antihypertensive compounds. Recently, istradefylline has been FDA approved for Parkinson’s disease in adults. − …”

Section: Introductionmentioning

confidence: 99%

1-Ethyluracil, a New Scaffold for Preparing Multicomponent Forms: Synthesis, Characterization, and Computational Studies

Roselló

Benito

Barceló‐Oliver

et al. 2021

Crystal Growth & Design

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In this work, we describe the successful preparation of a series of cocrystals of the modified nucleobase 1-ethyluracil with different coformers in a 1:1 or 2:1 (nucleobase:coformer) ratio including urea (URE) or some compounds containing carboxylic and hydroxyl groups such as L-malic acid (MAL), Ltartaric acid (TAR), 2-hydroxybenzoic acid (SAL), 4-hydroxybenzoic acid (4HB), and 2,4-dihydroxybenzoic acid (DHB). The influence of the hydroxyl substituent on the alkyl chain for 1•TAR and 1•SAL cocrystals or the phenyl ring for 1•SAL, 1•4HB, and 1• DHB multicomponent solids was studied. All of the compounds were characterized by powder X-ray diffraction, FT-IR, and thermal methods. Moreover, for those whose single-crystal structures could be determined, computational studies were also performed to investigate the factors that may affect the cocrystal formation, the recurrent motifs, and the energies associated with the H-bonding interactions using DFT calculations and a combination of the quantum theory of atoms in molecules (QTAIM) and the noncovalent interaction index (NCIplot) computational tools.

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Advances in the Synthesis of 5- and 6-Substituted Uracil Derivatives

Cited by 19 publications

References 75 publications

Selective Reduction of Barbituric Acids Using SmI₂/H₂O: Synthesis, Reactivity, and Structural Analysis of Tetrahedral Adducts

Selective Reduction of Barbituric Acids Using SmI₂/H₂O: Synthesis, Reactivity, and Structural Analysis of Tetrahedral Adducts

A glutathione responsive nanocarrier based on viologen resorcinarene cavitand and 1-allylthymine

1-Ethyluracil, a New Scaffold for Preparing Multicomponent Forms: Synthesis, Characterization, and Computational Studies

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Advances in the Synthesis of 5- and 6-Substituted Uracil Derivatives

Cited by 19 publications

References 75 publications

Selective Reduction of Barbituric Acids Using SmI2/H2O: Synthesis, Reactivity, and Structural Analysis of Tetrahedral Adducts

Selective Reduction of Barbituric Acids Using SmI2/H2O: Synthesis, Reactivity, and Structural Analysis of Tetrahedral Adducts

A glutathione responsive nanocarrier based on viologen resorcinarene cavitand and 1-allylthymine

1-Ethyluracil, a New Scaffold for Preparing Multicomponent Forms: Synthesis, Characterization, and Computational Studies

Contact Info

Product

Resources

About

Selective Reduction of Barbituric Acids Using SmI₂/H₂O: Synthesis, Reactivity, and Structural Analysis of Tetrahedral Adducts

Selective Reduction of Barbituric Acids Using SmI₂/H₂O: Synthesis, Reactivity, and Structural Analysis of Tetrahedral Adducts