Clay nanoparticles as pharmaceutical carriers in drug delivery systems

Dong, Jiani; Zhang, Cheng; Tan, Songwen; Zhu, Qubo

doi:10.1080/17425247.2021.1862792

Cited by 38 publications

(18 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although other clay subgroups have been widely studied for drug delivery applications, [24][25][26][27] the main emphasis of this review article is physicochemical features of Laponite, with a focus on synthetic Laponite clays as a potential therapeutic drug carrier. [28] We first introduce the background on clay materials, including synthetic Laponite, and describe the essential properties that render Laponite an attractive material for pharmaceutical applications.…”

Section: Introductionmentioning

confidence: 99%

Laponite‐Based Nanomaterials for Drug Delivery

Kiaee

Dimitrakakis

Sharifzadeh

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

Laponite is a clay-based material composed of synthetic disk-shaped crystalline nanoparticles with highly ionic, large surface area. These characteristics enable the intercalation and dissolution of biomolecules in Laponite-based drug delivery systems. Furthermore, Laponite's innate physicochemical properties and architecture enable the development of tunable pH-responsive drug delivery systems. Laponite's coagulation capacity and cation exchangeability determine its exchange capabilities, drug encapsulation efficiency, and release profile. These parameters are exploited to design highly controlled and efficacious drug delivery platforms for sustained drug release. In this review, they provide an overview of how to design efficient delivery of therapeutics by leveraging the properties and specific interactions of various Laponite-polymer composites and drug moieties.

show abstract

Section: Introductionmentioning

confidence: 99%

Laponite‐Based Nanomaterials for Drug Delivery

Kiaee

Dimitrakakis

Sharifzadeh

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…The modified nanoclay can load drugs through encapsulation, immobilization, ion exchange reaction, or electrostatic interaction. Drug molecules interact with nanoclay minerals, and the interactions are driven by hydrogen bonding, hydrophilic/hydrophobic interaction, and ion exchange 37 …”

Section: Discussionmentioning

confidence: 99%

Halloysite/cellulose derivatives‐based bionanocomposites for controlled naproxen delivery

Macedo

Olivato

Marini

et al. 2021

J of Applied Polymer Sci

View full text Add to dashboard Cite

Bionanocomposites are biocompatible, biodegradable, low‐toxicity materials inorganic/biopolymer‐based, carrying drugs for controlled delivery. The development of novel materials aiming to improve drug efficacy and reduce its toxicity is a continuous focus of the pharmaceutical industry. In this work, we report the development of an innovative controlled naproxen delivery system. The bionanocomposites are composed of naproxen‐loaded halloysite and ethylcellulose/hydroxypropylmethylcellulose blends produced by the spray drying technique. Chemical modification in the halloysite nanotubes was performed, aiming to improve the ionic interactions with the naproxen. The bionanocomposites drug‐load efficiency and interactions were characterized by physicochemical analysis. We also evaluated the naproxen release and its transport mechanism. Results show an efficient drug loading into halloysite, varying from 70% to 90%. Moreover, the naproxen release was delayed up to four times (compared with raw naproxen), that is, 48 h from nanotubes by Fickian diffusion, and sustained for 60 h from (bio)nanocomposites. The naproxen release from bionanocomposites occurred by several processes as diffusion, polymer swelling, and erosion. Furthermore, no drug was released at simulated gastric fluid, which may reduce the undesirable gastrointestinal effects. The developed bionanocomposites are potential for clinical applications for controlled drug delivery, as naproxen, a nonsteroidal anti‐inflammatory, commonly prescribes chronic disease treatment.

show abstract

“…A new nanocomposite based on the spinel ferrite ZnFe

and halloysite was developed by Jermy et al [ 211 ] to be used as pulmonary nanocarrier. Halloysite (Al

(OH)

·2H

O) is a natural mineral clay similar to kaolin [ 212 ] and zinc ferrite; it has several biomedical applications, including drug delivery [ 213 ]. The nanocomposite was functionalized with dexamethasone (DEX, used in the therapy of patients with COVID-19) and coated with PEG using a lyophilization technique.…”

Section: Nanomaterials For Covid-19 Prevention and Treatmentmentioning

confidence: 99%

Nanoscale Technologies in the Fight against COVID-19: From Innovative Nanomaterials to Computer-Aided Discovery of Potential Antiviral Plant-Derived Drugs

et al. 2022

View full text Add to dashboard Cite

The last few years have increasingly emphasized the need to develop new active antiviral products obtained from artificial synthesis processes using nanomaterials, but also derived from natural matrices. At the same time, advanced computational approaches have found themselves fundamental in the repurposing of active therapeutics or for reducing the very long developing phases of new drugs discovery, which represents a real limitation, especially in the case of pandemics. The first part of the review is focused on the most innovative nanomaterials promising both in the field of therapeutic agents, as well as measures to control virus spread (i.e., innovative antiviral textiles). The second part of the review aims to show how computer-aided technologies can allow us to identify, in a rapid and therefore constantly updated way, plant-derived molecules (i.e., those included in terpenoids) potentially able to efficiently interact with SARS-CoV-2 cell penetration pathways.

show abstract

Clay nanoparticles as pharmaceutical carriers in drug delivery systems

Cited by 38 publications

References 144 publications

Laponite‐Based Nanomaterials for Drug Delivery

Laponite‐Based Nanomaterials for Drug Delivery

Halloysite/cellulose derivatives‐based bionanocomposites for controlled naproxen delivery

Nanoscale Technologies in the Fight against COVID-19: From Innovative Nanomaterials to Computer-Aided Discovery of Potential Antiviral Plant-Derived Drugs

Contact Info

Product

Resources

About