Clastogenic effects of cis-diamminedichloroplatinum

Adler, I.‐D.; El-Tarras, Adel

doi:10.1016/0027-5107(89)90113-9

Cited by 27 publications

(1 citation statement)

References 28 publications

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“…This phenomenon implicates multitude of testicular cells such as sertoli cells, Leydig cells and peritubular cells [ 5 , 6 ]. Synthesis of nucleic acid in germ cells especially in spermatogonia is impeded by CP treatment on account of its alkylating abilities [ 7 – 9 ]. Damages induced with CP to Leydig cells resulted in inhibition of testosterone secretion [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats

et al. 2017

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BackgroundCisplatin (CP), an effective anticancer agent, carries the risk of impairing testicular function leading to infertility. The present study aimed at evaluating the protective effect of A. hydaspica ethyl acetate extract (AHE) against CP-induced oxidative stress and testicular injuries in rats.MethodsRats were divided into six groups (n = 6). Group I (control), group II (CP single dose on day 16). Group III received AHE for 21 days. Group IV (CP + AHE; post- treatment group). Group V (AHE + CP; pre-treatment group) and group VI (CP + Sily).ResultsCP treatment reduced serum testosterone (T), LH and FSH, decreased the activity level of antioxidant enzymes while increased the concentration of oxidative stress markers, i.e. thiobarbituric acid reactive substances (TBARS), H2O2 and nitric oxide (NO) along with corresponding DNA damages. Furthermore, CP induced adverse morphological changes in testis of rats including reduced epithelial height and tubular diameter, increased luminal diameter with impaired spermatogenesis. Pre and post-treatment with AHE reduced the side effects of CP in testis tissues through improvement in the reproductive hormonal secretions, enzymatic activities, histological and DNA damage parameters. Pretreatment seems to be more effective and equivalent to silymarin group in reversing the CP deleterious effects as compared to post-treatment.ConclusionThe results demonstrated that A. hydaspica treatment in CP-induced testicular toxicity augments the antioxidants defense mechanism, reverted the level of fertility hormones, suppressed the histomorphological alterations and DNA damages and thus provides the evidence that it may have a therapeutic role in free radical mediated diseases.

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Section: Introductionmentioning

confidence: 99%

Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats

et al. 2017

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Effects of selenium pretreatment on cisplatin-induced chromosome aberrations in Wistar rats

Antunes

Francescato

Darin

et al. 2000

Teratog. Carcinog. Mutagen.

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Selenium is an essential trace element and a potent anticancer agent. Extensive laboratory studies demonstrate that selenium is an effective chemopreventive agent in various sites in animals. The administration of selenium as a chemopreventive agent raises the question whether the antioxidant selenium, alone or in combination with other dietary antioxidants, could protect non-tumor cells from the clastogenic effect of cisplatin. Therefore, the present study was undertaken to investigate the modulatory effects of selenium, combined or not with vitamin C, on cisplatin-induced chromosomal aberrations in Wistar rat bone marrow cells. The animals were sacrificed 18, 24, or 72 h after cisplatin injection. The results obtained in Wistar rat bone marrow cells showed a slight nonsignificant reduction in the total number of chromosomal aberrations induced by cisplatin (5 mg/kg b.w.) observed in the animals that received a pretreatment with a single dose of selenium (2 mg/kg b.w.). The administration of two doses of selenium (1 mg/kg b.w.) also did not inhibit the chromosomal damage induced by cisplatin. In the present study, no protective response was obtained with either a single or double dose of selenium in rats treated with cisplatin. Furthermore, the combination between selenium+vitamin C was no more effective than vitamin C alone in the protection against damage caused by this antitumor drug. Further investigations, with other forms of selenium, are necessary to elucidate a possible protective role of selenium in clastogenicity induced by free radicals generated by antitumor drugs.

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Mutagenicity, Carcinogenicity, and Teratogenicity

Gebhart¹

2004

Elements and Their Compounds in the Environment

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Clastogenic effects of cis-diamminedichloroplatinum

Cited by 27 publications

References 28 publications

Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats

Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats

Effects of selenium pretreatment on cisplatin-induced chromosome aberrations in Wistar rats

Mutagenicity, Carcinogenicity, and Teratogenicity

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