Clastogenic and Anticlastogenic Effect of the Essential Oil from<i>Casearia sylvestris</i>Swart.

Sousa, Fabrício G.; Schneider, Naira Fernanda Zanchett; Mendes, Caroline Eliza; Moura, Neusa Fernandes de; Denardin, Rosiane Berenice Nicoloso; Matuo, Renata; Mantovani, Mário

doi:10.1080/10412905.2007.9699309

Cited by 18 publications

(15 citation statements)

References 7 publications

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“…Monoterpenes can also be identified, but not in significant amounts (Sousa et al 2007, Stefanello et al 2010. The potential of terpenes for the treatment of candidiasis has been reported previously (Dalleau et al 2008, Martínez et al 2014 In the present work it was observed that both pure essential oil and fraction 1-6 are rich in non-oxygenated and oxygenated sesquiterpenes.…”

Section: Discussionsupporting

confidence: 66%

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Antifungal activities of the essential oil and its fractions rich in sesquiterpenes from leaves of Casearia sylvestris Sw.

Pereira

Marquete

Domingos

et al. 2017

An. Acad. Bras. Ciênc.

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Casearia genus (Salicaceae) is found in sub-tropical and tropical regions of the world and comprises about 160-200 species. It is a medicinal plant used in South America, also known as "guaçatonga", "erva-detiú", "cafezinho-do-mato". In Brazil, there are about 48 species and 12 are registered in the State of Rio de Janeiro, including Casearia sylvestris Sw. There are many studies related to the chemical profile and cytotoxic activities of extracts from these plants, although few studies about the antifungal potential of the essential oil have been reported. In this work, we have studied the antifungal properties of the essential oil of C. sylvestris leaves, as well as of their fractions, against four yeasts (Saccharomyces cerevisae, Candida albicans, C. glabrata and C. krusei) for the first time. The chemical analysis of the essential oil revealed a very diversified (n = 21 compounds) volatile fraction composed mainly of non-oxygenated sesquiterpenes (72.1%). These sesquiterpenes included α-humulene (17.8%) and α-copaene (8.5%) and the oxygenated sesquiterpene spathulenol (11.8%) were also identified. Monoterpenes were not identified. The fractions are mainly composed of oxygenated sesquiterpenes, and the most active fraction is rich in the sesquiterpene 14-hydroxy -9-epi-β-caryophyllene. This fraction was the most effective in inhibiting the growth of three yeast strains.

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Section: Discussionsupporting

confidence: 66%

“…The essential oils of this genus are rich in monoterpenes and sesquiterpenes (Tininis et al 2006, Sousa et al 2007, Silva et al 2008, Pereira et al 2017, and some of the main compounds already identified are α-zingiberene, α-humulene, caryophyllene, and bicyclogermacrene (Esteves et al 2005, Bou et al 2013.…”

Section: Introductionmentioning

confidence: 99%

Antifungal activities of the essential oil and its fractions rich in sesquiterpenes from leaves of Casearia sylvestris Sw.

Pereira

Marquete

Domingos

et al. 2017

An. Acad. Bras. Ciênc.

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“…The main constituents were germacrene D (18.6%), E-caryophyllene (14.7%), δ-cadinene (6.2%), and α-cadinol (5.4%). The predominance of sesquiterpene hydrocarbons in the leaves essential oil of Casearia species has been previously observed (Stefanello et al, 2010;Silva et al, 2008;Sousa et al, 2007;Schneider et al 2006;Esteves et al, 2005;De Morais et al, 1997). In particular, E-caryophyllene was found in all samples as a main component (more than 10%).…”

Section: Resultsmentioning

confidence: 63%

“…The essential oils of Casearia spp analyzed to date are rich in sesquiterpenes (De Morais et al, 1997;Esteves et al, 2005;Schneider et al, 2006;Sousa et al, 2007;Silva et al, 2008;Stefanello et al, 2010) and one sample showed cytotoxic activity (Silva et al, 2008). Casearia lasiophylla Eichler, known as "guaçatunga-graúda" is a tree native from Brazil for which no chemical or pharmacological evaluation has previously been reported.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and cytotoxic activity of the essential oil from the leaves of Casearia lasiophylla

Salvador¹,

Carvalho²,

Wisniewski³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The essential oil obtained by hydrodistillation from fresh leaves of Casearia lasiophylla Eichler, Salicaceae, was analyzed by gas capillary (GC/FID and GC/MS). The cytotoxicity of the leaves essential oil was tested in vitro against U251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarianresistant), NCI-H460 (lung), PC03 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The yield of oil was 0.02%. Fifty two compounds were identified, representing 87.1% of the total of the oil. The main components were identified as germacrene D (18.6%), β-caryophyllene (14.7%), δ-cadinene (6.2%), and α-cadinol (5.4%). The oil exhibited antiproliferative activity against all cell lines (TGI<100 μg/mL), with exception of NCI-H460 cell line (TGI 191.31 μg/mL). The highest activity was observed against UACC-62 (TGI 7.30 μg/mL), and K562 (TGI 7.56 μg/mL) cell lines. The observed activity could be related to high content of germacrene D and β-caryophyllene, compounds known as cytotoxic.

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“…The Brazilian Agency of Medicines (Agência Nacional de Vigilância Sanitária -ANVISA) recognizes the importance of the species that was included in a positive list of medicinal plants for sale in pharmacies (Brasil 2010). Secondary metabolites isolated/identified from C. sylvestris include monoterpenes and sesquiterpenes (Sousa et al 2007), nor-isoprenoids (Santos 2008, Wang et al 2009a, triterpenes, lapachol, cafeic, chlorogenic and vanillic acids, flavonoids (Raslan et al 2002), neolignans (Wang et al 2010), ellagic and gallic acids derivatives (Silva et al 2008a, Silva et al 2008b. Additionally, phytochemical studies of Casearia species have revealed the presence of typical oxygenated tricyclic cis-clerodane diterpenes in which the tetrahydrofuran ring bears two acyloxy groups at C18 and C19 (Chen and Wiemer 1991, Guittet et al 1988, Kanokmedhakul et al 2005, Oberlies et al 2002.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of morpho-anatomical and chemical differences between varieties of the medicinal plant Casearia sylvestris Swartz

Claudino

Sacramento

Koch

et al. 2013

An. Acad. Bras. Ciênc.

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Casearia sylvestris Swartz (Salicaceae) has been used in traditional medicine and its leaf extracts have been exhibited important pharmacological activities. The species presents morphological, chemical and genetic variation. Two varieties are considered due external morphological differences: C. sylvestris var. sylvestris and var. lingua. There are difficulties in definition of these varieties. The objective of this work is to evaluate chemical and morpho-anatomical differences between C. sylvestris varieties that can be applied in their distinction for pharmaceutical or botanical purposes. Transverse and paradermic sections of leaves were prepared for morphoanatomical, histochemical and quantitative microscopy (stomatal and palisade index) analyses. Diterpene profiles of the specimens were obtained by HPLC-DAD and TLC. Morpho-anatomical analyses demonstrated significant differences between the varieties only in paradermic sections: var. sylvestris -polygonal epidermic cell walls and hypostomatic; var. lingua -rounded epidermic cell walls and amphistomatic. No differences were observed for stomatal index; palisade index was found 2.8 for var. lingua and 3.9 for var. sylvestris. Chromatographic analyses confirmed previous results demonstrating that diterpene profile in varieties differs, with predominance of these metabolites in var. sylvestris. In conclusion, this work indicates that chromatographic analysis besides morphoanatomical analysis can be applied in distinction of C. sylvestris varieties.

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Clastogenic and Anticlastogenic Effect of the Essential Oil fromCasearia sylvestrisSwart.

Cited by 18 publications

References 7 publications

Antifungal activities of the essential oil and its fractions rich in sesquiterpenes from leaves of Casearia sylvestris Sw.

Antifungal activities of the essential oil and its fractions rich in sesquiterpenes from leaves of Casearia sylvestris Sw.

Chemical composition and cytotoxic activity of the essential oil from the leaves of Casearia lasiophylla

Evaluation of morpho-anatomical and chemical differences between varieties of the medicinal plant Casearia sylvestris Swartz

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