Classifications in Brief: Kellgren-Lawrence Classification of Osteoarthritis

Kohn, Mark D.; Sassoon, Adam; Fernando, Navin

doi:10.1007/s11999-016-4732-4

Cited by 855 publications

(641 citation statements)

References 32 publications

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“…One hurdle of the current study was the inability to assess weight-bearing joint space narrowing, a key radiographic feature assessed clinically in human OA patients(25). Fixation of limbs prior to microCT scanning results in artificial shrinkage of the joint space, making this measurement invalid.…”

Section: Discussionmentioning

confidence: 99%

“…Key features of this grading scheme (Table 2) are radiographic assessments typically utilized in day-to-day evaluation of human OA, including presence and location of osteophytes, subchondral bone changes, and articular bone lysis(24). Features of the proposed grading system are similar to the Kellgren-Lawrence score, which is the most widely used classification for radiographic analysis of human OA in clinical practice and is commonly applied in research settings(25). In this human scheme, a score of 0 (no OA) to 4 (most severe OA) is assigned and is based on joint margin osteophytes, joint space narrowing, subchondral bone sclerosis, small cyst-like lesions in the subchondral bone, and altered shape of bone ends(25).…”

Section: Methodsmentioning

confidence: 99%

“…Features of the proposed grading system are similar to the Kellgren-Lawrence score, which is the most widely used classification for radiographic analysis of human OA in clinical practice and is commonly applied in research settings(25). In this human scheme, a score of 0 (no OA) to 4 (most severe OA) is assigned and is based on joint margin osteophytes, joint space narrowing, subchondral bone sclerosis, small cyst-like lesions in the subchondral bone, and altered shape of bone ends(25). Similar to the OARSI histologic score (described below), the microCT grading scheme scored whole knee joints in their entirety.…”

Section: Methodsmentioning

confidence: 99%

“…Two-dimensional (2D) radiographic images of OA patients are interpreted using a variety of clinical features, such as presence and location of osteophytes, subchondral bone changes, and articular bone lysis(15). Of note, 2D radiography is not often employed for animal work and, instead, microcomputed tomography (microCT) is utilized(16).…”

Section: Introductionmentioning

confidence: 99%

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Development of a microcomputed tomography scoring system to characterize disease progression in the Hartley guinea pig model of spontaneous osteoarthritis

Radakovich

Marolf

Shannon

et al. 2017

Connective Tissue Research

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Aim: There is potential discrepancy between human and laboratory animal studies of osteoarthritis (OA), as radiographic assessment is the hallmark of the former and histopathology the standard for the latter. This suggests a need to evaluate OA in animal models in a manner similar to that utilized in people. Our study aimed to develop a whole joint grading scheme for microcomputed tomography (microCT) images in Hartley guinea pigs, a strain that recapitulates joint changes highlighted in human spontaneous OA. Materials and Methods: Knees from animals aged 2, 3, 5, 9, and 15 months were evaluated via whole joint microCT and standard histologic scoring. Quantitative microCT parameters, such as bone volume/total volume were also collected. Results: Both whole joint microCT and histologic scores increased with advancing age and showed strong correlation (r = 0.89. P < 0.0001). Histologic scores, which focus on cartilage changes, increased progressively with age. Whole joint microCT scores, which characterize bony changes, followed a stepwise pattern: scores increased between 3 and 5 months of age, stayed consistent between 5 and 9 months, and worsened again between 9 and 15 months. Conclusions: This work provides data that advocates the use of a whole joint microCT scoring system in guinea pig studies of OA, as it provides important information regarding bony changes that occur at a different rate than articular cartilage changes. This grading scheme, in conjunction with histology and quantitative microCT measurements, may enhance the translational value of this animal model as it pertains to human work.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of a microcomputed tomography scoring system to characterize disease progression in the Hartley guinea pig model of spontaneous osteoarthritis

Radakovich

Marolf

Shannon

et al. 2017

Connective Tissue Research

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“…Se incluyeron a 50 pacientes de ambos sexos con edades entre 40 y 70 años y diagnóstico de osteoartrosis grado II (leve) o grado III (moderada), de acuerdo a la clasificación de Kellgren-Lawrence (27,28) ; con problemas de movimiento en articulaciones medibles ubicado en rodillas, codos y muñecas, que seguían tratamiento solamente con AINE vía oral y que voluntariamente hayan aceptado participar en el estudio y con consentimiento informado.…”

Section: Participantesunclassified

Efecto de Maytenus krukovii "Chuchuhuasi" en el tratamiento de osteoartrosis leve-moderada. Ensayo clínico aleatorizado doble-ciego, controlado con placebo.

Mendocilla-Risco¹,

Villar-López²,

Villar-Lopez³

et al. 2017

Rev. per. med. integr.

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21REV PERU MED INTEGRATIVA.2017;2(1):21-9. ResumenObjetivo. Evaluar la seguridad y eficacia de Maytenus krukovii "chuchuhuasi" a diferentes dosis, en pacientes con osteoartrosis leve-moderada. Materiales y métodos. Ensayo clínico aleatorizado, doble ciego. Se incluyeron a 50 pacientes con osteoartrosis leve-moderada (clasificación de KellgrenLawrence) por cuatro semanas; distribuidos aleatoriamente en tres grupos: I (40 mg/kg/día de M. Krukovii); II (80 mg/kg/día de M. Krukovii) y III (15 g/día de Daucus carota como placebo). Se determinó en sangre: alaninoaminotransferasa (ALT), fosfatasa alcalina (FA), depuración de creatinina, hematocrito, tiempo de protrombina, velocidad de sedimentación y recuento leucocitario. Se evaluó la función, dolor y recorrido articular mediante el test de WOMAC antes y después de la intervención. Resultados. En el grupo II se encontró una disminución estadísticamente significativa de los valores de ALT, tiempo de protrombina y velocidad de sedimentación. El tiempo de protrombina (p=0,012) y la velocidad de sedimentación entre el grupo II y el grupo placebo fueron diferentes (p=0,003). El dolor referido fue estadísticamente distinto entre ambos grupos de estudio en comparación con el placebo (p=0,001; diferencia de medias: 1,3±0,89 en ambos casos). En el caso de la capacidad funcional, solo se encontró diferencia significativa entre el grupo II y el placebo (p=0,001, diferencia de medias: 2,1±1,0). El recorrido articular de rodilla fue diferente entre el grupo I y el grupo III (p=0,004). Conclusión. El uso de M. krukovii "chuchuhuasi" a dosis de 40 y 80 mg/kg p.c. por día, mostró disminuir el dolor referido y mejorar la capacidad funcional en pacientes con diagnóstico de osteoartrosis leve a moderada. Palabras clave: Maytenus; Osteoartritis; Ensayo Clínico; Tolerancia a medicamentos (Fuente DeCS)Safety and efficacy of Maytenus krukovii "Chuchuhuasi" decoction in mild to moderate osteoarthritis. A 4-week randomized double-blind placebo-controlled clinical trial Abstract Objective.To evaluate security and efficacy of Maytenus krukovii "chuchuhuasi" in different doses in patients who had mild-moderate osteoarthritis. Materials and Methods. Randomized Clinical Trial. Fifty patients with mild-moderate osteoarthritis (Kellgren-Lawrence classification) were included in a 4-week follow-up. They were distributed in three groups: I (40mg/kg/day of M. Krukovii); II (80 mg/kg/day of M. Krukovii) y III (15 g/day of Daucus carota, which acted like placebo). Alanine aminotransferase (ALT), alkaline phosphatase, creatinine depuration, hematocrit, prothrombin time, velocity of sedimentation and leukocyte count (WBC) were measured. The articular function, pain and join path were evaluated using WOMAC questionnaire before and after intervention. Results. A significate diminution of ALT, prothrombin time and velocity of sedimentation values (before and after intervention) was found in group II. Prothrombin time (p=0.012) and velocity of sedimentation (p=0.003) were statically different between group II ...

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Diagnosis and Treatment of Hip and Knee Osteoarthritis

Katz

Arant

Loeser

2021

JAMA

914

760

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ong characterized as a wear-and-tear disorder, osteoarthritis (OA) is now understood to have a complex pathophysiology affecting multiple joints and joint structures, as captured by the Osteoarthritis Research Society International definition of OA: "The disease manifests first as a molecular derangement (abnormal joint tissue metabolism) followed by anatomic, and/or physiologic derangements (characterized by cartilage degradation, bone remodeling, osteophyte formation, joint inflammation and loss of normal joint function), that can culminate in illness." 1 Worldwide, an estimated more than 240 million persons have symptomatic, activity-limiting OA, including an estimated more than 32 million in the US. 2,3 The knee and hip are 2 commonly affected joints and are the focus of this Review. Nearly 30% of individuals older than 45 years have radiographic evidence of knee OA, about half of whom have knee symptoms. 4,5 The prevalence of symptomatic, radiographic hip OA is around 10%. 6,7 The lifetime risk of symptomatic knee OA is greater in obese persons (body mass index Ն30) than in nonobese persons (19.7% vs 10.9%). 8 Prior joint trauma, such as anterior cruciate ligament rupture and ankle fracture, increases risk, accounting for 12% of knee OA cases. 9 The prevalence of symptomatic, radiographic knee OA was 11.4% in women and 6.8% in men in one large cohort study 4 and 18.7% in women and 13.5% in men in another large cohort study. 5 Compared with men with OA, women have more severe radiographic findings and symptoms. 10 Older age and female sex are risk factors for hip OA as well as knee OA. In addition, congenital and acquired anatomic abnormalities (eg, hip dysplasia) are risk factors for hip OA. Regarding race, African American and White persons have similar prevalence of hip OA (accounting for race, sex, and body mass index), while African American individuals, especially women, have higher prevalence of knee OA. 5,7 Osteoarthritis leads to substantial cost and mortality. Fortythree percent of the 54 million individuals in the US living with IMPORTANCE Osteoarthritis (OA) is the most common joint disease, affecting an estimated more than 240 million people worldwide, including an estimated more than 32 million in the US. Osteoarthritis is the most frequent reason for activity limitation in adults. This Review focuses on hip and knee OA.OBSERVATIONS Osteoarthritis can involve almost any joint but typically affects the hands, knees, hips, and feet. It is characterized by pathologic changes in cartilage, bone, synovium, ligament, muscle, and periarticular fat, leading to joint dysfunction, pain, stiffness, functional limitation, and loss of valued activities, such as walking for exercise and dancing. Risk factors include age (33% of individuals older than 75 years have symptomatic and radiographic knee OA), female sex, obesity, genetics, and major joint injury. Persons with OA have more comorbidities and are more sedentary than those without OA. The reduced physical activity leads to a 20% higher age-adj...

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Classifications in Brief: Kellgren-Lawrence Classification of Osteoarthritis

Cited by 855 publications

References 32 publications

Development of a microcomputed tomography scoring system to characterize disease progression in the Hartley guinea pig model of spontaneous osteoarthritis

Development of a microcomputed tomography scoring system to characterize disease progression in the Hartley guinea pig model of spontaneous osteoarthritis

Efecto de Maytenus krukovii "Chuchuhuasi" en el tratamiento de osteoartrosis leve-moderada. Ensayo clínico aleatorizado doble-ciego, controlado con placebo.

Diagnosis and Treatment of Hip and Knee Osteoarthritis

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