Classification of thyroid follicular lesions based on nuclear texture features—Lesion size matters

Changes in nuclear morphology and chromatin texture of basal keratinocytes in melasma

“…Nuclear morphometry and chromatin texture changes have been identified in situations where genomic modifications occur, such as in field cancerization and carcinomas with different prognoses . In melasma, this could support preliminary investigations of genotype or epigenetic differences in keratinocytes from healthy and injured skin.…”

Follicular thyroid lesions: is there a discriminatory potential in the computerized nuclear analysis?

“…In the present study, secondary indicators contributed to the high percentages of correct classification in the CRT regression model. Other problems that could affect the results are the inclusion of high tumor subtype diversity and disregarding the factor tumor size, that is, not correcting nuclear parameters by size ( 1 , 7 , 11 ), which could limit the usefulness of the method to lesions of certain diameters ( 11 , 13 ). The present study assessed only follicular-patterned tumors.…”

“…However, specifically for follicular-patterned tumors, nuclear parameters that can correctly differentiate malignant from benign lesions have not yet been established. This could be partly due to the small number of samples analyzed in previous studies, to absence of normalization of the results by nuclear dimension and to the assessment of few nuclear parameters ( 1 , 11 , 13 ). Hence, the objective of this study was to evaluate the discriminatory diagnostic efficiency of computerized image analysis of cell nuclei in histological materials obtained from FA, FC and FVPC.…”

“…Computerized image analysis is an objective and highly reproducible tool in daily practice and has proven to be a promising resource for assessing thyroid lesions. More widely used for assessing histological material ( 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ), computerized image analysis enables the detection of very subtle nuclear changes ( 11 ), whose investigation could also provide data for cytological material analysis ( 11 , 12 , 13 ).…”

Quantitate nuclear images for clinical diagnosis

“…Nuclear texture features enable for example classification lesion sites (3) or differentiation between cell physiological activities and transcription levels. The authors found not only increased DNA ploidy as well as decreased chromatin heterogeneity in NOD versus healthy mice but also changes of both parameters with aging of the animals.…”