Classification of Non-Hodgkin’s Lymphomas

Lennert, K.

doi:10.1007/978-3-642-81092-3_3

Cited by 41 publications

(18 citation statements)

References 513 publications

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“…The Kiel classification of NHL [18] is essentially based on a comparison of com mon morphological and immunological features of normal and neoplastic cells [25,26] has not yet been es tablished or is hypothetical [ 13].…”

Section: Discussionmentioning

confidence: 99%

Dual Expression of T and B Cell Markers in Human B Cell Neoplasias

Herrmann¹,

Lochner²,

Enders³

et al. 1983

Acta Haematol

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Macrophage- and T-cell-depleted mononuclear cells from 36 patients with B cell lymphoma and 12 healthy individuals were investigated by indirect immunofluorescence with the monoclonal antibodies NEI-011 (7.2) and NEI-015 (10.2). The monoclonal antibody NEI-011 (7.2) recognized the la antigen and identified almost all B cells in the peripheral blood of healthy individuals. Furthermore, neoplastic B cells from all patients except those with plasma cell proliferation were found to react with this antibody. NEI-015 (10.2), a monoclonal antibody known to react with both T cells and B-CLL cells, did not react with normal circulating B cells. However, this antibody did identify neoplastic B cells except in cases of plasma cell proliferation and lymphoblastic lymphoma.

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Section: Discussionmentioning

confidence: 99%

Dual Expression of T and B Cell Markers in Human B Cell Neoplasias

Herrmann¹,

Lochner²,

Enders³

et al. 1983

Acta Haematol

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“…At least morphologically, subsets of lymphocytes exist in both ML,WDL and ML,PDL (Lennert, 1978;Levine and Dorfman, 1975;Pangalis et al, 1977;Rilke et al, 1978;Said et al, 1979) and some components have been thought to resemble the partially or fully transformed lymphocytes of germinal centers (Rilke et al, 1978;Said et al, 1979). On the basis of the morphometric data in this report, perhaps there is some validity to these observations.…”

Section: Discussionmentioning

confidence: 45%

“…Since the nucleus is the cell organelle that is the principal basis for subtyping NHL into categories with differing prognoses, the importance of quantitating nuclear features is self-evident. Lymphocyte nuclear profile size and shape can readily be assessed in histologic sections, and these are the parameters that are usually measured (Abbott et al, 1982;Crocker et al, l982,1983a,b;Dardick, 1984a;Donhuijsen et al, 1984;Tosi et al, 1983Tosi et al, , 1984van der Valk et al, 1982van der Valk et al, , 1983, since they are so central to current NHL classification schemes Collins, 1974,1979;Lennert, 1978). However, the appearance of nuclei in histologic sections is also influenced by the amount and distribution of condensed chromatin, a nuclear constituent that is best assessed at the ultrastructural level.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural morphometric image analysis applied to estimation of condensed chromatin in normal and neoplastic lymphocytes

Dardick¹,

Dardick²,

Jeans³

et al. 1985

J. Elec. Microsc. Tech.

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Currently, quantitative studies of malignant lymphoma are being performed in an attempt to improve the classification of non-Hodgkin's lymphoma (NHL) for diagnostic, prognostic, and therapeutic purposes. Morphometric image analysis is one method that can be employed in cases of NIIL to obtain objective data of nuclear parameters; condensed chromatin being a compartment of the nucleus best measured at the ultrastructural level. This report assesses similarities or differences in the amount, distribution, and arrangement of condensed chromatin in nuclear profiles of normal and neoplastic lymphocytes in human surgical biopsy specimens. Morphometric data derived from electron micrographs of lymphocytes in germinal centers of lymph nodes with reactive hyperplasia (three cases) and small cell types of NHL (two examples of malignant lymphoma, well differentiated lymphocytic type (ML,WDL) and three cases of malignant lymphoma, poorly differentiated lymphocytic type (ML, PDL)) are compared. Results indicate that the distribution of condensed chromatin, i.e., the size of aggregates, and their spatial placement within the nucleus varies more than the amount 030th n e a n area per profile or mean volume) of this nuclear parameter, and that this applies to normal as well as neoplastic lymphocytes. When a series of condensed chromatin parameters were statistically compared, no major differences could be detected between lymphocytes in normal tissues and those in ML,WDL and ML,PDL, but considerable differences were found in each of the nuclear morphotypes in the individual cases within the groups. This degree of variation in nuclear characteristics within normal tissues and the two lymphoma categories has not been previously recognized. Clearly, the technique of morphometric analysis, as applied to electron micrographs, can provide new and useful data that must be appreciated if classification schemes currently used in NHL are to improve _ * and reflect biologic considerations.

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“…The 840 cases of NHL were classified histologically, according to the three classifications: Rappaport, Kiel, and the WF. [2][3][4] Patients were staged according to the Ann Arbor system.I2 Clinical staging procedures used on presentation included history and complete physical examination, chest radiograph, complete blood counts, blood biochemistry, iliac crest trephine biopsy, and bone marrow aspirate. Lymphograms and/or computed axial tomography were done to detect abdominal disease.…”

Section: Methodsmentioning

confidence: 99%

Histologic subtypes and survival of Chinese patients with non-Hodgkin's lymphomas

Liang

Loke

et al. 1990

Cancer

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The histologic subtypes and survival of 840 Chinese patients with non-Hodgkin's lymphoma (NHL) were reviewed. All cases were classified according to the Rappaport and Kiel systems and the Working Formulation (WF). A low incidence of nodular/follicular lymphomas (12%) was observed. The most common histologic subtypes were diffuse histiocytic, diffuse centroblastic, and diffuse large cell lymphomas, according to Rappaport, Kiel, and the WF, respectively. A high proportion (24%) of the cases were unclassifiable, according to Kiel, because of the precise terms of the classification. The "favorable"-prognosis NHL, according to Rappaport, or the low-grade NHL, according to Kiel and the WF, had a more indolent clinical course. However, except for the nodular mixed (Rappaport) or follicular mixed (WF) lymphomas which appeared to behave like the more aggressive NHL, a plateau was not seen in the survival curves of our patients with other kinds of favorable-prognosis or low-grade NHL, indicating the lack of curative potential of these tumors. The lymphoplasmacytoid lymphoma, according to Kiel, also appeared to have a more aggressive clinical course. A plateau was seen in most of the other survival curves of patients with the more aggressive tumors, indicating the prospect of cure. However, the prognosis of the very aggressive tumors such as the diffuse lymphoblastic and diffuse small noncleaved cell lymphomas, according to the WF, remains very poor with a median survival of less than 10 months.

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Classification of Non-Hodgkin’s Lymphomas

Cited by 41 publications

References 513 publications

Dual Expression of T and B Cell Markers in Human B Cell Neoplasias

Dual Expression of T and B Cell Markers in Human B Cell Neoplasias

Ultrastructural morphometric image analysis applied to estimation of condensed chromatin in normal and neoplastic lymphocytes

Histologic subtypes and survival of Chinese patients with non-Hodgkin's lymphomas

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