Classification of cutaneous squamous cell carcinoma

tion, degree of keratinization, location, and immunosuppression. The determination of whether desmoplasia, previously described in only one case of SCC, consti-1 Dermatological Clinic, University of Tübingen tutes an additional prognostic factor was the objective of this study. School of Medicine, Tübingen, Germany. METHODS.The study was performed prospectively on 594 SCCs from 509 patients. Institute of Pathology, University of TübingenAll of the factors mentioned earlier were present. Forty-four SCCs were identified School of Medicine, Tübingen, Germany.by light microscopy as desmoplastic due to their prominent trabecular growth patterns, narrow columns of atypical epithelial cells, and marked desmoplastic stromal reaction, in some cases with perineural and perivascular invasion. Followup ranged from 4 to 10 years (median, 5.3 years). RESULTS.All tumors in the study patient population were treated using the paraffin section method of micrographic surgery. The 44 desmoplastic SCCs were found to metastasize 6 times more often than the remaining 550 tumors (22.7% vs. 3.8%), with 10 times as many local recurrences (27.3% vs. 2.6%). CONCLUSIONS.Desmoplasia is a highly significant (P õ 0.001) prognostic factor for SCCs and is associated with the development of metastases or recurrence.

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Desmoplastic squamous cell carcinoma of skin and vermilion surface

Breuninger

Schaumburg-Lever

Holzschuh

et al. 1997

Cancer

221

182

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Dermatopathology

Thomas¹,

Aung²,

Rapini³

2021

Frozen Section Pathology

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Aktinische Keratose, Morbus Bowen, Keratoakanthom und Plattenepithelkarzinom der Haut

Majores¹,

Bierhoff²

2015

Pathologe

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Actinic (solar) keratosis is an intraepidermal squamous neoplasm of sun-damaged skin and by far the most frequent neoplastic skin lesion. A subdivison into three grades has been proposed with increasing acceptance not least because of the therapeutic consequences. The transition to invasive squamous cell carcinoma is reported in 5-10 % and with immunosuppression in 30 % of patients.Bowen's disease is a variant of squamous cell carcinoma in situ of the skin and the mucocutaneous junction. The differentiation from bowenoid papulosis as a lesion associated with human papillomavirus (HPV), actinic (solar) keratosis grade III, intraepidermal poroid lesions and in cases of clonal type from clonal seborrhoic keratosis and Paget's disease is very important.Keratoacanthoma is currently uniformly interpreted as a variant of highly differentiated squamous cell carcinoma of the skin with clinical and histomorphological characteristics. Clinically keratoacanthoma erupts rapidly and is capable of resolving spontaneously. Histologically, there is a characteristic growth pattern and various stages of regression. The final histomorphological diagnosis needs the entire specimen.Squamous cell carcinoma of the skin is the second most common type of skin cancer following basal cell carcinoma. With respect to reccurrencies and risk of metastases the subtyping of cutaneous squamous cell carcinoma is very important. The classification system of the Union Internationale Contra le Cancer (UICC) is based solely on the anatomical spread and the classification system of the American Joint Committee on Cancer (AJCC) also considers so-called high-risk features in the staging between stages I and II.

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Classification of cutaneous squamous cell carcinoma

Cited by 11 publications

References 14 publications

Desmoplastic squamous cell carcinoma of skin and vermilion surface

Desmoplastic squamous cell carcinoma of skin and vermilion surface

Dermatopathology

Aktinische Keratose, Morbus Bowen, Keratoakanthom und Plattenepithelkarzinom der Haut

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