Classification Criteria for Sarcoidosis-Associated Uveitis

Jabs, Douglas A.; Acharya, Nisha R.; Denniston, Alastair K.O.; Lightman, Susan; McCluskey, Peter; Oden, Neal; Okada, Annabelle A.; Palestine, Alan G.; Thorne, Jennifer E.; Trusko, Brett; Vitale, Albert T.

doi:10.1016/j.ajo.2021.03.047

Cited by 47 publications

(19 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although complications are very frequent, OS is usually associated with a favorable outcome and a permanent visual impairment is quite rare [ 9 ].…”

Section: Literature Reviewmentioning

confidence: 99%

“…A study including 83 patients reported a full recovery of vision in 60% of cases and none developed blindness. Sometimes, severe visual impairment (BCVA inferior to 0.1 in at least one eye) occurs in 2–10% of sarcoid uveitic patients [ 5 , 9 , 22 , 94 ]. Uni- or bi-laterality, chronicity and severity affect the visual prognosis of subjects suffering from OS.…”

Section: Literature Reviewmentioning

confidence: 99%

“…These criteria were then updated and published in 2019 [ 7 ]. Furthermore, the SUN recently published other criteria [ 9 ].…”

Section: Literature Reviewmentioning

confidence: 99%

“…Pulmonary diagnostics (chest X-ray, high resolution computed tomography (HRCT), bronchoalveolar lavage (BAL), 67 gallium scintigraphy, 18 FluoroDeoxyGlucose Positron Emission Tomography ( 18 F-FDG-PET), mediastinal biopsy), central nervous system (CNS) investigations, namely, encephalic magnetic resonance imaging (MRI), and dermatological counseling can help make a correct diagnosis [ 9 ]. Concerning serological work-up, high levels of angiotensin converting enzyme (ACE), lysozyme, and ß-2 microglobulin define an active disease.…”

Section: Introductionmentioning

confidence: 99%

“…Increased production of vitamin D from epithelioid cells causes hypercalciuria and, less frequently, hypercalcemia [ 9 , 10 , 11 , 12 , 13 , 14 ]. Cameli and colleagues studied a population of S patients and compared them to subjects suffering from idiopathic pulmonary fibrosis (IPF) and chronic hypersensitivity pneumonitis (cHP).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Sarcoid Uveitis: An Intriguing Challenger

Allegri¹,

Olivari²,

Rissotto

et al. 2022

Medicina

View full text Add to dashboard Cite

The purpose of our work is to describe the actual knowledge concerning etiopathogenesis, clinical manifestations, diagnostic procedures, complications and therapy of ocular sarcoidosis (OS). The study is based on a recent literature review and on the experience of our tertiary referral center. Data were retrospectively analyzed from the electronic medical records of 235 patients (461 eyes) suffering from a biopsy-proven ocular sarcoidosis. Middle-aged females presenting bilateral ocular involvement are mainly affected; eye involvement at onset is present in one-third of subjects. Uveitis subtype presentation ranges widely among different studies: panuveitis and multiple chorioretinal granulomas, retinal segmental vasculitis, intermediate uveitis and vitreitis, anterior uveitis with granulomatous mutton-fat keratic precipitates, iris nodules, and synechiae are the main ocular features. The most important complications are cataract, glaucoma, cystoid macular edema (CME), and epiretinal membrane. Therapy is based on the disease localization and the severity of systemic or ocular involvement. Local, intravitreal, or systemic steroids are the mainstay of treatment; refractory or partially responsive disease has to be treated with conventional and biologic immunosuppressants. In conclusion, we summarize the current knowledge and assessment of ophthalmological inflammatory manifestations (mainly uveitis) of OS, which permit an early diagnostic assay and a prompt treatment.

show abstract

“…Although complications are very frequent, OS is usually associated with a favorable outcome and a permanent visual impairment is quite rare [ 9 ].…”

Section: Literature Reviewmentioning

confidence: 99%