Classification and Pathology

Wu, Julie M.; Montgomery, Elizabeth A.

doi:10.1016/j.suc.2008.03.007

Cited by 36 publications

(26 citation statements)

References 161 publications

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“…34 Although labeling for S100 protein shows some nonspecific activity, it is the most commonly used marker to identify peripheral nerve sheath tumors (PNST) of various types. 6,42 In this study, S100 was identified in all DFTD tumor samples. The intensity of labeling and fraction of immunoreactive cells varied considerably among samples, which has been a common finding in other studies.…”

Section: Discussionmentioning

confidence: 62%

Tumor-Specific Diagnostic Marker for Transmissible Facial Tumors of Tasmanian Devils

et al. 2011

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Devil facial tumor disease (DFTD) is a transmissible neoplasm that is threatening the survival of the Tasmanian devil. Genetic analyses have indicated that the disease is a peripheral nerve sheath neoplasm of Schwann cell origin. DFTD cells express genes characteristic of myelinating Schwann cells, and periaxin, a Schwann cell protein, has been proposed as a marker for the disease. Diagnosis of DFTD is currently based on histopathology, cytogenetics, and clinical appearance of the disease in affected animals. As devils are susceptible to a variety of neoplastic processes, a specific diagnostic test is required to differentiate DFTD from cancers of similar morphological appearance. This study presents a thorough examination of the expression of a set of Schwann cell and other neural crest markers in DFTD tumors and normal devil tissues. Samples from 20 primary DFTD tumors and 10 DFTD metastases were evaluated by immunohistochemistry for the expression of periaxin, S100 protein, peripheral myelin protein 22, nerve growth factor receptor, nestin, neuron specific enolase, chromogranin A, and myelin basic protein. Of these, periaxin was confirmed as the most sensitive and specific marker, labeling the majority of DFTD cells in 100% of primary DFTD tumors and DFTD metastases. In normal tissues, periaxin showed specificity for Schwann cells in peripheral nerve bundles. This marker was then evaluated in cultured devil Schwann cells, DFTD cell lines, and xenografted DFTD tumors. Periaxin expression was maintained in all these models, validating its utility as a diagnostic marker for the disease.

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Section: Discussionmentioning

confidence: 62%

Tumor-Specific Diagnostic Marker for Transmissible Facial Tumors of Tasmanian Devils

et al. 2011

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“…It is the most common soft tissue sarcoma of the pediatric population, accounting for up to 90% of these tumors [1] and up to 8% of all malignancies in children before adolescence [2]. Of the two histologic subtypes that occur in children, embryonal and alveolar, alveolar rhabdomyosarcomas are more common in adolescents than young children.…”

Section: Discussionmentioning

confidence: 99%

“…The fusion of these two genes results in a gain of function in which genes with PAX3 or PAX7 binding sites are activated. Although these two translocations result in a similar genetic outcome, tumors with the t(1;13) translocation have behaved less aggressively than those with the t(2;13) translocation [1].…”

Section: Discussionmentioning

confidence: 99%

Alveolar Rhabdomyosarcoma of the Paranasal Sinuses

Legendre

Nelson

2008

Head and Neck Pathol

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“…S ynovial sarcoma accounts for 5-14% of all soft tissue tumours [1,2]. Approximately 800 new cases occur in United States every year [1].…”

Section: Introductionmentioning

confidence: 99%

“…Approximately 800 new cases occur in United States every year [1]. Primary pulmonary sarcomas are extremely rare accounting for 0.1-0.5% of all lung malignancies [2,3].…”

Section: Introductionmentioning

confidence: 99%