Classical twin studies and beyond

Boomsma, Dorret I.; Busjahn, Andreas; Peltonen, Leena

doi:10.1038/nrg932

Cited by 982 publications

(845 citation statements)

References 61 publications

Supporting

Mentioning

800

Contrasting

Unclassified

Order By: Relevance

“…The sensitivity of brain structures to genetic or environmental factors is a topic of intense current interest as it may provide a means to link genetic or environmental causes with downstream behavioral and cognitive function. For example, regions that show significant heritability may be useful as intermediate phenotypes in the search for the genes responsible for neuropsychiatric disorders [Boomsma et al, 2002;Glahn et al, 2007]. Regions that instead show significant plasticity in response to environmental factors may represent areas with the potential for adaptive response.…”

Section: Discussionmentioning

confidence: 99%

Differences in genetic and environmental influences on the human cerebral cortex associated with development during childhood and adolescence

Lenroot

Schmitt

Ordaz

et al. 2007

Human Brain Mapping

302

260

View full text Add to dashboard Cite

In this report, we present the first regional quantitative analysis of age-related differences in the heritability of cortical thickness using anatomic MRI with a large pediatric sample of twins, twin siblings, and singletons (n 5 600, mean age 11.1 years, range 5-19). Regions of primary sensory and motor cortex, which develop earlier, both phylogenetically and ontologically, show relatively greater genetic effects earlier in childhood. Later developing regions within the dorsal prefrontal cortex and temporal lobes conversely show increasingly prominent genetic effects with maturation. The observation that regions associated with complex cognitive processes such as language, tool use, and executive function are more heritable in adolescents than children is consistent with previous studies showing that IQ becomes increasingly heritable with maturity(Plomin et al. [1997]: Psychol Sci 8:442-447). These results suggest that both the specific cortical region and the age of the population should be taken into account when using cortical thickness as an intermediate phenotype to link genes, environment, and behavior. Hum Brain Mapp 30: [163][164][165][166][167][168][169][170][171][172][173][174] 2009. V V C 2007 Wiley-Liss, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Differences in genetic and environmental influences on the human cerebral cortex associated with development during childhood and adolescence

Lenroot

Schmitt

Ordaz

et al. 2007

Human Brain Mapping

302

260

View full text Add to dashboard Cite

show abstract

“…MZ correlations twice as high as DZ/twin-sibling correlations indicate genetic influences. DZ correlations higher than half the MZ correlations suggest shared environmental influences, whereas MZ correlations that are of similar magnitude as DZ correlations indicate that only environmental influences play a role (Boomsma, Busjahn, & Peltonen, 2002 …”

Section: Genetic Analysesmentioning

confidence: 94%

Attention problems, inhibitory control, and intelligence index overlapping genetic factors: A study in 9-, 12-, and 18-year-old twins.

Polderman¹,

Geus²,

Hoekstra³

et al. 2009

Neuropsychology

View full text Add to dashboard Cite

It is assumed that attention problems (AP) are related to impaired executive functioning. We investigated the association between AP and inhibitory control and tested to what extent the association was due to genetic factors shared with IQ. Data were available from 3 independent samples of 9-, 12-, and 18-year-old twins and their siblings (1,209 participants). AP were assessed with checklists completed by multiple informants. Inhibitory control was measured with the Stroop Color Word Task (Stroop, 1935), and IQ with the Wechsler Intelligence Scale for Children (Wechsler et al., 2002) or Wechsler Adult Intelligence Scale (Wechsler, 1997). AP and inhibitory control were only correlated in the 12-year-old cohort (r ϭ .18), but appeared non-significant after controlling for IQ. Significant correlations existed between AP and IQ in 9-and 12-year olds (r ϭ Ϫ.26/-.34). Inhibitory control and IQ were correlated in all cohorts (r ϭ Ϫ.16, Ϫ.24 and Ϫ.35, respectively). Genetic factors that influenced IQ also influenced inhibitory control. We conclude that the association between AP and inhibitory control as reported in the literature may largely derive from genetic factors that are shared with IQ.

show abstract

“…Generally, twins can be used to obtain insights into the genetic epidemiology of complex traits and diseases, to study the interaction of geno-type with sex, age and lifestyle factors, and to study the causes of co-morbidity between traits and diseases. There are several national twin registers worldwide, which can offer unique opportunities for selected sampling for quantitative trait loci linkage and association studies (Boomsma, Busjahn & Peltonen 2002). …”

Section: Twin Studiesmentioning

confidence: 99%

Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

Karvinen

Silvennoinen

Vainio

et al. 2016

Experimental Gerontology

View full text Add to dashboard Cite

Classical twin studies and beyond

Cited by 982 publications

References 61 publications

Differences in genetic and environmental influences on the human cerebral cortex associated with development during childhood and adolescence

Differences in genetic and environmental influences on the human cerebral cortex associated with development during childhood and adolescence

Attention problems, inhibitory control, and intelligence index overlapping genetic factors: A study in 9-, 12-, and 18-year-old twins.

Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

Contact Info

Product

Resources

About