Classical osteosarcoma in children and adolescents

Dv, Rogozhin; Bulycheva,; Dm, Konovalov; Ag, Talalaev; Vy, Roshchin; Ap, Ektova; Yu, Bogoroditsky; Va, Strykov; An, Kazakova; Yu, Olshanskaya; Dy, Kachanov; Gv, Tereshchenko

doi:10.17116/patol201577568-74

Cited by 19 publications

(15 citation statements)

References 26 publications

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“…130,131 Ceramides are sphingolipids and play an important role in cell differentiation, cell cycle arrest, apoptosis, growth inhibition and senescence. 132 CUR has shown potent anticancer activity against all stages of cancer because of its action on NF-κB, TNF-α, VEGF, 133 combined CUR with C6 ceramide in liposomal nanoparticles to examine the antitumor potential against OS cell lines.…”

Section: Osteosarcomamentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

304

208

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Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

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Section: Osteosarcomamentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

304

208

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“…1 In recent years, much research has focused on the role of angiogenesis in osteosarcoma proliferation, migration, and metastasis. 2, 3, 4 Tumor angiogenesis has been recognized in the imbalance between pro-angiogenic and anti-angiogenic factors.…”

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confidence: 99%

WISP-1 positively regulates angiogenesis by controlling VEGF-A expression in human osteosarcoma

et al. 2017

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In recent years, much research has focused on the role of angiogenesis in osteosarcoma, which occurs predominantly in adolescents and young adults. The vascular endothelial growth factor-A (VEGF-A) pathway is the key regulator of angiogenesis and in osteosarcoma. VEGF-A expression has been recognized as a prognostic marker in angiogenesis. Aberrant WNT1-inducible signaling pathway protein-1 (WISP-1) expression is associated with various cancers. However, the function of WISP-1 in osteosarcoma angiogenesis is poorly understood. We demonstrate a positive correlation between WISP-1 and VEGF-A expression in human osteosarcoma. Moreover, we show that WISP-1 promotes VEGF-A expression in human osteosarcoma cells, subsequently inducing human endothelial progenitor cell (EPC) migration and tube formation. The focal adhesion kinase (FAK), Jun amino-terminal kinase (JNK), and hypoxia-inducible factor (HIF)-1α signaling pathways were activated after WISP-1 stimulation, while FAK, JNK, and HIF-1α inhibitors or small interfering RNA (siRNA) abolished WISP-1-induced VEGF-A expression and angiogenesis. In vitro and in vivo studies revealed down-regulation of microRNA-381 (miR-381) in WISP-1-induced VEGF-A expression and angiogenesis. Our findings reveal that WISP-1 enhances VEGF-A expression and angiogenesis through the FAK/JNK/HIF-1α signaling pathways, as well as via down-regulation of miR-381 expression. WISP-1 may be a promising target in osteosarcoma angiogenesis.

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“…Osteosarcoma (OS) is a prevalent primary malignant bone tumor [1] predominantly affects children and adolescents [2]. OS typically occurs in the metaphysis of long bones [3] and has a high incidence of lung metastasis and local aggressiveness [4]. The survival rate of OS is 60-70% after surgery and neoadjuvant chemotherapy [5,6].…”

Section: Introductionmentioning

confidence: 99%

ACTN4 Promotes the Proliferation, Migration, Metastasis of Osteosarcoma and Enhances its Invasive Ability through the NF-κB Pathway

Huang

et al. 2019

Pathol. Oncol. Res.

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Alpha-actinin-4 (ACTN4) is associated with different types of tumors, but its role in osteosarcoma (OS) is not known. We aimed to investigate the effect of ACTN4 on the growth, migration, invasion and metastasis of OS. We further explored the possible mechanism of how ACTN4 affects the development of OS. First, the expression of ACTN4 in OS tissues and OS cell lines was analyzed by PCR. Second, the role of ACTN4 in the development of OS was explored by the proliferation, scratch, and invasion assays. We further explored the effect of ACTN4 on OS growth in an orthotopic xenograft model of nude mice. In addition, we used hematoxylin and eosin (HE) staining of lung tissues in nude mice to observe the effect of ACTN4 on lung metastasis of OS. Finally, rescue experiments further investigated the role of NF-κB on ACTN4 in the development of OS. ACTN4 was highly expressed in OS tissues and OS cell lines. In vitro experiments demonstrated that reducing ACTN4 expression inhibited the proliferation, migration, and invasion of OS. In contrast, overexpression of ACTN4 promotes these effects. In vivo experiments further validated that ACTN4 promoted the growth of OS. The HE staining of lungs in nude mice revealed that ACTN4 promoted lung metastasis of OS. In addition, we found that ACTN4 enhanced the ability of OS to invade, through the NF-κB pathway. ACTN4 promotes the proliferation, migration, metastasis of OS and enhances its invasion ability through the NF-κB pathway.

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Classical osteosarcoma in children and adolescents

Cited by 19 publications

References 26 publications

Liposomal curcumin and its application in cancer

Liposomal curcumin and its application in cancer

WISP-1 positively regulates angiogenesis by controlling VEGF-A expression in human osteosarcoma

ACTN4 Promotes the Proliferation, Migration, Metastasis of Osteosarcoma and Enhances its Invasive Ability through the NF-κB Pathway

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