Classic Kaposi's sarcoma treated with topical 0.5% timolol gel

Alcántara-Reifs, Carmen María; Salido‐Vallejo, Rafael; Garnacho‐Saucedo, Gloria; García-Nieto, Antonio Vélez

doi:10.1111/dth.12381

Cited by 23 publications

(22 citation statements)

References 8 publications

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“…To date, there have been eight cases published reporting the use of topical timolol to treat CKS ( Table 1) [5][6][7][8]. Notably, the median age of reported cases was 74.5 years with a majority (75%) being male, consistent with the known demographics of CKS.…”

Section: Discussionmentioning

confidence: 68%

Failed Treatment of Classic Kaposi’s Sarcoma with Topical Timolol: Case Report and Review of the Literature

Gupta¹,

DeBord²,

Dao³

2019

Cureus

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Classic Kaposi’s sarcoma (CKS) is an angioproliferative cutaneous neoplasm which currently lacks a well-defined treatment regimen. Because the disease is often localized, topical therapies offer therapeutic potential without the morbidity of systemic or surgical treatment. Timolol, a topical β-adrenergic receptor antagonist, has shown promise in the treatment of CKS in individual cases. Here we report a patient with classic Kaposi’s sarcoma who failed treatment with 0.5% topical timolol three times daily for 12 weeks. Topical timolol use has been previously reported in eight patients with CKS who all responded to treatment with no adverse effects. Our divergent experience from the literature implies that while topical timolol may be an effective and safe treatment alternative to traditional therapies for patients with CKS, further prospective studies are needed.

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Section: Discussionmentioning

confidence: 68%

Failed Treatment of Classic Kaposi’s Sarcoma with Topical Timolol: Case Report and Review of the Literature

Gupta¹,

DeBord²,

Dao³

2019

Cureus

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“…[9] It has been used successfully in the management of pyogenic granuloma, classic Kaposi's sarcoma, graft-versus-host disease associated angiomatosis, idiopathic pyoderma gangrenosum and recalcitrant wounds. [1011121314]…”

Section: Discussionmentioning

confidence: 99%

Angiolymphoid hyperplasia with eosinophilia and its response to the combination of radiofrequency ablation and topical timolol

Arora

Meena

Sharma

et al. 2017

Indian Dermatol Online J

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Angiolymphoid hyperplasia with eosinophilia is a rare vascular disease characterized by multiple erythematous to violaceous papules, commonly present on the head and neck region. We report a case of a 23-year-old female who presented with multiple, erythematous asymptomatic papules on the preauricular region and pinna, which on biopsy was suggestive of angiolymphoid hyperplasia. The lesions were treated with a novel combination of radiofrequency ablation and topical timolol. The lesions healed without scarring and there was no recurrence on 1 year follow up.

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“…A Spanish case study in 2015 with two HIVnegative KS patients reported significant response with no adverse effect and no recurrence after 20 months using 0.5% topical timolol twice daily for 12 weeks. 28 Interestingly, three classic KS patients achieved complete resolution and one HIV-associated KS patient showed significant improvement using 0.1% topical timolol instead of 0.5% topical timolol. 28 Interestingly, three classic KS patients achieved complete resolution and one HIV-associated KS patient showed significant improvement using 0.1% topical timolol instead of 0.5% topical timolol.…”

Section: Kaposi Sarcomamentioning

confidence: 94%

“…27 A later case report including two patients with localized classic KS also achieved complete clinical response using 0.5% timolol gel twice daily for 12 and 18 weeks. 28 Interestingly, three classic KS patients achieved complete resolution and one HIV-associated KS patient showed significant improvement using 0.1% topical timolol instead of 0.5% topical timolol. 29 Local treatment with topical b-blocker is painless, inexpensive and promising alternative for classic KS patients.…”

Section: Kaposi Sarcomamentioning

confidence: 94%

The role of β‐blockers in dermatological treatment: a review

Chen

Tsai

2017

Acad Dermatol Venereol

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Many systemic medications have been used off-label in cutaneous diseases. Use of β-adrenergic-blocking agents has risen in popularity among dermatologists since the discovery of their efficacy in treating infantile haemangioma. There has also been an increase in the interest of the applications of β-blockers in other skin disorders. Overall, β-blockers are effective in treating diseases of vascular origin and promote wound healing. They are relatively safe and inexpensive medications that could be included in the armamentarium against skin diseases.

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Classic Kaposi's sarcoma treated with topical 0.5% timolol gel

Cited by 23 publications

References 8 publications

Failed Treatment of Classic Kaposi’s Sarcoma with Topical Timolol: Case Report and Review of the Literature

Failed Treatment of Classic Kaposi’s Sarcoma with Topical Timolol: Case Report and Review of the Literature

Angiolymphoid hyperplasia with eosinophilia and its response to the combination of radiofrequency ablation and topical timolol

The role of β‐blockers in dermatological treatment: a review

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