Class II (DR) antigen expression on CD8+ lymphocyte subsets in acquired immune deficiency syndrome (AIDS)

Ziegler‐Heitbrock, H. W. L.; Stachel, Daniel; Schlunk, T.; Gürtler, Lutz; Schramm, W.; Fröschl, M.; Bogner, J. R.; Riethmüller, Gert

doi:10.1007/bf00916953

Cited by 34 publications

(13 citation statements)

References 13 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HIV-speciflc CTL activity CTL activity against HlV-gag, tat, pal and env is shown in Figs I and 2 for HIV-infected (nos 1-9) and uninfected (nos [11][12][13][14][15][16][17][18][19][20] children, respectively. Results are presented as the per cent specific lysis net of medium and vaccinia controls, with values greater than 10% above controls being regarded as positive.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic T lymphocyte activity and CD8 subpopulations in children at risk of HIV infection

Aldhous

Watret²,

Mok

et al. 1994

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARYHIV-specific cytotoxic T lymphocytes (CTL) are thought to play a major role in viral control in HIV-infected adults. Changes in the relative proportions of CDS lymphocyte subpopulations are also thought to be associated with disease progression. Less is known about the relative effectiveness of CTL against different HIV targets, or about the relationship, if any. between CTL activity and CDS subpopuiations. We have measured CTL activity against four HIV gene products (gag. tat. pal and en\) and expression of CD45RO, CD45RA. HLA-DR, CD29. S6F1, and CD57 surface markers on CDS cells from nine HIV-infected and 11 HIV-uninfected children. Of nine HIV-infected children, six showed antigen-specific CTL activity on at least one occasion: 4/6 directed against tat, 6/6 against pol, 1/6 against env, and 1/6 against gag. However, the specificity of the CTL activity varied between children and within individual children with time. Furthermore, two uninfected children showed CTL activity, one to HW-gag. -pot and -tat. and the other to HW-pot. All the HIV-infected and two uninfected children had abnormal proportions of CDS subpopulations in whole blood compared with age-matched controls. There was no correlation between CTL activity and CDS subsets in whole blood. Five children changed from CTL-positive to CTL-negative (or vice versa) during the study. In these, the occasions when CTL activity was detected coincided with an increase in CDS cells, an expansion of HLA-DR^ CD8 cells and a loss of CD45RA ' CDS cells.

show abstract

Section: Resultsmentioning

confidence: 99%

Cytotoxic T lymphocyte activity and CD8 subpopulations in children at risk of HIV infection

Aldhous

Watret²,

Mok

et al. 1994

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…HIV-infected patients are characterized by chronically stimulated cell-mediated immunity [20,21] and by relative CD8 ϩ lymphocytosis with a decrease in the percentage of CD28 ϩ cells but an increase in the percentage of CD28 Ϫ cells [9][10][11][12]. Therefore, freshly collected PBMCs were analyzed to evaluate the presence of CD28 dim T cells in blood samples obtained from HIV-infected patients.…”

Section: Discussionmentioning

confidence: 99%

“…It should therefore be possible to observe, in long-term-stimulated CD28 ϩ cells, the emergence in time of elements characterized by a lower CD28 molecule expression. Cells with an intermediate CD28 expression level should also be present in HIV ϩ patients, characterized by chronic activation of cell-mediated immunity [20,21]. This article describes the presence of CD8 ϩ cells with an intermediate CD28 phenotype, both at the clonal level and in freshly-collected peripheral blood mononuclear cells (PBMCs), and demonstrates that these may derive from both CD28 ϩ and CD28 Ϫ subsets, possibly as an intermediate CD28 phenotype during a normal pattern of functional CD8 ϩ T cell maturation.…”

Section: Introductionmentioning

confidence: 99%

Generation of CD28− cells from long-term-stimulated CD8+CD28+ T cells: a possible mechanism accounting for the increased number of CD8+CD28− T cells in HIV-1-infected patients

Fiorentini

Malacarne

Ricotta

et al. 1999

Journal of Leukocyte Biology

View full text Add to dashboard Cite

According to CD28 molecule expression, CD8 ؉ T cells can be classed as CD28 bright , CD28 dim , and CD28 ؊ . The CD28 dim T cells were found to derive from mitogenic stimulated CD28 ؊ T cells but also from CD28 bright T cells through a mechanism of CD28 down-modulation. Moreover, after prolonged in vitro interleukin-2 stimulation, clonal CD28 bright cells showed a CD28 dim expression before further evolution to a stable CD28 ؊ phenotype. This loss was concomitant with the disappearance of CD28 mRNA. A study of the cytokine production pattern revealed that CD28 dim and CD28 ؊ T cell clones produced similar levels of type 1 and type 2 cytokines, which differed from those produced by the CD28 bright T cell clones. A high percentage of CD28 dim and CD28 ؊ cells, with similarities in their cytokine production pattern, were found in the blood samples of HIV-infected patients, as compared to healthy donors. The CD28 down-modulation may account for the increased number of CD8 ؉ CD28 ؊ T cells in HIV-infected patients. J. Leukoc. Biol. 65: 641-648; 1999.

show abstract

“…In the late stages ARC and AIDS most of the CD8 + cells also carry the CD38 molecule ( Figure 5). Two colour flow cytometry using CD57 shows that CD8 + CD57 + as well as CD8 + CD57-cells expand in early HIV infection [15,16,4]. A similar expansion is seen in rejection of renal allografts [17].…”

Section: S105mentioning

confidence: 56%

“…A similar expansion is seen in rejection of renal allografts [17]. Functionally CD8 + CD38 + and CD8 + CD57 + lymphocytes are in volved in cytotoxicity against HIV-infected cellular targets [15]. In addition, antibody dependent cytotoxicity (ADCC) is triggered by antibodies to HIV antigens and may be conveyed by this cell type.…”

Section: S105mentioning

confidence: 63%

Lymphozytensubpopulationen als Surrogatmarker bei antiretroviraler Therapie

Bogner

Goebel

1991

Infection

Self Cite

View full text Add to dashboard Cite

Class II (DR) antigen expression on CD8+ lymphocyte subsets in acquired immune deficiency syndrome (AIDS)

Cited by 34 publications

References 13 publications

Cytotoxic T lymphocyte activity and CD8 subpopulations in children at risk of HIV infection

Cytotoxic T lymphocyte activity and CD8 subpopulations in children at risk of HIV infection

Generation of CD28− cells from long-term-stimulated CD8+CD28+ T cells: a possible mechanism accounting for the increased number of CD8+CD28− T cells in HIV-1-infected patients

Lymphozytensubpopulationen als Surrogatmarker bei antiretroviraler Therapie

Contact Info

Product

Resources

About