Class II antigen expression on human cultured Schwann cells from patients with Charcot-Marie-Tooth disease

Martini, Isabella; Bianchini, Daria; Schenone, Angelo; Cadoni, Angela; Zicca, A; Zaccheo, D; Mancardi, Gianluigi

doi:10.1016/0304-3940(89)90708-8

Cited by 9 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 The addition of autologous cells would not, however, diminish the number of donor Schwann cells in the graft expressing MHC-I and MHC-II antigens. 1,3 As such, the immune response to the nerve allograft seeded with autologous Schwann cells should not be significantly altered, and a full dose of immunosuppression would be required to prevent rejection of the antigenic load. Clinically, we have had a single case of nerve allograft rejection, 59 which prompted us to study the abilities of CsA, 60 and the immunosuppressant FK506 58 to treat peripheral nerve rejection.…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral nerve allografts represent a reconstructive alternative, but are limited by the need for immunosuppression. Donor Schwann cells, which express alloantigen, [1][2][3] and host Schwann cells, which function as antigen-presenting cells (APCs) to Tlymphocytes, 4 are both involved in the immune response to peripheral nerve allografts. Immunosuppressive agents such as Cyclosporin A (CsA), 5 and FK506 6,7 prevent the rejection of donor nerve Schwann cells, and enable axonal regeneration through the allograft nerve segment.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Safe injection of cultured Schwann cells into peripheral nerve allografts

et al. 2000

View full text Add to dashboard Cite

The effects of cultured host Schwann cells on axonal regeneration in peripheral nerve allografts were studied. Fischer rats served as recipient animals and Buffalo rats provided nerve allografts. Animals were randomized into 9 groups. Rats receiving tibial nerve isografts were left untreated (group I), or injected with isogeneic Fischer Schwann cells (group II) or placebo suspension (group III). Allografts obtained from Buffalo rats were left untreated (group IV), or received isogeneic Fischer Schwann cells (group V), 2 mg/kg Cyclosporin A and Fischer Schwann cells (group VI), 5 mg/kg Cyclosporin A (group VII), or 5 mg/kg Cyclosporin A with Schwann cells (group VIII). No Schwann cell tumors were identified 4 or 8 weeks postoperatively. Group IX animals, harvested 3 days postoperatively, demonstrated no evidence of injection injury. Schwann cells modestly improved axonal regeneration in both isografts and allografts and may have a clinical role in the treatment of peripheral nerve allografts.Inbred Fischer rats CDF (F-344; n ‫ס‬ 84) were transplanted with either a 1.5-cm tibial nerve isograft from a

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Safe injection of cultured Schwann cells into peripheral nerve allografts

et al. 2000

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Safe injection of cultured Schwann cells into peripheral nerve allografts

et al. 2000

View full text Add to dashboard Cite

The effects of cultured host Schwann cells on axonal regeneration in peripheral nerve allografts were studied. Fischer rats served as recipient animals and Buffalo rats provided nerve allografts. Animals were randomized into 9 groups. Rats receiving tibial nerve isografts were left untreated (group I), or injected with isogeneic Fischer Schwann cells (group II) or placebo suspension (group III). Allografts obtained from Buffalo rats were left untreated (group IV), or received isogeneic Fischer Schwann cells (group V), 2 mg/kg Cyclosporin A and Fischer Schwann cells (group VI), 5 mg/kg Cyclosporin A (group VII), or 5 mg/kg Cyclosporin A with Schwann cells (group VIII). No Schwann cell tumors were identified 4 or 8 weeks postoperatively. Group IX animals, harvested 3 days postoperatively, demonstrated no evidence of injection injury. Schwann cells modestly improved axonal regeneration in both isografts and allografts and may have a clinical role in the treatment of peripheral nerve allografts. © 2000 Wiley‐Liss, Inc. MICROSURGERY 20:314–323 2000

show abstract