Clarithromycin treatment selects for persistent macrolide-resistant bacteria in throat commensal flora

Jönsson, Maria; Qvarnström, Yvonne; Engstrand, Lars; Swedberg, Göte

doi:10.1016/j.ijantimicag.2004.08.011

Cited by 9 publications

(17 citation statements)

References 20 publications

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“…The use of leftover drugs may increase antimicrobial drug resistance in the community by exerting selective pressure in the commensally flora (12) .Evidence shows that repeated treatment with antimicrobial drugs exerts greater selective pressure on normal bacterial flora than a single course of treatment (13).Consequently, persons who use leftover antimicrobial drugs repeatedly are at greater risk for colonization and infection with drug resistant organisms(12).…”

Section: Resultsmentioning

confidence: 99%

Statically study of third generation Cephalosporin (Cefotaxime) quantities uses in some Iraqi provinces

2017

Int. J. Adv. Multidiscip. Res.

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The present study deal with the percentage of quantities uses of Cefotaxime in some Iraqi provincesthe areas of the Middle Euphrates (Babel, Karbala, Najaf, Qadissiyah and Muthanna) and southern Iraq (Basra, DhiQar and Maysan) for the year 2012 based on the data for one of the pharmaceutical companies in Iraq, known as Zentiva a branch of Sanofi French company which is famous stiffly medicine Sefotak ® a name trade pharmaceutical substance effective Cefotaxime. The results of present study showed that the highest percentage of the using of this drug were in the provinces of Babylon and Basra 36.21% and 22.16% respectively, compared with other provinces (Karbala 3.94% , Najaf 4.69% , Qadisiyah 9.34% , Muthanna , 1.59%, DhiQar 7.88% and Maysan 14.15%).While the total percentages of whole areas of the Middle Euphrates was highest in use of Cefotaxime compare with southern regions about 55.79% and 44.20%, respectively.

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Section: Resultsmentioning

confidence: 99%

Statically study of third generation Cephalosporin (Cefotaxime) quantities uses in some Iraqi provinces

2017

Int. J. Adv. Multidiscip. Res.

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“…DNA preparations and polymerase chain reaction (PCR) were performed as described in Jönsson et al [1]. Owing to a change in nomenclature standards, the gene then specified as mef(A) will now be referred to as mef(A/E) or mef(E).…”

Section: Detection Of the Mega Element And Tn12071mentioning

confidence: 99%

“…We have previously characterised ␣-haemolytic streptococci from a selection of patients included in the DalaHP study and screened for the presence of mef(A/E) and erm(B) genes [1]. From the isolates carrying one or both of these genes, three isolates from different patients were chosen as donors in the mating experiments.…”

Section: Transfer Of Macrolide Resistancementioning

confidence: 99%

“…We report the presence of a MEGA-like element carrying the mef(E) gene in a collection of Swedish ␣-haemolytic streptococci originating from the DalaHP study [1] as well as conjugal transfer of this element and of erm(B) genes from the commensal streptococci to the pathogen Streptococcus pyogenes BM137.…”

Section: Introductionmentioning

confidence: 99%

“…We have investigated the long-term effects of standard ulcer treatment with the macrolide clarithromycin on the throat commensal flora [1]. The two most common mechanisms conferring macrolide resistance in streptococci are macrolide efflux proteins encoded by mef genes and rRNA methylases encoded by erm genes [2].…”

Section: Introductionmentioning

confidence: 99%

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Macrolide resistance can be transferred by conjugation from viridans streptococci to Streptococcus pyogenes

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What Would the Screen-and-Treat Strategy for Helicobacter pylori Mean in Terms of Antibiotic Consumption?

Leja

Dumpis

2019

Dig Dis Sci

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Several guidelines recommend the screen-and-treat strategy, i.e. active search for the presence of Helicobacter pylori infection and its eradication to prevent the possibility of gastric cancer. It is thought that a relatively short duration antibiotic regimen given once in a lifetime would not significantly increase overall antibiotic consumption. However, this would mean offering antibiotic treatment to the majority of the population in countries with the biggest burden of gastric cancer who would, therefore, have the greatest benefit from such a strategy. So far, no country has implemented an eradication strategy. With an example based on the current situation in Latvia, we have estimated the increase in antibiotic consumption if the screen-and-treat strategy was applied. Depending on the scenario that might be chosen, clarithromycin consumption would increase up to sixfold, and amoxicillin consumption would double if the recommendations of the current guideline in the local circumstances was applied. It appears that an increase in commonly used antibiotic consumption cannot be justified from the viewpoint of antibiotic stewardship policies. Solutions to this problem could be the use of antibiotics that are not required for treating life-threatening diseases or more narrow selection of the target group, e.g. young people before family planning to avoid transmission to offspring. Additional costs related to the increase in resistome should be considered for future cost-effectiveness modelling of the screen-and-treat strategy.

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Clarithromycin treatment selects for persistent macrolide-resistant bacteria in throat commensal flora

Cited by 9 publications

References 20 publications

Statically study of third generation Cephalosporin (Cefotaxime) quantities uses in some Iraqi provinces

Statically study of third generation Cephalosporin (Cefotaxime) quantities uses in some Iraqi provinces

Macrolide resistance can be transferred by conjugation from viridans streptococci to Streptococcus pyogenes

What Would the Screen-and-Treat Strategy for Helicobacter pylori Mean in Terms of Antibiotic Consumption?

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