The present study deal with the percentage of quantities uses of Cefotaxime in some Iraqi provincesthe areas of the Middle Euphrates (Babel, Karbala, Najaf, Qadissiyah and Muthanna) and southern Iraq (Basra, DhiQar and Maysan) for the year 2012 based on the data for one of the pharmaceutical companies in Iraq, known as Zentiva a branch of Sanofi French company which is famous stiffly medicine Sefotak ® a name trade pharmaceutical substance effective Cefotaxime. The results of present study showed that the highest percentage of the using of this drug were in the provinces of Babylon and Basra 36.21% and 22.16% respectively, compared with other provinces (Karbala 3.94% , Najaf 4.69% , Qadisiyah 9.34% , Muthanna , 1.59%, DhiQar 7.88% and Maysan 14.15%).While the total percentages of whole areas of the Middle Euphrates was highest in use of Cefotaxime compare with southern regions about 55.79% and 44.20%, respectively.