Clarifying the Relationship Between ABO/Rhesus Blood Group Antigens and Upper Gastrointestinal Bleeding

Bayan, Kadim; Tüzün, Yekta; Yilmaz, Şerif; Dursun, Mehmet; Canoruç, Fikri

doi:10.1007/s10620-008-0446-0

Cited by 27 publications

(18 citation statements)

References 26 publications

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“…Moreover, the percentage of H. pylori-positive patients presented with DUs was higher than GU patients in the present study, with epigastric pain as a major complaint as reported by many others [48,67,68]. Higher incidence of H. pylori infection was within blood Group O phenotype patients with Rh positivity compared to other blood groups [69,70]. Many other studies showed higher frequency of DU among patients with blood Group O with significantly higher H. pylori positivity [47,52], including Iraqi population [70].…”

Section: Demographic Data and Disease Characteristics Of Patients Witsupporting

confidence: 56%

Clinical Evaluation of Triple and Quadruple Helicobacter Pylori Eradication Therapy in Peptic Ulcer Patients With Different Abo Blood Group Phenotypes

Abdulridha

Kutaif

Kamal

et al. 2018

Asian J Pharm Clin Res

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Objective: This study aimed to examine the pathological changes in gastric mucosa of Helicobacter pylori-infected peptic ulcer patients carrying different ABO phenotypes and to study the response to the 14 days' standard triple therapy and 10 days' quadruple therapy in peptic ulcer patients according to their ABO phenotypes. Methods:Interventional prospective randomized-controlled open-label study was performed on newly diagnosed patients with PUD. The H. pyloripositive patients were allocated into two major study groups in which they are subdivided according to ABO blood group phenotypes: Group 1 received standard H. pylori eradication triple therapy and Group 2 received standard H. pylori eradication quadruple regimen. Patients were monitored after 2 months for successful H. pylori eradication.Results: Chronic active gastritis was significantly high in patients carrying blood Group O phenotype (81.25%), while the atrophic gastritis and intestinal metaplasia were significantly high in patients carrying blood Group A phenotype (25.00% and 16.67%), respectively. 14 days' triple therapy showed significantly lower eradication rate in H. pylori-infected peptic ulcer patients carrying blood Group O phenotype (p<0.01), meanwhile higher response was found among patients with blood Group B. 10 days' quadruple therapy produced a significant high eradication rate in H. pylori-infected patients carrying blood Group O than those with blood Group A (p<0.01), but still both showed lower response compared to that in patients carrying blood Group B and AB phenotypes. Elderly patients showed significantly less healing efficacy than younger patients (p<0.01), and the least healing rate was noticed in female patients after both regimens. Conclusion:Lower eradication rate in H. pylori-infected was noticed in peptic ulcer patients carrying blood Group O mainly than those with other blood groups and particularly those with duodenal Ulceri. 10 days' quadruple therapy showed significant higher eradication rate in H. pylori infection and a better ulcer healing efficacy.

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Section: Demographic Data and Disease Characteristics Of Patients Witsupporting

confidence: 56%

Clinical Evaluation of Triple and Quadruple Helicobacter Pylori Eradication Therapy in Peptic Ulcer Patients With Different Abo Blood Group Phenotypes

Abdulridha

Kutaif

Kamal

et al. 2018

Asian J Pharm Clin Res

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“…Another association of the ABO blood group phenotypes refers to the incidence of haemorrhage of the upper gastrointestinal tract due to stomach ulcer. As a relevant study demonstrated, the incidence of haemorrhage of the upper gastrointestinal tract presents to be higher for the O blood group, as well as for the people classified as Rh + (Bayan et al. , 2009).…”

Section: Introductionmentioning

confidence: 96%

Distribution of ABO and Rh blood groups in Greece: an update

Lialiaris

Digkas

Kareli

et al. 2011

International Journal of Immunogenetics

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The aim of this study was to investigate and evaluate the frequency of the antigens classifying the ABO and Rh blood groups in the Greek population. In this study the 3.5% were first generation immigrants with both their parents immigrants from countries of the USSR, while 1.2% had only one immigrant parent, while the other one was Greek. We compared the frequency of distribution of blood groups ABO and Rh to previous studies conducted at a time before Greece became destination for refugees and immigrants from East and Northeast countries. Blood samples were collected from first year medical students. The frequency of distribution of the ABO and Rh blood groups was slightly differentiated in comparison to previous relevant studies. Significant increase was recorded with respect to the emergence of blood group B in the population investigated, and a considerable reduction was noted in blood group O. In reference to the remaining blood groups, no statistically significant difference was documented. The genetic pool and the genetic inventory of the population residing in Greece have been modified during the last years potentially due to the first generation immigrants. The results of this study could contribute significantly to the National Health System in aiding the prediction of percussions of certain diseases related to blood groups, as well as the requirement for certain blood groups within the blood donation program.

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“…It seems that vWf levels are 25% higher in non-O compared to group O individuals 16 . An interesting finding is that the rebleeding rate between patients with different blood groups was similar 40 . At the same time, some other studies find determination of blood groups not being a useful tool to determine the individual risk for gastroduodenal ulcer and ulcer bleeding 41,42 .…”

Section: Discussionmentioning

confidence: 84%

“…The relationship between blood group antigens and peptic ulcer disease, especially with upper gastrointestinal bleeding was widely evaluated in the past and one of the studies found that the blood group O had higher frequency in the group with bleeding ulcer than in the control group compared to other blood groups 40 . The reason for bleeding is due to the level of the circulating plasma protein von Willebrand factor 15 .…”

Section: Discussionmentioning

confidence: 99%

Bleeding gastroduodenal ulcers in patients without Helicobacter pylori infection and without exposure to non-steroidal anti-inflammatory drugs

Smolović

Stanisavljević²,

Golubović

et al. 2014

VOJNOSANIT PREGL

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Clarifying the Relationship Between ABO/Rhesus Blood Group Antigens and Upper Gastrointestinal Bleeding

Abstract: ABO blood group O had an important role in patients with upper gastrointestinal bleeding. The impact of blood group on rebleeding and mortality may be a focus for further studies.

Cited by 27 publications

References 26 publications

Clinical Evaluation of Triple and Quadruple Helicobacter Pylori Eradication Therapy in Peptic Ulcer Patients With Different Abo Blood Group Phenotypes

Clinical Evaluation of Triple and Quadruple Helicobacter Pylori Eradication Therapy in Peptic Ulcer Patients With Different Abo Blood Group Phenotypes

Distribution of ABO and Rh blood groups in Greece: an update

Bleeding gastroduodenal ulcers in patients without Helicobacter pylori infection and without exposure to non-steroidal anti-inflammatory drugs

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