Clara cell 10 kDa protein (CC10): Comparison of structure and function to uterogloblin

Singh, Gurmukh; Katyal, Sikandar L.; Brown, William E.; Kennedy, Ann C.; Singh, Ushasi; Wong-Chong, Mari Lou

doi:10.1016/0167-4838(90)90270-p

Cited by 110 publications

(73 citation statements)

References 36 publications

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“…Table 1 shows the similarity data between FHG22 and each of the mentioned cDNAs/polypeptides. FHG22 nucleotide and amino acid sequences display a lower degree of similarity to the UG/CCI0 from several species than those between the rabbit, rat and human homologs [33], indicating that FHG22 is not the hamster UG subunit, and, similarly, suggesting that FHG22 is neither the hamster version of FdI 1 nor msABP ct. However, the identity and similarity data imply a relationship between FHG22 and all those genes/polypeptides [11,34], and their belonging to a common new protein family.…”

Section: Comparisons Of the Fhg22 Nucleotide And Amino Acid Sequencesmentioning

confidence: 95%

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Cloning of a Syrian hamster cDNA related to sexual dimorphism: establishment of a new family of proteins

Domı́nguez

1995

FEBS Letters

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The clone FHG22, isolated from a female minus male subtracted cDNA library obtained from the sexually dimorphic Syrian hamster Harderian glands (HG) is 440 bp long with a 95 amino acids ORF, and hybridizes to a female HG-specific 0.6 kb mRNA. The FHG22 nucleotide and amino acid sequences are similar to the subunits from prostatein, uteroglobin, major cat allergen Fel dI (chain 1) and mouse salivary androgen binding proteins (subunit o 0. Therefore I propose that all those polypeptides belong to a common new family. The hamster genome has a single copy of the FHG22 gene, without homologous genes. FHG22 mRNA is also found in male and female parotid (higher levels in females) and submandibular glands, indicating a tissue and sex-dependent control of expression.

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Section: Comparisons Of the Fhg22 Nucleotide And Amino Acid Sequencesmentioning

confidence: 95%

“…parison of the nucleotide-deduced sequences (not available for msABP ~) to those from the purified mature polypeptides [11,14,15,30,31,32,33,35]. Similarly, the first 21 amino acids in the FHG22 sequence could also be a signal peptide for protein secretion [28].…”

Section: Male Femalementioning

confidence: 99%

Cloning of a Syrian hamster cDNA related to sexual dimorphism: establishment of a new family of proteins

Domı́nguez

1995

FEBS Letters

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“…In addition, the protein is also secreted b y the male urogenital tract from puberty on (7). It is identical to protein 1, an a-microprotein isolated from the urine of patients with tubular proteinuria (7), and presents a 61% sequence homology with rabbit uteroglobulin (4,7,8). The Mr of human CC16, determined by electro-spray ionization/mass spectrometry, is 15 840 (9).…”

mentioning

confidence: 94%

“…Evidence available to date suggests that it might be an immunosuppressive or antiinflammatory protein protecting the respiratory and urogenital tracts from exaggerated inflammatory reactions (3,4,7,8). This evidence is based on the finding that CC16 inhibits phospholipase A, and on the marked sequence similarity with rabbit uteroglobulin, which reportedly has immunosuppressive, antiinflammatory, antiproteinase, and antiphospholipase A, activity (4,8). 'Because of anomalous migration properties, CC16 shows by SDS-PAGE an M, of 10 000.…”

mentioning

confidence: 99%

“…The time course of CC16 in amniotic fluid during normal pregnancy and its reduction in pathologies associated with lung hypoplasia suggest that CC16 in amniotic fluid might serve as a marker of bronchial epithelium growth. (Pediatr Res 36: 771-775, 1994) Abbreviations CC16, Clara cell protein RDS, respiratory distress syndrome CC16 is a lung secretory protein that has been described in rodents and humans (1)(2)(3)(4)(5). Initially, CC16 was described as a specific product of the Clara cells, which are nonciliated cells predominantly localized in respiratory and terminal bronchioles (hence the name Clara cell protein).…”

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Clara Cell Protein in Human Amniotic Fluid: A Potential Marker of Fetal Lung Growth

et al. 1994

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Clara cell protein (CC16) is a 16-kD protein secreted at the surface of respiratory airways by nonciliated bronchial and bronchiolar cells, including Clara cells. Using the same immunoassay as that recently developed for CC16 in lung lavage, we have measured CC16 in amniotic fluid samples from 100 normal fetuses and 51 fetuses with various pathologies. Ouchterlony immunodiffusion analysis showed a complete identity between CC16 in amniotic fluid and the protein in lung lavages of adults. CC16 was detectable in amniotic fluid from about the 15th wk of pregnancy, then progressively increased until delivery, with a tendency to reach a plateau after the 30th wk. Between the 15th and the 39th wk of pregnancy, the concentration of CC16 in amniotic fluid increased on average 25 times. The sex of the fetus did not influence the concentration of CC16 in amniotic fluid. Compared with expected values, levels of CC16 in amniotic fluid were on average not significantly altered in cases of spina bifida (n = 9), anencephaly (n = 7), and trisomy 21 (n = 6). In contrast, CC16 was on average significantly decreased in cases of diaphragmatic hernia (n = 6), trisomy 18 (n = 14), Turner syndrome (n = 4), and diabetic pregnancy (n = 5). In cases of diaphragmatic hernia, a relation emerged between the concentration of CC16 in amniotic fluid and both the weight of the lungs and the survivorship of the fetuses. The time course of CC16 in amniotic fluid during normal pregnancy and its reduction in pathologies associated with lung hypoplasia suggest that CC16 in amniotic fluid might serve as a marker of bronchial epithelium growth. (Pediatr Res 36: 771-775, 1994)

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Atypical adenomatous hyperplasia and adenocarcinoma of the human lung: Their heterology in form and analogy in immunohistochemical characteristics

Mori¹,

Tezuka²,

Chiba³

et al. 1996

Cancer

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Clara cell 10 kDa protein (CC10): Comparison of structure and function to uterogloblin

Cited by 110 publications

References 36 publications

Cloning of a Syrian hamster cDNA related to sexual dimorphism: establishment of a new family of proteins

Cloning of a Syrian hamster cDNA related to sexual dimorphism: establishment of a new family of proteins

Clara Cell Protein in Human Amniotic Fluid: A Potential Marker of Fetal Lung Growth

Atypical adenomatous hyperplasia and adenocarcinoma of the human lung: Their heterology in form and analogy in immunohistochemical characteristics

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