Objective:
Measures of glycaemic impact (e.g., postprandial glucose (PPG), oral glucose tolerance test (OGTT), and glycaemic index (GI)) are used by government health and regulatory agencies and public health associations around the world. The objective of this global review was to identify similarities and differences in the use of glycaemic impact measures for potential considerations for harmonization.
Design:
A literature and internet search was conducted to identify country government agencies and health associations that provide guidance or recommendations for PPG, OGTT, GI and glycaemic load.
Results:
Based on this global review, the use of GI for food labeling (e.g., low GI) is limited and its use is voluntary. The application of OGTT as a diagnostic measurement of diabetes and gestational diabetes is widely used and in a consistent manner among the different regions of the world. Time specific (e.g., 2 hour) PPG is commonly used as a target not to exceed in individuals with diabetes and gestational diabetes. PPG is used by regulatory agencies for the substantiation of food labeling. There are differences, however, among regulatory agencies in the specific measure of PPG (i.e., PPG area-under-the-curve versus peak PPG). Maximum targets for 2-hour PPG for individuals with diabetes and gestational diabetes, ranging between 6 to 10 mmol/L, across countries suggests a potential consideration to harmonize PPG targets.
Conclusions:
There is general consistency in the use and/or target levels of glycaemic impact measures; however, there is a potential need to investigate harmonization strategies on certain aspects of glycaemic impact measures.